Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention

This multicenter pragmatic investigation assessed outcomes following clinical implementation of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention (PCI). CYP2C19 loss-of-function alleles impair clopidogrel effectiveness after PCI. After clinical genotyping, each in...

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Bibliographic Details

Published in:	JACC. Cardiovascular interventions Vol. 11; no. 2; p. 181
Main Authors:	Cavallari, Larisa H, Lee, Craig R, Beitelshees, Amber L, Cooper-DeHoff, Rhonda M, Duarte, Julio D, Voora, Deepak, Kimmel, Stephen E, McDonough, Caitrin W, Gong, Yan, Dave, Chintan V, Pratt, Victoria M, Alestock, Tameka D, Anderson, R David, Alsip, Jorge, Ardati, Amer K, Brott, Brigitta C, Brown, Lawrence, Chumnumwat, Supatat, Clare-Salzler, Michael J, Coons, James C, Denny, Joshua C, Dillon, Chrisly, Elsey, Amanda R, Hamadeh, Issam S, Harada, Shuko, Hillegass, William B, Hines, Lindsay, Horenstein, Richard B, Howell, Lucius A, Jeng, Linda J B, Kelemen, Mark D, Lee, Yee Ming, Magvanjav, Oyunbileg, Montasser, May, Nelson, David R, Nutescu, Edith A, Nwaba, Devon C, Pakyz, Ruth E, Palmer, Kathleen, Peterson, Josh F, Pollin, Toni I, Quinn, Alison H, Robinson, Shawn W, Schub, Jamie, Skaar, Todd C, Smith, D Max, Sriramoju, Vindhya B, Starostik, Petr, Stys, Tomasz P, Stevenson, James M, Varunok, Nicholas, Vesely, Mark R, Wake, Dyson T, Weck, Karen E, Weitzel, Kristin W, Wilke, Russell A, Willig, James, Zhao, Richard Y, Kreutz, Rolf P, Stouffer, George A, Empey, Philip E, Limdi, Nita A, Shuldiner, Alan R, Winterstein, Almut G, Johnson, Julie A
Format:	Journal Article
Language:	English
Published:	United States 22.01.2018
Subjects:	cardiovascular events clopidogrel percutaneous coronary intervention pharmacogenomics antiplatelet therapy CYP2C19
ISSN:	1876-7605, 1876-7605
Online Access:	Get more information
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