Evaluation of concordance between the microorganisms detected in the nasopharynx and middle ear of children with otitis media

Studies of microorganisms involved in otitis media in children often use a nasopharyngeal sample as a proxy for the middle ear fluid to test for bacteria and viruses. The question is whether such studies provide an accurate estimate of the prevalence of microorganisms involved in otitis media. We pe...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:The Pediatric infectious disease journal Ročník 32; číslo 5; s. 549
Hlavní autoři: van Dongen, Thijs M A, van der Heijden, Geert J M G, van Zon, Alice, Bogaert, Debby, Sanders, Elisabeth A M, Schilder, Anne G M
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.05.2013
Témata:
Adolescent
Bacteria - classification
Bacteria - genetics
Bacteria - isolation & purification
Child
Child, Preschool
Ear, Middle - microbiology
Ear, Middle - virology
Humans
Nasopharynx - microbiology
Nasopharynx - virology
Otitis Media - microbiology
Otitis Media - virology
Polymerase Chain Reaction
Predictive Value of Tests
Viruses - classification
Viruses - genetics
Viruses - isolation & purification
ISSN:1532-0987, 1532-0987
On-line přístup:Zjistit podrobnosti o přístupu
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Studies of microorganisms involved in otitis media in children often use a nasopharyngeal sample as a proxy for the middle ear fluid to test for bacteria and viruses. The question is whether such studies provide an accurate estimate of the prevalence of microorganisms involved in otitis media. We performed a systematic review of the literature reporting on the concordance between test results of nasopharyngeal and middle ear fluid samples for the most prevalent microorganisms in children with otitis media. Our findings show that the concordances vary from 68% to 97% per microorganism. For the most prevalent microbes, positive predictive values are around 50%. Most negative predictive values are moderate to high, with a range from 68% up to 97%. These results indicate that test results from nasopharyngeal samples do not always provide an accurate proxy for those of the middle ear fluid. It is important to interpret and use results of such studies carefully.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ObjectType-Undefined-4
ISSN:1532-0987
1532-0987
DOI:10.1097/INF.0b013e318280ab45