Baicalein and baicalin as Zika virus inhibitors
At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and baicalin were found to be capable of downregulating ZIKV replication up to 10 hours postinfection, while prophylactic effects were evident in pre...
Uloženo v:
| Vydáno v: | Archives of virology Ročník 164; číslo 2; s. 585 - 593 |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Vienna
Springer Vienna
01.02.2019
Springer Nature B.V |
| Témata: | |
| ISSN: | 0304-8608, 1432-8798, 1432-8798 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and baicalin were found to be capable of downregulating ZIKV replication up to 10 hours postinfection, while prophylactic effects were evident in pre-treated cells. Baicalein exhibited its highest potency during intracellular ZIKV replication, whereas baicalin was most effective against virus entry. Our
in silico
interaction assays predicted that both compounds exhibited the strongest binding affinities towards ZIKV NS5, while the virus envelope glycoprotein was the least likely target protein. These findings serve as a crucial platform for further in-depth studies to decipher the underlying anti-ZIKV mechanism(s) of each compound. |
|---|---|
| AbstractList | At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and baicalin were found to be capable of downregulating ZIKV replication up to 10 hours postinfection, while prophylactic effects were evident in pre-treated cells. Baicalein exhibited its highest potency during intracellular ZIKV replication, whereas baicalin was most effective against virus entry. Our
in silico
interaction assays predicted that both compounds exhibited the strongest binding affinities towards ZIKV NS5, while the virus envelope glycoprotein was the least likely target protein. These findings serve as a crucial platform for further in-depth studies to decipher the underlying anti-ZIKV mechanism(s) of each compound. At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and baicalin were found to be capable of downregulating ZIKV replication up to 10 hours postinfection, while prophylactic effects were evident in pre-treated cells. Baicalein exhibited its highest potency during intracellular ZIKV replication, whereas baicalin was most effective against virus entry. Our in silico interaction assays predicted that both compounds exhibited the strongest binding affinities towards ZIKV NS5, while the virus envelope glycoprotein was the least likely target protein. These findings serve as a crucial platform for further in-depth studies to decipher the underlying anti-ZIKV mechanism(s) of each compound. At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and baicalin were found to be capable of downregulating ZIKV replication up to 10 hours postinfection, while prophylactic effects were evident in pre-treated cells. Baicalein exhibited its highest potency during intracellular ZIKV replication, whereas baicalin was most effective against virus entry. Our in silico interaction assays predicted that both compounds exhibited the strongest binding affinities towards ZIKV NS5, while the virus envelope glycoprotein was the least likely target protein. These findings serve as a crucial platform for further in-depth studies to decipher the underlying anti-ZIKV mechanism(s) of each compound.At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and