Pemphigus and hematologic malignancies: A population-based study of 11,859 patients
The association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established. To estimate the association between pemphigus and the common types of hematologic malignancies. A cross-sectional study was conducted comparing pemphigus patients with age-, sex- and ethn...
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| Vydané v: | Journal of the American Academy of Dermatology Ročník 78; číslo 6; s. 1084 - 1089.e1 |
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| Hlavní autori: | , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
Elsevier Inc
01.06.2018
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| ISSN: | 0190-9622, 1097-6787, 1097-6787 |
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| Abstract | The association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established.
To estimate the association between pemphigus and the common types of hematologic malignancies.
A cross-sectional study was conducted comparing pemphigus patients with age-, sex- and ethnicity-matched control subjects regarding the prevalence of 6 comorbid hematologic malignancies. The study was performed using the computerized database of Clalit Health Services ensuring the availability of 4.5 million patients.
The study included 1985 pemphigus patients and 9874 control subjects. The prevalence of chronic leukemia (0.9% vs 0.4%, odds ratio [OR] 2.1, 95% confidence interval [CI] 1.2-3.6), multiple myeloma (0.8% vs 0.4%, OR 2.2, 95% CI 1.2-3.9), and non-Hodgkin lymphoma (1.8% vs 1.2%, OR 1.5, 95% CI 1.0-2.2) was greater in patients with pemphigus than in controls. The association with chronic leukemia remained significant following the adjustment for immunosuppressive therapy (adjusted OR 2.0, 95% CI 1.1-3.7). No significant associations were observed between pemphigus and acute leukemia, Hodgkin lymphoma, myelodysplastic syndrome, and polycythemia vera.
Lack of immunopathologic validation of the diagnosis of pemphigus.
A significant association was observed between pemphigus and chronic leukemia, multiple myeloma, and non-Hodgkin lymphoma. Further research is warranted to establish this observation in other cohorts. |
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| AbstractList | The association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established.
To estimate the association between pemphigus and the common types of hematologic malignancies.
A cross-sectional study was conducted comparing pemphigus patients with age-, sex- and ethnicity-matched control subjects regarding the prevalence of 6 comorbid hematologic malignancies. The study was performed using the computerized database of Clalit Health Services ensuring the availability of 4.5 million patients.
The study included 1985 pemphigus patients and 9874 control subjects. The prevalence of chronic leukemia (0.9% vs 0.4%, odds ratio [OR] 2.1, 95% confidence interval [CI] 1.2-3.6), multiple myeloma (0.8% vs 0.4%, OR 2.2, 95% CI 1.2-3.9), and non-Hodgkin lymphoma (1.8% vs 1.2%, OR 1.5, 95% CI 1.0-2.2) was greater in patients with pemphigus than in controls. The association with chronic leukemia remained significant following the adjustment for immunosuppressive therapy (adjusted OR 2.0, 95% CI 1.1-3.7). No significant associations were observed between pemphigus and acute leukemia, Hodgkin lymphoma, myelodysplastic syndrome, and polycythemia vera.
Lack of immunopathologic validation of the diagnosis of pemphigus.
A significant association was observed between pemphigus and chronic leukemia, multiple myeloma, and non-Hodgkin lymphoma. Further research is warranted to establish this observation in other cohorts. The association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established.BACKGROUNDThe association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established.To estimate the association between pemphigus and the common types of hematologic malignancies.OBJECTIVETo estimate the association between pemphigus and the common types of hematologic malignancies.A cross-sectional study was conducted comparing pemphigus patients with age-, sex- and ethnicity-matched control subjects regarding the prevalence of 6 comorbid hematologic malignancies. The study was performed using the computerized database of Clalit Health Services ensuring the availability of 4.5 million patients.METHODSA cross-sectional study was conducted comparing pemphigus patients with age-, sex- and ethnicity-matched control subjects regarding the prevalence of 6 comorbid hematologic malignancies. The study was performed using the computerized database of Clalit Health Services ensuring the availability of 4.5 million patients.The study included 1985 pemphigus patients and 9874 control subjects. The prevalence of chronic leukemia (0.9% vs 0.4%, odds ratio [OR] 2.1, 95% confidence interval [CI] 1.2-3.6), multiple myeloma (0.8% vs 0.4%, OR 2.2, 95% CI 1.2-3.9), and non-Hodgkin lymphoma (1.8% vs 1.2%, OR 1.5, 95% CI 1.0-2.2) was greater in patients with pemphigus than in controls. The association with chronic leukemia remained significant following the adjustment for immunosuppressive therapy (adjusted OR 2.0, 95% CI 1.1-3.7). No significant associations were observed between pemphigus and acute leukemia, Hodgkin lymphoma, myelodysplastic syndrome, and polycythemia vera.RESULTSThe study included 1985 pemphigus patients and 9874 control subjects. The prevalence of chronic leukemia (0.9% vs 0.4%, odds ratio [OR] 2.1, 95% confidence interval [CI] 1.2-3.6), multiple myeloma (0.8% vs 0.4%, OR 2.2, 95% CI 1.2-3.9), and non-Hodgkin lymphoma (1.8% vs 1.2%, OR 1.5, 95% CI 1.0-2.2) was greater in patients with pemphigus than in controls. The association with chronic leukemia remained significant following the adjustment for immunosuppressive therapy (adjusted OR 2.0, 95% CI 1.1-3.7). No significant associations were observed between pemphigus and acute leukemia, Hodgkin lymphoma, myelodysplastic syndrome, and polycythemia vera.Lack of immunopathologic validation of the diagnosis of pemphigus.LIMITATIONSLack of immunopathologic validation of the diagnosis of pemphigus.A significant association was observed between pemphigus and chronic leukemia, multiple myeloma, and non-Hodgkin lymphoma. Further research is warranted to establish this observation in other cohorts.CONCLUSIONA significant association was observed between pemphigus and chronic leukemia, multiple myeloma, and non-Hodgkin lymphoma. Further research is warranted to establish this observation in other cohorts. |
| Author | Comaneshter, Doron Kridin, Khalaf Batat, Erez Zelber-Sagi, Shira Cohen, Arnon D. |
| Author_xml | – sequence: 1 givenname: Khalaf surname: Kridin fullname: Kridin, Khalaf email: dr_kridin@hotmail.com organization: Department of Dermatology, Rambam Health Care Campus, Haifa, Israel – sequence: 2 givenname: Shira surname: Zelber-Sagi fullname: Zelber-Sagi, Shira organization: School of Public Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel – sequence: 3 givenname: Doron surname: Comaneshter fullname: Comaneshter, Doron organization: Chief Physician's Office, Department of Quality Measurements and Research, Clalit Health Services, Tel Aviv, Israel – sequence: 4 givenname: Erez surname: Batat fullname: Batat, Erez organization: Chief Physician's Office, Department of Quality Measurements and Research, Clalit Health Services, Tel Aviv, Israel – sequence: 5 givenname: Arnon D. surname: Cohen fullname: Cohen, Arnon D. organization: Chief Physician's Office, Department of Quality Measurements and Research, Clalit Health Services, Tel Aviv, Israel |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29198780$$D View this record in MEDLINE/PubMed |
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| Keywords | hematologic malignancies leukemia multiple myeloma OR comorbidities pemphigus CI non-Hodgkin lymphoma |
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| Snippet | The association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established.
To estimate the association between pemphigus... The association of nonparaneoplastic pemphigus with comorbid hematologic malignancies has yet to be established.BACKGROUNDThe association of nonparaneoplastic... |
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| SubjectTerms | Age Distribution Aged Aged, 80 and over comorbidities Comorbidity Confidence Intervals Cross-Sectional Studies Female hematologic malignancies Hematologic Neoplasms - epidemiology Hematologic Neoplasms - pathology Humans Incidence Israel leukemia Lymphoma, Non-Hodgkin - epidemiology Lymphoma, Non-Hodgkin - pathology Male Middle Aged multiple myeloma Multiple Myeloma - epidemiology Multiple Myeloma - pathology non-Hodgkin lymphoma Odds Ratio pemphigus Pemphigus - epidemiology Pemphigus - pathology Prognosis Severity of Illness Index Sex Distribution Survival Analysis |
| Title | Pemphigus and hematologic malignancies: A population-based study of 11,859 patients |
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