Induction treatment with FOLFIRINOX or oxaliplatin-based doublet followed by long-course chemoradiotherapy and surgery in locally advanced rectal cancer. A systematic review and pooled analysis from phase II and III trials

•Induction chemotherapy with FOLFIRINOX followed by long-course CTRT versus CTRT alone improved survival outcomes.•The lack of head-to-head comparisons among triplet and doublet induction in LARC represents an unmet need.•We conducted a systematic review and IPSD pooled analysis including phase II-I...

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