baicalin were found to be capable of downregulating ZIKV replication up to 10 hours postinfection, while prophylactic effects were evident in pre-treated cells. Baicalein exhibited its highest potency during intracellular ZIKV replication, whereas baicalin was most effective against virus entry. Our in silico interaction assays predicted that both compounds exhibited the strongest binding affinities towards ZIKV NS5, while the virus envelope glycoprotein was the least likely target protein. These findings serve as a crucial platform for further in-depth studies to decipher the underlying anti-ZIKV mechanism(s) of each compound. |
| Author | Oo, Adrian Zandi, Keivan Sam, Sing Sin Bakar, Sazaly Abu Teoh, Boon Teong |
| Author_xml | – sequence: 1 givenname: Adrian surname: Oo fullname: Oo, Adrian organization: Tropical Infectious Disease Research and Education Centre, Department of Medical Microbiology, University of Malaya – sequence: 2 givenname: Boon Teong surname: Teoh fullname: Teoh, Boon Teong organization: Tropical Infectious Disease Research and Education Centre, Department of Medical Microbiology, University of Malaya – sequence: 3 givenname: Sing Sin surname: Sam fullname: Sam, Sing Sin organization: Tropical Infectious Disease Research and Education Centre, Department of Medical Microbiology, University of Malaya – sequence: 4 givenname: Sazaly Abu surname: Bakar fullname: Bakar, Sazaly Abu organization: Tropical Infectious Disease Research and Education Centre, Department of Medical Microbiology, University of Malaya – sequence: 5 givenname: Keivan surname: Zandi fullname: Zandi, Keivan email: keivan.zandi@emory.edu organization: Tropical Infectious Disease Research and Education Centre, Department of Medical Microbiology, University of Malaya, Laboratory of Biochemical Pharmacology, Department of Pediatrics, School of Medicine, Emory University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30392049$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkU1LxDAQhoOsuB_6A7xIwYuX6uSrTY-6-AULXvTiJaRpVrN20zVpBf-9qbuLsKASyDDD8w4z847RwDXOIHSM4RwD5BchfsBTwCJlIGjK9tAIM0pSkRdigEZAgaUiAzFE4xAWALFA-QEaxlAQYMUIXVwpq1VtrEuUq5LyO-uTkDzbN5V8WN-FxLpXW9q28eEQ7c9VHczRJk7Q08314_QunT3c3k8vZ6lmwNtUi3mWlUBZnjMg2PBcKFaVtNDM0ExTzbmmoGiFccEFycuCMD1ngONcWZUTOkFn674r37x3JrRyaYM2da2cabogCSEY-gf_o5gC8IzjIqKnO-ii6byLi0SKiIJyntFInWyorlyaSq68XSr_KbdXi0C-BrRvQvBmLrVtVWsb13pla4lB9v7ItT8y-iN7fySLSryj3Db_S0PWmhBZ92L8z9C_i74AT1icuw |
| CitedBy_id | crossref_primary_10_3390_antibiotics10081011 crossref_primary_10_1016_j_chemosphere_2020_127038 crossref_primary_10_1007_s11259_025_10899_2 crossref_primary_10_52711_0974_360X_2022_00849 crossref_primary_10_1080_13880209_2022_2074053 crossref_primary_10_1002_prp2_928 crossref_primary_10_1039_D0RA03774E crossref_primary_10_3390_biomedicines10040900 crossref_primary_10_3390_ijms26157046 crossref_primary_10_1016_j_aquaculture_2025_742116 crossref_primary_10_1016_j_jpba_2020_113721 crossref_primary_10_1016_j_phrs_2020_104890 crossref_primary_10_3389_fmicb_2021_710359 crossref_primary_10_3390_ph15121493 crossref_primary_10_1016_j_theriogenology_2021_11_007 crossref_primary_10_1016_j_joim_2024_09_003 crossref_primary_10_1016_j_ejmech_2023_115629 crossref_primary_10_3390_plants10061245 crossref_primary_10_1186_s12906_023_03858_4 crossref_primary_10_1002_advs_202203499 