Decreasing trends of drug resistance and increase of non-B subtypes amongst subjects recently diagnosed as HIV-infected over the period 2004–2012 in the Veneto Region, Italy
The present study was designed to prospectively monitor transmitted drug resistance mutations (TDRMs) in the Veneto Region, Italy. Genotypic resistance testing was conducted on the plasma of 1882 patients consecutively enrolled at the time of diagnosis of human immunodeficiency virus (HIV) infection...
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| Veröffentlicht in: | Journal of Global Antimicrobial Resistance Jg. 1; H. 4; S. 201 - 206 |
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| Sprache: | Englisch |
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01.12.2013
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| ISSN: | 2213-7165, 2213-7173, 2213-7165, 2213-7173 |
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| Abstract | The present study was designed to prospectively monitor transmitted drug resistance mutations (TDRMs) in the Veneto Region, Italy. Genotypic resistance testing was conducted on the plasma of 1882 patients consecutively enrolled at the time of diagnosis of human immunodeficiency virus (HIV) infection from 2004 to 2012. TDRMs were defined according to the Stanford HIV database algorithm. In total, 214 (16.1%) B subtype-infected and 58 (10.5%) non-B subtype-infected individuals were identified as having a primary or recent HIV-1 infection. In subtype B-infected subjects in 2004–2006, the prevalence of TDRMs was 20.0% in chronic infections and 25.5% in recent infections; in 2007–2009 the rates were 11.5% and 5.3%, respectively; and in 2010–2012 they were 11.3% and 15.2%, respectively. In non-B subtype-infected subjects in 2004–2006, the prevalence of TDRMs was 18.0% in chronic infections and 16.5% in recent infections; in 2007–2009 the rates were 5.7% and 0%, respectively; and in 2010–2012 they were 6.2% and 8.7%, respectively. Protease inhibitor resistance and combined resistance to two or three classes of drugs declined during the three study periods. The observed decrease in TDRMs and a simplification of the resistance patterns may reflect a change over time in the characteristics of the infecting subjects who are often unaware of their infection and transmit a wild-type strain. |
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| AbstractList | The present study was designed to prospectively monitor transmitted drug resistance mutations (TDRMs) in the Veneto Region, Italy. Genotypic resistance testing was conducted on the plasma of 1882 patients consecutively enrolled at the time of diagnosis of human immunodeficiency virus (HIV) infection from 2004 to 2012. TDRMs were defined according to the Stanford HIV database algorithm. In total, 214 (16.1%) B subtype-infected and 58 (10.5%) non-B subtype-infected individuals were identified as having a primary or recent HIV-1 infection. In subtype B-infected subjects in 2004–2006, the prevalence of TDRMs was 20.0% in chronic infections and 25.5% in recent infections; in 2007–2009 the rates were 11.5% and 5.3%, respectively; and in 2010–2012 they were 11.3% and 15.2%, respectively. In non-B subtype-infected subjects in 2004–2006, the prevalence of TDRMs was 18.0% in chronic infections and 16.5% in recent infections; in 2007–2009 the rates were 5.7% and 0%, respectively; and in 2010–2012 they were 6.2% and 8.7%, respectively. Protease inhibitor resistance and combined resistance to two or three classes of drugs declined during the three study periods. The observed decrease in TDRMs and a simplification of the resistance patterns may reflect a change over time in the characteristics of the infecting subjects who are often unaware of their infection and transmit a wild-type strain. The present study was designed to prospectively monitor transmitted drug resistance mutations (TDRMs) in the Veneto Region, Italy. Genotypic resistance testing was conducted on the plasma of 1882 patients consecutively enrolled at the time of diagnosis of human immunodeficiency virus (HIV) infection from 2004 to 2012. TDRMs were defined according to the Stanford HIV database algorithm. In total, 214 (16.1%) B subtype-infected and 58 (10.5%) non-B subtype-infected individuals were identified as having a primary or recent HIV-1 infection. In subtype B-infected subjects in 2004-2006, the prevalence of TDRMs was 20.0% in chronic infections and 25.5% in recent infections; in 2007-2009 the rates were 