Multisite Investigation of Outcomes With Implementation of CYP2C19 Genotype-Guided Antiplatelet Therapy After Percutaneous Coronary Intervention

This multicenter pragmatic investigation assessed outcomes following clinical implementation of CYP2C19 genotype-guided antiplatelet therapy after percutaneous coronary intervention (PCI). CYP2C19 loss-of-function alleles impair clopidogrel effectiveness after PCI. After clinical genotyping, each in...

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Veröffentlicht in:	JACC. Cardiovascular interventions Jg. 11; H. 2; S. 181
Hauptverfasser:	Cavallari, Larisa H, Lee, Craig R, Beitelshees, Amber L, Cooper-DeHoff, Rhonda M, Duarte, Julio D, Voora, Deepak, Kimmel, Stephen E, McDonough, Caitrin W, Gong, Yan, Dave, Chintan V, Pratt, Victoria M, Alestock, Tameka D, Anderson, R David, Alsip, Jorge, Ardati, Amer K, Brott, Brigitta C, Brown, Lawrence, Chumnumwat, Supatat, Clare-Salzler, Michael J, Coons, James C, Denny, Joshua C, Dillon, Chrisly, Elsey, Amanda R, Hamadeh, Issam S, Harada, Shuko, Hillegass, William B, Hines, Lindsay, Horenstein, Richard B, Howell, Lucius A, Jeng, Linda J B, Kelemen, Mark D, Lee, Yee Ming, Magvanjav, Oyunbileg, Montasser, May, Nelson, David R, Nutescu, Edith A, Nwaba, Devon C, Pakyz, Ruth E, Palmer, Kathleen, Peterson, Josh F, Pollin, Toni I, Quinn, Alison H, Robinson, Shawn W, Schub, Jamie, Skaar, Todd C, Smith, D Max, Sriramoju, Vindhya B, Starostik, Petr, Stys, Tomasz P, Stevenson, James M, Varunok, Nicholas, Vesely, Mark R, Wake, Dyson T, Weck, Karen E, Weitzel, Kristin W, Wilke, Russell A, Willig, James, Zhao, Richard Y, Kreutz, Rolf P, Stouffer, George A, Empey, Philip E, Limdi, Nita A, Shuldiner, Alan R, Winterstein, Almut G, Johnson, Julie A
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 22.01.2018
Schlagworte:	cardiovascular events clopidogrel percutaneous coronary intervention pharmacogenomics antiplatelet therapy CYP2C19
ISSN:	1876-7605, 1876-7605
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