Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention

This multicenter pragmatic investigation assessed outcomes following clinical implementation of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention (PCI). CYP2C19 loss-of-function alleles impair clopidogrel effectiveness after PCI. After clinical genotyping, each in...

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Vydáno v:	JACC. Cardiovascular interventions Ročník 11; číslo 2; s. 181
Hlavní autoři:	Cavallari, Larisa H, Lee, Craig R, Beitelshees, Amber L, Cooper-DeHoff, Rhonda M, Duarte, Julio D, Voora, Deepak, Kimmel, Stephen E, McDonough, Caitrin W, Gong, Yan, Dave, Chintan V, Pratt, Victoria M, Alestock, Tameka D, Anderson, R David, Alsip, Jorge, Ardati, Amer K, Brott, Brigitta C, Brown, Lawrence, Chumnumwat, Supatat, Clare-Salzler, Michael J, Coons, James C, Denny, Joshua C, Dillon, Chrisly, Elsey, Amanda R, Hamadeh, Issam S, Harada, Shuko, Hillegass, William B, Hines, Lindsay, Horenstein, Richard B, Howell, Lucius A, Jeng, Linda J B, Kelemen, Mark D, Lee, Yee Ming, Magvanjav, Oyunbileg, Montasser, May, Nelson, David R, Nutescu, Edith A, Nwaba, Devon C, Pakyz, Ruth E, Palmer, Kathleen, Peterson, Josh F, Pollin, Toni I, Quinn, Alison H, Robinson, Shawn W, Schub, Jamie, Skaar, Todd C, Smith, D Max, Sriramoju, Vindhya B, Starostik, Petr, Stys, Tomasz P, Stevenson, James M, Varunok, Nicholas, Vesely, Mark R, Wake, Dyson T, Weck, Karen E, Weitzel, Kristin W, Wilke, Russell A, Willig, James, Zhao, Richard Y, Kreutz, Rolf P, Stouffer, George A, Empey, Philip E, Limdi, Nita A, Shuldiner, Alan R, Winterstein, Almut G, Johnson, Julie A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 22.01.2018
Témata:	cardiovascular events clopidogrel percutaneous coronary intervention pharmacogenomics antiplatelet therapy CYP2C19
ISSN:	1876-7605, 1876-7605
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