The role of Size-Specific Dose Estimate (SSDE) in patient-specific organ dose and cancer risk estimation in paediatric chest and abdominopelvic CT examinations

Objectives To develop a clinically applicable method to estimate patient-specific organ and blood doses and lifetime attributable risks (LAR) from paediatric torso CT examinations. Methods Individualized voxel models were created from full-body CT data of 10 paediatric patients (2–18 years). Patient...

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Vydáno v:European radiology Ročník 26; číslo 8; s. 2646 - 2655
Hlavní autoři: Franck, Caro, Vandevoorde, Charlot, Goethals, Ingeborg, Smeets, Peter, Achten, Eric, Verstraete, Koenraad, Thierens, Hubert, Bacher, Klaus
Médium: Journal Article
Jazyk:angličtina
Vydáno: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2016
Springer Nature B.V
Témata:
Abdomen - diagnostic imaging
Adolescent
Cancer
Child
Child, Preschool
Computer Simulation
Diagnostic Radiology
Dosimetry
Drug dosages
Female
Humans
Imaging
Internal Medicine
Interventional Radiology
Male
Medical imaging
Medicine
Medicine & Public Health
Models, Theoretical
Monte Carlo Method
Neoplasms, Radiation-Induced - epidemiology
Neoplasms, Radiation-Induced - etiology
Neuroradiology
Organs at Risk
Patients
Pediatrics
Pelvis - diagnostic imaging
Physics
Radiation
Radiation Dosage
Radiology
Thorax - diagnostic imaging
Tomography
Tomography, X-Ray Computed - adverse effects
Tomography, X-Ray Computed - methods
Ultrasound
Belgium
X-Ray computed tomography
Monte Carlo method
Radiation dosimetry
Patient-specific computational modelling
Paediatrics
ISSN:0938-7994, 1432-1084, 1432-1084
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Shrnutí:Objectives To develop a clinically applicable method to estimate patient-specific organ and blood doses and lifetime attributable risks (LAR) from paediatric torso CT examinations. Methods Individualized voxel models were created from full-body CT data of 10 paediatric patients (2–18 years). Patient-specific dose distributions of chest and abdominopelvic CT scans were simulated using Monte Carlo methods. Blood dose was calculated as a weighted sum of simulated organ doses. LAR of cancer incidence and mortality were estimated, according to BEIR-VII. A second simulation and blood dose calculation was performed using only the thoracic and abdominopelvic region of the original voxel models. For each simulation, the size-specific dose estimate (SSDE) was calculated. Results SSDE showed a significant strong linear correlation with organ dose (r > 0.8) and blood dose (r > 0.9) and LAR (r > 0.9). No significant differences were found between blood dose calculations with the full-body voxel models and the thoracic or abdominopelvic models. Conclusion Even though clinical CT images mostly do not cover the whole body of the patient, they can be used as a voxel model for blood dose calculation. In addition, SSDE can estimate patient-specific organ and blood doses and LAR in paediatric torso CT examinations. Key Points • Blood dose can be simulated using the patient’s clinical CT images. • SSDE estimates patient-specific organ/blood dose and LAR in paediatric CAP CT-examinations. • SSDE makes on-the-spot dose and LAR estimations possible in routine clinical practice.
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ISSN:0938-7994
1432-1084
1432-1084
DOI:10.1007/s00330-015-4091-7