GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

Oxygen is necessary for aerobic metabolism but can cause the harmful oxidation of lipids and other macromolecules. Oxidation of cholesterol and phospholipids containing polyunsaturated fatty acyl chains can lead to lipid peroxidation, membrane damage, and cell death. Lipid hydroperoxides are key int...

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Bibliographic Details

Published in:	Proteomics (Weinheim) Vol. 19; no. 18; pp. e1800311 - n/a
Main Authors:	Forcina, Giovanni C., Dixon, Scott J.
Format:	Journal Article
Language:	English
Published:	Germany 01.09.2019
Subjects:	cell death ferroptosis glutathione GPX4 iron lipids reactive oxygen species lipids ferroptosis GPX4 cell death glutathione reactive oxygen species iron
ISSN:	1615-9853, 1615-9861, 1615-9861
Online Access:	Get full text
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