Role of the immune modulator programmed cell death-1 during development and apoptosis of mouse retinal ganglion cells

Mammalian programmed cell death (PD)-1 is a membrane-associated receptor regulating the balance between T-cell activation, tolerance, and immunopathology; however, its role in neurons has not yet been defined. The hypothesis that PD-1 signaling actively promotes retinal ganglion cell (RGC) death wit...

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Bibliographic Details
Published in:	Investigative ophthalmology & visual science Vol. 50; no. 10; p. 4941
Main Authors:	Chen, Ling, Sham, Caroline W, Chan, Ann M, Francisco, Loise M, Wu, Yin, Mareninov, Sergey, Sharpe, Arlene H, Freeman, Gordon J, Yang, Xian-Jie, Braun, Jonathan, Gordon, Lynn K
Format:	Journal Article
Language:	English
Published:	United States 01.10.2009
Subjects:	Animals Animals, Newborn Antigens, Surface - physiology Apoptosis Apoptosis Regulatory Proteins - physiology B7-1 Antigen - metabolism B7-H1 Antigen Blotting, Western Cell Count Cell Survival Fluorescent Antibody Technique, Indirect Gene Expression Regulation, Developmental - physiology Ligands Lymphocyte Activation Membrane Glycoproteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Peptides - metabolism Programmed Cell Death 1 Ligand 2 Protein Programmed Cell Death 1 Receptor Retina - growth & development Retina - metabolism Retinal Ganglion Cells - metabolism Retinal Ganglion Cells - pathology Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Signal Transduction - physiology
ISSN:	1552-5783, 1552-5783
Online Access:	Get more information
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