crossref_primary_10_3389_fphar_2021_742146 crossref_primary_10_3389_fvets_2025_1551501 crossref_primary_10_1002_vms3_960 crossref_primary_10_1016_j_cbi_2020_109218 crossref_primary_10_1186_s12906_023_03971_4 crossref_primary_10_4103_wjtcm_wjtcm_68_20 crossref_primary_10_1186_s12906_020_2880_2 crossref_primary_10_3390_microorganisms9050893 crossref_primary_10_3390_v17060817 crossref_primary_10_3390_ijms26010047 crossref_primary_10_1007_s12257_019_0354_5 crossref_primary_10_1007_s12672_025_02719_5 crossref_primary_10_2147_IJN_S315705 crossref_primary_10_3390_v15051211 crossref_primary_10_1016_j_bcp_2020_113962 crossref_primary_10_3390_microbiolres15020038 crossref_primary_10_1007_s00044_021_02718_5 crossref_primary_10_1007_s11103_025_01603_8 crossref_primary_10_1016_j_antiviral_2023_105739 crossref_primary_10_1016_j_indcrop_2025_121690 crossref_primary_10_1002_med_21891 crossref_primary_10_3389_fmicb_2019_02725 crossref_primary_10_1002_jmv_28243 crossref_primary_10_1016_j_bcp_2022_115279 crossref_primary_10_2174_0113816128320161240703092622 crossref_primary_10_1016_j_virs_2024_07_003 crossref_primary_10_1080_19390211_2021_2006387 crossref_primary_10_1016_j_bcp_2020_114302 crossref_primary_10_1016_j_jpha_2025_101399 crossref_primary_10_1038_s41598_023_32049_x crossref_primary_10_31083_j_fbl2709259 crossref_primary_10_1002_slct_202103301 crossref_primary_10_1016_j_jiph_2023_03_008 crossref_primary_10_1007_s10517_020_04776_y crossref_primary_10_1080_14756366_2021_1873977 crossref_primary_10_1038_s41598_019_52626_3 crossref_primary_10_1016_j_apsb_2020_06_008 crossref_primary_10_1016_j_aquaculture_2023_739530 crossref_primary_10_3390_immuno1010004 crossref_primary_10_1016_j_aquaculture_2025_742309 crossref_primary_10_2478_aoas_2021_0019 crossref_primary_10_1093_cei_uxac062 crossref_primary_10_1002_ptr_7669 crossref_primary_10_1016_j_pharmthera_2020_107671 crossref_primary_10_31482_mmsl_2021_020 crossref_primary_10_1080_22221751_2023_2174777 crossref_primary_10_1016_j_procbio_2020_05_030 crossref_primary_10_1007_s11094_021_02443_8 crossref_primary_10_1016_S1875_5364_23_60401_7 |
| Cites_doi | 10.1016/S0140-6736(17)31450-2 10.1038/s41598-018-27224-4 10.1016/j.virol.2017.12.032 10.1016/j.jep.2014.08.031 10.1016/j.celrep.2016.12.045 10.1016/j.virol.2016.06.012 10.1039/C6RA00817H 10.12659/MSM.909722 10.3390/ijms19041093 10.1186/1472-6882-12-214 10.1016/j.virol.2018.03.009 10.1016/j.jaut.2016.02.006 10.3855/jidc.8217 10.1128/JVI.02019-17 10.1016/j.ijpharm.2016.02.039 10.1007/s00381-017-3637-1 10.7717/peerj.2602 10.1186/s13690-017-0233-5 10.1016/j.addr.2017.01.006 10.1038/s41419-018-0318-2 10.1016/j.antiviral.2016.11.023 10.1007/s12272-018-1022-6 10.1007/s00018-018-2751-x 10.1155/2015/263630 10.1016/j.antiviral.2017.12.012 10.1006/bbrc.2000.3485 10.1038/srep40920 10.1038/srep05452 10.3390/ijms131216785 10.1097/GRF.0000000000000343 10.1016/j.antiviral.2017.02.002 10.1016/j.antiviral.2017.03.014 |
| ContentType | Journal Article |
| Copyright | Springer-Verlag GmbH Austria, part of Springer Nature 2018 Archives of Virology is a copyright of Springer, (2018). All Rights Reserved. |
| Copyright_xml | – notice: Springer-Verlag GmbH Austria, part of Springer Nature 2018 – notice: Archives of Virology is a copyright of Springer, (2018). All Rights Reserved. |
