Is Competition the Default Configuration of Cross‐Sensory Interactions?

ABSTRACT Several theories have been proposed about the default configuration of the brain's networks underlying unisensory and multisensory processing abilities and the development of multisensory integration during childhood. Recent empirical findings from animal models and behavioral data col...

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Vydané v:The European journal of neuroscience Ročník 62; číslo 4; s. e70233 - n/a
Hlavní autori: Monti, Melissa, Molholm, Sophie, Foxe, John J., Cuppini, Cristiano
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: France Wiley Subscription Services, Inc 01.08.2025
John Wiley and Sons Inc
Predmet:
Animal models
Autism
autism spectrum disorder
Autism Spectrum Disorder - physiopathology
Autistic children
Brain - growth & development
Brain - physiology
Brain - physiopathology
Brain architecture
Child
Child, Preschool
Children
Computational neuroscience
Female
Humans
Male
Models, Neurological
multisensory integration
neurocomputational modelling
Sensory integration
Sensory systems
Special Issue
SPECIAL ISSUE ARTICLE
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typical development
multisensory integration
autism spectrum disorder
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neurocomputational modelling
typical development
ISSN:0953-816X, 1460-9568, 1460-9568
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Popis
Shrnutí:ABSTRACT Several theories have been proposed about the default configuration of the brain's networks underlying unisensory and multisensory processing abilities and the development of multisensory integration during childhood. Recent empirical findings from animal models and behavioral data collected from typically developing (TD) children and children with autism spectrum disorder (ASD), however, are consistent with the idea that in the immature brain, prior to systematic cross‐sensory exposures typically encountered in everyday life, the individual sensory systems interact in a competitive manner. Which neural architecture and mechanisms best describe the brain's naïve configuration are still unknown. To fill this gap, this study investigates how sensory modalities interact in the young brain by comparing the predictions of two alternative biologically plausible neuro‐computational models to empirical data. The neural substrates responsible for the altered development of multisensory integrative processes observed in ASD children are also investigated. Linking the framework suggested by empirical data to a plausible neural implementation, our results challenge the classical notion of cross‐sensory brain organization at birth, whereby the various sensory pathways do not initially interact. Instead, we suggest that direct inhibitory interactions between sensory modalities are taking place in the immature brain, and we suggest that these inhibitory interactions play a crucial role in the altered multisensory perceptual abilities of children with autism. Neurocomputational modelling suggests that early cross‐sensory interactions are inherently competitive. Replicating ASD behavioral data requires stronger cross‐sensory competition, consistent with the hypothesis of delayed maturation.
Bibliografia:Yoland Smith
Funding
Associate Editor
This work was supported by #NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006)—A multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022).
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Funding: This work was supported by #NEXTGENERATIONEU (NGEU) and funded by the Ministry of University and Research (MUR), National Recovery and Resilience Plan (NRRP), project MNESYS (PE0000006)—A multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022).
Associate Editor: Yoland Smith
ISSN:0953-816X
1460-9568
1460-9568
DOI:10.1111/ejn.70233