Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule

Activated leukocyte cell adhesion molecule (ALCAM/CD166/MEMD), a marker of various cancers and mesenchymal stem cells, is involved in melanoma metastasis. We have exploited a secreted NH(2)-terminal fragment, sALCAM, to test the hypothesis that ALCAM coordinates tissue growth and cell migration. Ove...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 68; H. 10; S. 3671
Hauptverfasser:	van Kilsdonk, Jeroen W J, Wilting, Roel H, Bergers, Mieke, van Muijen, Goos N P, Schalkwijk, Joost, van Kempen, Léon C L T, Swart, Guido W M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.05.2008
Schlagworte:	Activated-Leukocyte Cell Adhesion Molecule - chemistry Animals Basement Membrane - metabolism Cell Adhesion Cell Line, Tumor Gene Expression Regulation, Neoplastic Humans Leukocytes - cytology Melanoma - pathology Melanoma - therapy Mice Mice, Nude Neoplasm Invasiveness Neoplasm Metastasis Neural Cell Adhesion Molecule L1 - metabolism Protein Structure, Tertiary
ISSN:	1538-7445, 1538-7445
Online-Zugang:	Weitere Angaben
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