| DBID | AAYXX CITATION NPM 3V. 7TK 7TM 7U9 7X7 7XB 88A 88E 8AO 8C1 8FD 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI CCPQU DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P64 PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 7X8 7S9 L.6 |
| DOI | 10.1007/s00705-018-4083-4 |
| DatabaseName | CrossRef PubMed ProQuest Central (Corporate) Neurosciences Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Biology Database (Alumni Edition) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials - QC Biological Science Collection ProQuest Central Natural Science Collection ProQuest One ProQuest Central Korea Engineering Research Database ProQuest Health & Medical Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) ProQuest Biological Science Collection Health & Medical Collection (Alumni Edition) Medical Database Biological Science Database Biotechnology and BioEngineering Abstracts Proquest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef PubMed ProQuest Central Student Technology Research Database ProQuest One Academic Middle East (New) ProQuest Central Essentials Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central China ProQuest Biology Journals (Alumni Edition) ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Genetics Abstracts Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Public Health Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection Neurosciences Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA MEDLINE - Academic PubMed ProQuest Central Student |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1432-8798 |
| EndPage | 593 |
| ExternalDocumentID | 30392049 10_1007_s00705_018_4083_4 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: Institut Pengurusan dan Pemantauan Penyelidikan, Universiti Malaya grantid: PG151-2016A funderid: http://dx.doi.org/10.13039/501100004781 – fundername: Institut Pengurusan dan Pemantauan Penyelidikan, Universiti Malaya grantid: PG151-2016A |
| GroupedDBID | --- -4W -56 -5G -BR -EM -~C -~X .86 .VR 06C 06D 0R~ 0VY 199 1N0 203 23N 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2~H 30V 36B 4.4 406 408 409 40D 40E 5VS 67N 67Z 6NX 78A 7X7 88A 88E 8AO 8C1 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X A8Z AAAVM AABHQ AACDK AAHBH AAHNG AAIAL AAJBT AAJKR AANZL AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABUWG ABWNU ABXPI ACAOD ACDTI ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACZOJ ADBBV ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEFQL AEGAL AEGNC AEJHL AEJRE AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AOCGG ARMRJ AXYYD AZFZN B-. BA0 BBNVY BDATZ BENPR BGNMA BHPHI BPHCQ BSONS BVXVI CCPQU CSCUP DDRTE DL5 DNIVK DPUIP EBD EBLON EBS EIOEI EJD EMB EMOBN EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GXS HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KPH LAS LK8 LLZTM M0L M1P M4Y M7P MA- N9A NB0 NPVJJ NQJWS NU0 O93 O9G O9I O9J OAM P19 P2P PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R89 R9I RHV RNS ROL RPX RRX RSV S16 S27 S3A S3B SAP SBL SBY SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 TSG TSK TSV TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WJK WK8 Y6R YLTOR Z45 Z7U Z7V Z7W Z7Y Z82 Z83 Z87 Z8O Z8P Z8Q Z8S Z8V Z8W Z91 Z92 ZMTXR ZOVNA ~EX ~KM -Y2 .GJ 2.D 28- 2P1 2VQ 3O- 3SX 53G 5QI AANXM AAPKM AARHV AAYTO AAYXX ABBRH ABDBE ABFSG ABQSL ABRTQ ABULA ACBXY ACSTC ADHKG ADYPR AEBTG AEFIE AEKMD AEZWR AFDZB AFEXP AFFHD AFFNX AFGCZ AFHIU AFOHR AGGDS AGJBK AGQPQ AHPBZ AHWEU AIXLP AJBLW ATHPR AYFIA BBWZM CAG CITATION COF EN4 ESTFP H13 KOW N2Q NDZJH O9- PHGZM PHGZT PJZUB PPXIY PQGLB RNI RZK S1Z S26 S28 SCLPG T16 WK6 ZGI 3V. NPM RIG 7TK 7TM 7U9 7XB 8FD 8FK AZQEC DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 7X8 PUEGO 7S9 L.6 |
