Dedifferentiated melanomas: Morpho-phenotypic profile, genetic reprogramming and clinical implications

•Dedifferentiated melanomas pose diagnostic interpretative challenges.•Dedifferentiation underlies the phenotypic and genetic plasticity of melanoma.•Melanoma cells can shift through different transcriptional programs of differentiation.•Dedifferentiation is a mechanism of resistance to immunotherap...

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Bibliographic Details
Published in:	Cancer treatment reviews Vol. 88; p. 102060
Main Authors:	Massi, Daniela, Mihic-Probst, Daniela, Schadendorf, Dirk, Dummer, Reinhard, Mandalà, Mario
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 01.08.2020
Subjects:	Animals Cell Dedifferentiation - physiology Cellular Reprogramming - physiology Dedifferentiated Epigenesis, Genetic Humans Immunotherapy MAPK inhibitors Melanoma Melanoma - genetics Melanoma - pathology Melanoma - therapy Melanoma, Cutaneous Malignant Phenotype Resistance Skin Neoplasms - genetics Skin Neoplasms - pathology Skin Neoplasms - therapy Resistance MAPK inhibitors Phenotype Dedifferentiated Immunotherapy Melanoma
ISSN:	0305-7372, 1532-1967, 1532-1967
Online Access:	Get full text
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