Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration
A magnetic resonance imaging study of human cadaver spines. To investigate associations between cartilage endplate (CEP) thickness and disc degeneration. Damage to the CEP is associated with spinal injury and back pain. However, CEP morphology and its association with disc degeneration have not been...
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| Published in: | Spine (Philadelphia, Pa. 1976) Vol. 43; no. 10; p. E592 |
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| Main Authors: | , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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15.05.2018
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| ISSN: | 1528-1159, 1528-1159 |
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| Abstract | A magnetic resonance imaging study of human cadaver spines.
To investigate associations between cartilage endplate (CEP) thickness and disc degeneration.
Damage to the CEP is associated with spinal injury and back pain. However, CEP morphology and its association with disc degeneration have not been well characterized.
Ten lumbar motion segments with varying degrees of disc degeneration were harvested from six cadaveric spines and scanned with magnetic resonance imaging in the sagittal plane using a T2-weighted two-dimensional (2D) sequence, a three-dimensional (3D) ultrashort echo-time (UTE) imaging sequence, and a 3D T1ρ mapping sequence. CEP thicknesses were calculated from 3D UTE image data using a custom, automated algorithm, and these values were validated against histology measurements. Pfirrmann grades and T1ρ values in the disc were assessed and correlated with CEP thickness.
The mean CEP thickness calculated from UTE images was 0.74 ± 0.04 mm. Statistical comparisons between histology and UTE-derived measurements of CEP thickness showed significant agreement, with the mean difference not significantly different from zero (P = 0.32). Within-disc variation of T1ρ (standard deviation) was significantly lower for Pfirrmann grade 4 than Pfirrmann grade 3 (P < 0.05). Within-disc variation of T1ρ and adjacent CEP thickness heterogeneity (coefficient of variation) had a significant negative correlation (r = -0.65, P = 0.04). The standard deviation of T1ρand the mean CEP thickness showed a moderate positive correlation (r = 0.40, P = 0.26).
This study demonstrates that quantitative measurements of CEP thickness measured from UTE magnetic resonance imaging are associated with disc degeneration. Our results suggest that variability in CEP thickness and T1ρ, rather than their mean values, may serve as valuable diagnostic markers for disc degeneration.
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| AbstractList | A magnetic resonance imaging study of human cadaver spines.STUDY DESIGNA magnetic resonance imaging study of human cadaver spines.To investigate associations between cartilage endplate (CEP) thickness and disc degeneration.OBJECTIVETo investigate associations between cartilage endplate (CEP) thickness and disc degeneration.Damage to the CEP is associated with spinal injury and back pain. However, CEP morphology and its association with disc degeneration have not been well characterized.SUMMARY OF BACKGROUND DATADamage to the CEP is associated with spinal injury and back pain. However, CEP morphology and its association with disc degeneration have not been well characterized.Ten lumbar motion segments with varying degrees of disc degeneration were harvested from six cadaveric spines and scanned with magnetic resonance imaging in the sagittal plane using a T2-weighted two-dimensional (2D) sequence, a three-dimensional (3D) ultrashort echo-time (UTE) imaging sequence, and a 3D T1ρ mapping sequence. CEP thicknesses were calculated from 3D UTE image data using a custom, automated algorithm, and these values were validated against histology measurements. Pfirrmann grades and T1ρ values in the disc were assessed and correlated with CEP thickness.METHODSTen lumbar motion segments with varying degrees of disc degeneration were harvested from six cadaveric spines and scanned with magnetic resonance imaging in the sagittal plane using a T2-weighted two-dimensional (2D) sequence, a three-dimensional (3D) ultrashort echo-time (UTE) imaging sequence, and a 3D T1ρ mapping sequence. CEP thicknesses were calculated from 3D UTE image data using a custom, automated algorithm, and these values were validated against histology measurements. Pfirrmann grades and T1ρ values in the disc were assessed and correlated with CEP thickness.The mean CEP thickness calculated from UTE images was 0.74 ± 0.04 mm. Statistical comparisons between histology and UTE-derived measurements of CEP thickness showed significant agreement, with the mean difference not significantly different from zero (P = 0.32). Within-disc variation of T1ρ (standard deviation) was significantly lower for Pfirrmann grade 4 than Pfirrmann grade 3 (P < 0.05). Within-disc variation of T1ρ and adjacent CEP thickness heterogeneity (coefficient of variation) had a significant negative correlation (r = -0.65, P = 0.04). The standard deviation of T1ρand the mean CEP thickness showed a moderate positive correlation (r = 0.40, P = 0.26).RESULTSThe mean CEP thickness calculated from UTE images was 0.74 ± 0.04 mm. Statistical comparisons between histology and UTE-derived measurements of CEP thickness showed significant agreement, with the mean difference not significantly different from zero (P = 0.32). Within-disc variation of T1ρ (standard deviation) was significantly lower for Pfirrmann grade 4 than Pfirrmann grade 3 (P < 0.05). Within-disc variation of T1ρ and adjacent CEP thickness heterogeneity (coefficient of variation) had a significant negative correlation (r = -0.65, P = 0.04). The standard deviation of T1ρand the mean CEP thickness showed a moderate positive correlation (r = 0.40, P = 0.26).This study demonstrates that quantitative measurements of CEP thickness measured from UTE magnetic resonance imaging are associated with disc degeneration. Our results suggest that variability in CEP thickness and T1ρ, rather than their mean values, may serve as valuable diagnostic markers for disc degeneration.CONCLUSIONThis study demonstrates that quantitative measurements of CEP thickness measured from UTE magnetic resonance imaging are associated with disc degeneration. Our results suggest that variability in CEP thickness and T1ρ, rather than their mean values, may serve as valuable diagnostic markers for disc degeneration.N/A.LEVEL OF EVIDENCEN/A. A magnetic resonance imaging study of human cadaver spines. To investigate associations between cartilage endplate (CEP) thickness and disc degeneration. Damage to the CEP is associated with spinal injury and back pain. However, CEP morphology and its association with disc degeneration have not been well characterized. Ten lumbar motion segments with varying degrees of disc degeneration were harvested from six cadaveric spines and scanned with magnetic resonance imaging in the sagittal plane using a T2-weighted two-dimensional (2D) sequence, a three-dimensional (3D) ultrashort echo-time (UTE) imaging sequence, and a 3D T1ρ mapping sequence. CEP thicknesses were calculated from 3D UTE image data using a custom, automated algorithm, and these values were validated against histology measurements. Pfirrmann grades and T1ρ values in the disc were assessed and correlated with CEP thickness. The mean CEP thickness calculated from UTE images was 0.74 ± 0.04 mm. Statistical comparisons between histology and UTE-derived measurements of CEP thickness showed significant agreement, with the mean difference not significantly different from zero (P = 0.32). Within-disc variation of T1ρ (standard deviation) was significantly lower for Pfirrmann grade 4 than Pfirrmann grade 3 (P < 0.05). Within-disc variation of T1ρ and adjacent CEP thickness heterogeneity (coefficient of variation) had a significant negative correlation (r = -0.65, P = 0.04). The standard deviation of T1ρand the mean CEP thickness showed a moderate positive correlation (r = 0.40, P = 0.26). This study demonstrates that quantitative measurements of CEP thickness measured from UTE magnetic resonance imaging are associated with disc degeneration. Our results suggest that variability in CEP thickness and T1ρ, rather than their mean values, may serve as valuable diagnostic markers for disc degeneration. N/A. |
| Author | Lotz, Jeffrey C Fields, Aaron J Berg-Johansen, Britta Krug, Roland Larson, Peder Ez Gunduz-Demir, Cigdem Liebenberg, Ellen C Kazakia, Galateia J Han, Misung Lim, Brandon J |
| Author_xml | – sequence: 1 givenname: Britta surname: Berg-Johansen fullname: Berg-Johansen, Britta organization: Department of Bioengineering, UC Berkeley/UCSF Joint Program in Bioengineering, Berkeley, CA – sequence: 2 givenname: Misung surname: Han fullname: Han, Misung organization: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA – sequence: 3 givenname: Aaron J surname: Fields fullname: Fields, Aaron J organization: Department of Orthopaedic Surgery, University of California, San Francisco, CA – sequence: 4 givenname: Ellen C surname: Liebenberg fullname: Liebenberg, Ellen C organization: Department of Orthopaedic Surgery, University of California, San Francisco, CA – sequence: 5 givenname: Brandon J surname: Lim fullname: Lim, Brandon J organization: Department of Orthopaedic Surgery, University of California, San Francisco, CA – sequence: 6 givenname: Peder Ez surname: Larson fullname: Larson, Peder Ez organization: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA – sequence: 7 givenname: Cigdem surname: Gunduz-Demir fullname: Gunduz-Demir, Cigdem organization: Neuroscience Graduate Program, Bilkent University, Ankara, Turkey – sequence: 8 givenname: Galateia J surname: Kazakia fullname: Kazakia, Galateia J organization: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA – sequence: 9 givenname: Roland surname: Krug fullname: Krug, Roland organization: Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA – sequence: 10 givenname: Jeffrey C surname: Lotz fullname: Lotz, Jeffrey C organization: Department of Bioengineering, UC Berkeley/UCSF Joint Program in Bioengineering, Berkeley, CA |
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| Snippet | A magnetic resonance imaging study of human cadaver spines.
To investigate associations between cartilage endplate (CEP) thickness and disc degeneration.... A magnetic resonance imaging study of human cadaver spines.STUDY DESIGNA magnetic resonance imaging study of human cadaver spines.To investigate associations... |
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| SubjectTerms | Cartilage - diagnostic imaging Cartilage - pathology Echo-Planar Imaging - methods Female Humans Intervertebral Disc Degeneration - diagnostic imaging Intervertebral Disc Degeneration - pathology Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Male Middle Aged |
| Title | Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration |
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