| ID | FETCH-LOGICAL-c405t-c8f66b034774021e578a4db39c4e36c3c55c30a3d1195827b924cf4013926d723 |
| IEDL.DBID | M7P |
| ISICitedReferencesCount | 81 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000458284300024&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0304-8608 1432-8798 |
| IngestDate | Wed Oct 01 14:56:31 EDT 2025 Sun Sep 28 02:24:19 EDT 2025 Thu Nov 06 14:24:18 EST 2025 Wed Feb 19 02:34:20 EST 2025 Sat Nov 29 03:58:44 EST 2025 Tue Nov 18 22:23:32 EST 2025 Fri Feb 21 02:41:09 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c405t-c8f66b034774021e578a4db39c4e36c3c55c30a3d1195827b924cf4013926d723 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 30392049 |
| PQID | 2128935563 |
| PQPubID | 48320 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_2221010100 proquest_miscellaneous_2130056519 proquest_journals_2128935563 pubmed_primary_30392049 crossref_citationtrail_10_1007_s00705_018_4083_4 crossref_primary_10_1007_s00705_018_4083_4 springer_journals_10_1007_s00705_018_4083_4 |
| PublicationCentury | 2000 |
| PublicationDate | 20190201 2019-2-00 2019-Feb |
| PublicationDateYYYYMMDD | 2019-02-01 |
| PublicationDate_xml | – month: 2 year: 2019 text: 20190201 day: 1 |
| PublicationDecade | 2010 |
| PublicationPlace | Vienna |
| PublicationPlace_xml | – name: Vienna – name: Austria – name: Wien |
| PublicationSubtitle | Official Journal of the Virology Division of the International Union of Microbiological Societies |
| PublicationTitle | Archives of virology |
| PublicationTitleAbbrev | Arch Virol |
| PublicationTitleAlternate | Arch Virol |
| PublicationYear | 2019 |
| Publisher | Springer Vienna Springer Nature B.V |
| Publisher_xml | – name: Springer Vienna – name: Springer Nature B.V |
| References | Chu M, Xu L, Zhang M-b, Chu Z-y, Wang Y-d (2015) Role of Baicalin in anti-influenza virus A as a potent inducer of IFN-gamma. BioMed research international 2015 CarneiroBMBatistaMNBragaACSNogueiraMLRahalPThe green tea molecule EGCG inhibits Zika virus entryVirology201649621521810.1016/j.virol.2016.06.0121:CAS:528:DC%2BC28XhtVOgu7rE27344138 SacramentoCQDe MeloGRDe FreitasCSRochaNHoelzLVBMirandaMFintelman-RodriguesNMarttorelliAFerreiraACBarbosa-LimaGThe clinically approved antiviral drug sofosbuvir inhibits Zika virus replicationSci Rep201774092010.1038/srep409201:CAS:528:DC%2BC2sXhsVantL4%3D280982535241873 ZandiKTeohB-TSamS-SWongP-FMustafaMRAbuBakarSNovel antiviral activity of baicalein against dengue virusBMC Complement Altern Med201212121410.1186/1472-6882-12-2141:CAS:528:DC%2BC3sXhsFOqtbg%3D231401773528482 GooLDeMasoCRPelcRSLedgerwoodJEGrahamBSKuhnRJPiersonTCThe Zika virus envelope protein glycan loop regulates virion antigenicityVirology201851519120210.1016/j.virol.2017.12.0321:CAS:528:DC%2BC1cXis1yrug%3D%3D29304471 OoAHassandarvishPChinSPLeeVSBakarSAZandiKIn silico study on anti-Chikungunya virus activity of hesperetinPeerJ20164e260210.7717/peerj.26021:CAS:528:DC%2BC1cXpvVGitr0%3D278124125088613 