DNA damage bypass operates in the S and G2 phases of the cell cycle and exhibits differential mutagenicity

Translesion DNA synthesis (TLS) employs low-fidelity DNA polymerases to bypass replication-blocking lesions, and being associated with chromosomal replication was presumed to occur in the S phase of the cell cycle. Using immunostaining with anti-replication protein A antibodies, we show that in UV-i...

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Bibliographic Details
Published in:	Nucleic acids research Vol. 40; no. 1; pp. 170 - 180
Main Authors:	Diamant, Noam, Hendel, Ayal, Vered, Ilan, Carell, Thomas, Reißner, Thomas, de Wind, Niels, Geacinov, Nicholas, Livneh, Zvi
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 01.01.2012
Subjects:	Animals Cell Line, Tumor Cells, Cultured DNA - biosynthesis DNA Damage DNA-Binding Proteins - physiology DNA-Directed DNA Polymerase - physiology G2 Phase - genetics Genome Integrity, Repair and Humans Mice Mutagenesis Nuclear Proteins - physiology Nucleotidyltransferases - physiology Replication Protein A - analysis S Phase - genetics Ultraviolet Rays
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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