11.5% and 5.3%, respectively; and in 2010-2012 they were 11.3% and 15.2%, respectively. In non-B subtype-infected subjects in 2004-2006, the prevalence of TDRMs was 18.0% in chronic infections and 16.5% in recent infections; in 2007-2009 the rates were 5.7% and 0%, respectively; and in 2010-2012 they were 6.2% and 8.7%, respectively. Protease inhibitor resistance and combined resistance to two or three classes of drugs declined during the three study periods. The observed decrease in TDRMs and a simplification of the resistance patterns may reflect a change over time in the characteristics of the infecting subjects who are often unaware of their infection and transmit a wild-type strain.The present study was designed to prospectively monitor transmitted drug resistance mutations (TDRMs) in the Veneto Region, Italy. Genotypic resistance testing was conducted on the plasma of 1882 patients consecutively enrolled at the time of diagnosis of human immunodeficiency virus (HIV) infection from 2004 to 2012. TDRMs were defined according to the Stanford HIV database algorithm. In total, 214 (16.1%) B subtype-infected and 58 (10.5%) non-B subtype-infected individuals were identified as having a primary or recent HIV-1 infection. In subtype B-infected subjects in 2004-2006, the prevalence of TDRMs was 20.0% in chronic infections and 25.5% in recent infections; in 2007-2009 the rates were 11.5% and 5.3%, respectively; and in 2010-2012 they were 11.3% and 15.2%, respectively. In non-B subtype-infected subjects in 2004-2006, the prevalence of TDRMs was 18.0% in chronic infections and 16.5% in recent infections; in 2007-2009 the rates were 5.7% and 0%, respectively; and in 2010-2012 they were 6.2% and 8.7%, respectively. Protease inhibitor resistance and combined resistance to two or three classes of drugs declined during the three study periods. The observed decrease in TDRMs and a simplification of the resistance patterns may reflect a change over time in the characteristics of the infecting subjects who are often unaware of their infection and transmit a wild-type strain. |
| Author | Andreis, Samantha Cruciani, Mario Francavilla, Ermenegildo Panese, Sandro Rossi, Maria Cristina Dal Bello, Federico Basso, Monica Manfrin, Vinicio Mengoli, Carlo Ferretto, Roberto Boldrin, Caterina Scaggiante, Renzo Parisi, Saverio Giuseppe Palù, Giorgio Andreoni, Massimo |
| Author_xml | – sequence: 1 givenname: Saverio Giuseppe surname: Parisi fullname: Parisi, Saverio Giuseppe email: saverio.parisi@unipd.it, saverio.parisi@sanita.padova.it organization: Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35100 Padua, Italy – sequence: 2 givenname: Samantha surname: Andreis fullname: Andreis, Samantha organization: Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35100 Padua, Italy – sequence: 3 givenname: Renzo surname: Scaggiante fullname: Scaggiante, Renzo organization: Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35100 Padua, Italy – sequence: 4 givenname: Mario surname: Cruciani fullname: Cruciani, Mario organization: Centre of Community & Medicine and HIV Outpatient Clinic, Verona, Italy – sequence: 5 givenname: Roberto surname: Ferretto fullname: Ferretto, Roberto organization: Infectious Diseases, Schio Hospital, Schio, Italy – sequence: 6 givenname: Vinicio surname: Manfrin fullname: Manfrin, Vinicio organization: Infectious Diseases, Vicenza Hospital, Vicenza, Italy – sequence: 7 givenname: Sandro surname: Panese fullname: Panese, Sandro organization: Infectious Diseases, Venezia Hospital, Venice, Italy – sequence: 8 givenname: Maria Cristina surname: Rossi fullname: Rossi, Maria Cristina organization: Infectious Diseases, Treviso Hospital, Treviso, Italy – sequence: 9 givenname: Ermenegildo surname: Francavilla fullname: Francavilla, Ermenegildo organization: Infectious Diseases, Belluno Hospital, Belluno, Italy – sequence: 10 givenname: Caterina surname: Boldrin fullname: Boldrin, Caterina organization: Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35100 Padua, Italy – sequence: 11 givenname: Federico surname: Dal Bello fullname: Dal Bello, Federico organization: Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35100 Padua, Italy – sequence: 12 givenname: Monica surname: Basso fullname: Basso, Monica organization: Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35100 Padua, Italy – sequence: 13 givenname: Carlo surname: Mengoli fullname: Mengoli, Carlo organization: Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35100 Padua, Italy – sequence: 14 givenname: Massimo surname: Andreoni fullname: Andreoni, Massimo organization: Infectious Diseases Department, Tor Vergata University, Rome, Italy – sequence: 15 givenname: Giorgio surname: Palù fullname: Palù, Giorgio organization: Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35100 Padua, Italy |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27873613$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_v17060832 crossref_primary_10_1016_j_jgar_2015_07_006 crossref_primary_10_1016_j_jgar_2017_05_011 crossref_primary_10_1016_j_jgar_2019_08_024 crossref_primary_10_3390_v15081727 crossref_primary_10_1186_s12889_019_7004_x crossref_primary_10_3390_v16091393 |
| Cites_doi | 10.1097/01.aids.0000252059.85236.af 10.1186/1471-2334-9-111 10.1002/jmv.21139 10.1097/QAD.0b013e32835d9f6d 10.1097/QAD.0b013e32833677ac 10.1001/jama.2012.7961 10.1093/jac/dkq380 10.1111/j.1469-0691.2012.03847.x 10.1093/jac/dkp246 10.1097/QAD.0b013e328326ca77 10.1097/QAD.0b013e3282f5e062 10.1128/JCM.00056-07 10.1056/NEJM199304223281605 10.1086/432916 10.1097/QAD.0b013e3283388742 10.1111/1469-0691.12011 10.1093/jac/dks470 10.1128/AAC.01192-10 10.1086/644505 10.1097/01.aids.0000232246.36039.f0 |
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| Copyright | 2013 International Society for Chemotherapy of Infection and Cancer Copyright © 2013 International Society for Chemotherapy of Infection and Cancer. Published by Elsevier Ltd. All rights reserved. |
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| Keywords | Resistance Chronic infection HIV subtype Primary infection Epidemiology |
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| References | Chaix, Descamps, Wirden, Bocket, Delaugerre, Tamalet (bib0040) 2009; 23 Vercauteren, Wensing, van de Vijver, Albert, Balotta, Hamouda (bib0030) 2009; 200 Alteri, Svicher, Gori, D’Arrigo, Ciccozzi, Ceccherini-Silberstein (bib0060) 2009; 9 Vercauteren, Theys, Carvalho, Valadas, Duque, Teófilo (bib0075) 2013; 68 Lapadula, Izzo, Gargiulo, Paraninfo, Castelnuovo, Quiros-Roldan (bib0055) 2008; 80 Erice, Mayers, Strike, Sannerud, McCutchan, Henry (bib0005) 1993; 328 Truong, Grant, McFarland, Kellogg, Kent, Louie (bib0015) 2006; 20 Parisi, Mazzi, Boldrin, Dal Bello, Franchin, Andreoni (bib0080) 2006; 20 Monge, Guillot, Alvarez, Peña, Viciana, García-Bujalance (bib0085) 2012; 18 Wheeler, Ziebell, Zabina, Pieniazek, Prejean, Bodnar (bib0010) 2010; 24 Descamps, Chaix, Montes, Pakianather, Charpentier, Storto (bib0035) 2010; 65 Asahchop, Oliveira, Wainberg, Brenner, Moisi, Toni Td (bib0090) 2011; 55 Parisi, Boldrin, Cruciani, Nicolini, Cerbaro, Manfrin (bib0065) 2007; 45 Colafigli, Torti, Trecarichi, Albini, Rosi, Micheli (bib0050) 2012; 18 Thompson, Aberg, Hoy, Telenti, Benson, Cahn (bib0070) 2012; 308 Asahchop, Wainberg, Oliveira, Xu, Brenner, Moisi (bib0095) 2013; 27 Vingerhoets, Tambuyzer, Azijn, Hoogstoel, Nijs, Peeters (bib0100) 2010; 24 Wensing, van de Vijver, Angarano, Asjö, Balotta, Boeri (bib0020) 2005; 192 SPREAD Programme (bib0025) 2008; 22 Bracciale, Colafigli, Zazzi, Corsi, Meraviglia, Micheli (bib0045) 2009; 64 SPREAD Programme (10.1016/j.jgar.2013.05.008_bib0025) 2008; 22 Vercauteren (10.1016/j.jgar.2013.05.008_bib0075) 2013; 68 Lapadula (10.1016/j.jgar.2013.05.008_bib0055) 2008; 80 Parisi (10.1016/j.jgar.2013.05.008_bib0065) 2007; 45 Asahchop (10.1016/j.jgar.2013.05.008_bib0095) 2013; 27 Colafigli (10.1016/j.jgar.2013.05.008_bib0050) 2012; 18 Bracciale (10.1016/j.jgar.2013.05.008_bib0045) 2009; 64 Wheeler (10.1016/j.jgar.2013.05.008_bib0010) 2010; 24 Descamps (10.1016/j.jgar.2013.05.008_bib0035) 2010; 65 Erice (10.1016/j.jgar.2013.05.008_bib0005) 1993; 328 Alteri (10.1016/j.jgar.2013.05.008_bib0060) 2009; 9 Wensing (10.1016/j.jgar.2013.05.008_bib0020) 2005; 192 Chaix (10.1016/j.jgar.2013.05.008_bib0040) 2009; 23 Asahchop (10.1016/j.jgar.2013.05.008_bib0090) 2011; 55 Vingerhoets (10.1016/j.jgar.2013.05.008_bib0100) 2010; 24 Parisi (10.1016/j.jgar.2013.05.008_bib0080) 2006; 20 Truong (10.1016/j.jgar.2013.05.008_bib0015) 2006; 20 Vercauteren (10.1016/j.jgar.2013.05.008_bib0030) 2009; 200 Thompson (10.1016/j.jgar.2013.05.008_bib0070) 2012; 308 Monge (10.1016/j.jgar.2013.05.008_bib0085) 2012; 18 |
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| Title | Decreasing trends of drug resistance and increase of non-B subtypes amongst subjects recently diagnosed as HIV-infected over the period 2004–2012 in the Veneto Region, Italy |
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