PechenovSBhattacharjeeHYinDMittalSSubramonyJAImproving drug-like properties of insulin and GLP-1 via molecule design and formulation and improving diabetes management with device & drug deliveryAdv Drug Deliv Rev201711210612210.1016/j.addr.2017.01.0061:CAS:528:DC%2BC2sXltVajsL0%3D28153578 FangueiroJFCalpenaACClaresBAndreaniTEgeaMAVeigaFJGarciaMLSilvaAMSoutoEBBiopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): in vivo, in vitro and ex vivo studiesInt J Pharm20165021–216116910.1016/j.ijpharm.2016.02.0391:CAS:528:DC%2BC28XjslShur8%3D26921515 HeukelbachJAlencarCHKelvinAAde OliveiraWKde Góes CavalcantiLPZika virus outbreak in BrazilJ Infect Dev Ctries2016100211612010.3855/jidc.821726927450 Bullard-FeibelmanKMGoveroJZhuZSalazarVVeselinovicMDiamondMSGeissBJThe FDA-approved drug sofosbuvir inhibits Zika virus infectionAntivir Res201713713414010.1016/j.antiviral.2016.11.0231:CAS:528:DC%2BC28XitFGisrfN27902933 MeertensLLabeauADejarnacOCiprianiSSinigagliaLBonnet-MadinLLe CharpentierTHafirassouMLZamborliniACao-LormeauV-MAxl mediates ZIKA virus entry in human glial cells and modulates innate immune responsesCell Rep201718232433310.1016/j.celrep.2016.12.0451:CAS:528:DC%2BC2sXhtVCjuro%3D28076778 HassandarvishPRothanHARezaeiSYusofRAbubakarSZandiKIn silico study on baicalein and baicalin as inhibitors of dengue virus replicationRSC Adv2016637312353124710.1039/C6RA00817H1:CAS:528:DC%2BC28XjvFyqsLY%3D MéndezNOviedo-PastranaMMattarSCaicedo-CastroIArrietaGZika virus disease, microcephaly and Guillain-Barré syndrome in Colombia: epidemiological situation during 21 months of the Zika virus outbreak, 2015–2017Arch Public Health20177516510.1186/s13690-017-0233-5291189815667031 LiuJLvS-SFuZ-YHouL-LBaicalein enhances migration and invasion of extravillous trophoblasts via activation of the NF-κB pathwayMed Sci Monit201824298310.12659/MSM.9097221:CAS:528:DC%2BC1MXhsVGjt7vF297359735963314 Baud D, Gubler DJ, Schaub B, Lanteri MC, Musso D (2017) An update on Zika virus infection. The Lancet 390:2099–2109 ChengFda SilvaSRHuangI-CJungJUGaoS-JSuppression of Zika virus infection and replication in endothelial cells and astrocytes by PKA inhibitor PKI 14-22J Virol2018924e02019–02017 ChanJF-WChikKK-HYuanSYipCC-YZhuZTeeK-MTsangJO-LChanCC-SPoonVK-MLuGNovel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitorAntivir Res2017141293710.1016/j.antiviral.2017.02.0021:CAS:528:DC%2BC2sXivFWhu7w%3D28185815 JinJChenYWangDMaLGuoMZhouCDouJThe inhibitory effect of sodium baicalin on oseltamivir-resistant influenza A virus via reduction of neuraminidase activityArch Pharm Res201841666467610.1007/s12272-018-1022-61:CAS:528:DC%2BC1cXmsVaqtL0%3D29572682 MoghaddamETeohB-TSamS-SLaniRHassandarvishPChikZYuehAAbubakarSZandiKBaicalin, a metabolite of baicalein with antiviral activity against dengue virusSci Rep20144545210.1038/srep054521:CAS:528:DC%2BC2MXksVWiu7s%3D249655534071309 FinkSLVojtechLWagonerJSlivinskiNSJacksonKJWangRKhadkaSLuthraPBaslerCFPolyakSJThe antiviral drug arbidol inhibits Zika virusSci Rep201881898910.1038/s41598-018-27224-41:CAS:528:DC%2BC1cXhsl2is77E298959625997637 MounceBCCesaroTCarrauLValletTVignuzziMCurcumin inhibits Zika and chikungunya virus infection by inhibiting cell bindingAntivir Res201714214815710.1016/j.antiviral.2017.03.0141:CAS:528:DC%2BC2sXlsV2jtbw%3D28343845 