A systematic review of cranioplasty material toxicity in human subjects

Local and systemic toxic reactions to implanted materials can result in morbidities. However, little is reported about cranioplasty implants. Therefore, we performed a systematic review on the toxicity of different materials used for cranioplasty implants. A systematic search was conducted by browsi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of cranio-maxillo-facial surgery Jg. 49; H. 1; S. 34 - 46
Hauptverfasser: Las, David Emmanuel, Verwilghen, Denis, Mommaerts, Maurice Yves
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Scotland Elsevier Ltd 01.01.2021
Schlagworte:
Biocompatible materials
Cranioplasty
Dental Implants
Humans
Neurotoxicity
Postoperative Complications - etiology
Prostheses and Implants - adverse effects
Reconstructive Surgical Procedures
Research Subjects
Retrospective Studies
Skull - surgery
Titanium - toxicity
Toxicity
Neurotoxicity
Cranioplasty
Toxicity
Biocompatible materials
ISSN:1010-5182, 1878-4119, 1878-4119
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Local and systemic toxic reactions to implanted materials can result in morbidities. However, little is reported about cranioplasty implants. Therefore, we performed a systematic review on the toxicity of different materials used for cranioplasty implants. A systematic search was conducted by browsing the Pubmed, Embase, and Cochrane Library databases. All human studies that identified toxic (aseptic) reactions to any types of material used as cranioplasty implants or onplants, published up to January 1, 2019, were included in the review. Nineteen studies were identified. Collectively, 36 patients endured some type of toxic reaction to an implanted material. Eleven studies presented several types of toxicity for PMMA cranioplasties in several tissue types. One article highlighted the risk of neurotoxicity for PMMA cranioplasty. Three articles presented toxic reactions to calcium phosphate and titanium implants. Three additional articles presented toxic reactions to PEEK, polypropylene-polyester, and polyethylene. All materials currently used for cranioplasty showed occasional toxicity and morbidities. Therefore, none can be considered completely biologically inert. We found that aseptic inflammatory reactions have been underreported in the literature due to a high incidence of infections with questionable evidence.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ISSN:1010-5182
1878-4119
1878-4119
DOI:10.1016/j.jcms.2020.10.002