Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM—Increased serum CIIM in subjects with severe radiographic osteoarthritis

In joint degenerative diseases, the collagens are degraded by matrix metalloproteinases and protein fragments are released to serum as potential biomarkers. A collagen type II specific neoepitope, CIIM, was identified (…RDGAAG 1053) by mass spectrometry. Two ELISAs against the neoepitope were develo...

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Bibliographic Details
Published in:	Clinical biochemistry Vol. 44; no. 5; pp. 423 - 429
Main Authors:	Bay-Jensen, Anne-Christine, Liu, Qi, Byrjalsen, Inger, Li, Yi, Wang, Jianxia, Pedersen, Christian, Leeming, Diana J., Dam, Erik B., Zheng, Qinlong, Qvist, Per, Karsdal, Morten A.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier Inc 01.04.2011 Elsevier
Subjects:	Aged Aged, 80 and over Biological and medical sciences Cartilage Collagen Type II - blood Diseases of the osteoarticular system ELISA Enzyme-Linked Immunosorbent Assay - methods Female Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Metalloproteases - blood Metalloproteinase Middle Aged Miscellaneous. Osteoarticular involvement in other diseases Neoepitope Osteoarthritis Osteoarthritis - blood Osteoarthritis - enzymology Serum CIIM Type II collagen MMP Cartilage OA Neoepitope Serum CIIM JSN Metalloproteinase Type II collagen Osteoarthritis ECM ELISA Diseases of the osteoarticular system Metalloendopeptidases Clinical biology Serum Degenerative disease Human Radiodiagnosis Enzyme Exploration Collagen type II Enzyme immunoassay Radiography Peptidases Articular cartilage Arthropathy Hydrolases Severe ELISA assay
ISSN:	0009-9120, 1873-2933, 1873-2933
Online Access:	Get full text
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