PersaudMMartinez-LopezABuffoneCPorcelliSADiaz-GrifferoFInfection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pHVirology201851830131210.1016/j.virol.2018.03.0091:CAS:528:DC%2BC1cXlvVOntb8%3D29574335 WangGLiangJL-rGaoZ-pSiX-tZhangLiangGYanYLiKChengXBaoYBaicalin administration attenuates hyperglycemia-induced malformation of cardiovascular systemCell Death Dis20189223410.1038/s41419-018-0318-21:CAS:528:DC%2BC1cXhtVKnsr7P294450815833405 JohariJKianmehrAMustafaMRAbubakarSZandiKAntiviral activity of baicalein and quercetin against the Japanese encephalitis virusInt J Mol Sci20121312167851679510.3390/ijms1312167851:CAS:528:DC%2BC3sXht1eltA%3D%3D232226833546721 de SouzaASde Oliveira-SzjenfeldPSde Oliveira MeloASde SouzaLAMBatistaAGMTovar-MollFImaging findings in congenital Zika virus infection syndrome: an updateChild Nerv Syst2018341859310.1007/s00381-017-3637-1 OoARausaluKMeritsAHiggsSVanlandinghamDBakarSAZandiKDeciphering the potential of baicalin as an antiviral agent for Chikungunya virus infectionAntivir Res201815010111110.1016/j.antiviral.2017.12.0121:CAS:528:DC%2BC2sXitVWlsbfE29269135 LiBQFuTDongyanYMikovitsJARuscettiFWWangJMFlavonoid baicalin inhibits HIV-1 infection at the level of viral entryBiochem Biophys Res Commun2000276253453810.1006/bbrc.2000.34851:CAS:528:DC%2BD3cXntFOrsL0%3D11027509 WangBThurmondSHaiRSongJStructure and function of Zika virus NS5 protein: perspectives for drug designCell Mol Life Sci201875101723173610.1007/s00018-018-2751-x1:CAS:528:DC%2BC1cXisVKhurg%3D294235295911220 GaudryABosSViranaickenWRocheMKrejbich-TrototPGadeaGDesprèsPEl-KalamouniCThe flavonoid isoquercitrin precludes initiation of Zika virus infection in human cellsInt J Mol Sci2018194109310.3390/ijms190410931:CAS:528:DC%2BC1cXisVyjs7bL5979602 LiMShiAPangHXueWLiYCaoGYanBDongFLiKXiaoWSafety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjectsJ Ethnopharmacol201415621021510.1016/j.jep.2014.08.0311:CAS:528:DC%2BC2cXhsFGlurrJ25219601 ChangCOrtizKAnsariAGershwinMEThe Zika outbreak of the 21st centuryJ Autoimmun20166811310.1016/j.jaut.2016.02.00626925496 HoltzmanMGoldenWCSheffieldJSZika virus infection in the pregnant womanClin Obstet Gynecol201861117718529319591 JF-W Chan (4083_CR17) 2017; 141 K Zandi (4083_CR10) 2012; 12 A Oo (4083_CR12) 2018; 150 M Li (4083_CR28) 2014; 156 SL Fink (4083_CR21) 2018; 8 L Meertens (4083_CR26) 2017; 18 J Liu (4083_CR31) 2018; 24 AS Souza de (4083_CR6) 2018; 34 A Oo (4083_CR14) 2016; 4 JF Fangueiro (4083_CR29) 2016; 502 BM Carneiro (4083_CR9) 2016; 496 E Moghaddam (4083_CR11) 2014; 4 4083_CR27 G Wang (4083_CR32) 2018; 9 L Goo (4083_CR24) 2018; 515 M Holtzman (4083_CR5) 2018; 61 4083_CR1 N Méndez (4083_CR3) 2017; 75 S Pechenov (4083_CR30) 2017; 112 KM Bullard-Feibelman (4083_CR16) 2017; 137 CQ Sacramento (4083_CR23) 2017; 7 F Cheng (4083_CR20) 2018; 92 J Jin (4083_CR13) 2018; 41 P Hassandarvish (4083_CR15) 2016; 6 J Johari (4083_CR18) 2012; 13 M Persaud (4083_CR25) 2018; 518 A Gaudry (4083_CR7) 2018; 19 B Wang (4083_CR22) 2018; 75 BC Mounce (4083_CR8) 2017; 142 J Heukelbach (4083_CR2) 2016; 10 C Chang (4083_CR4) 2016; 68 BQ Li (4083_CR19) 2000; 276 |
| References_xml | – reference: ChanJF-WChikKK-HYuanSYipCC-YZhuZTeeK-MTsangJO-LChanCC-SPoonVK-MLuGNovel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitorAntivir Res2017141293710.1016/j.antiviral.2017.02.0021:CAS:528:DC%2BC2sXivFWhu7w%3D28185815 – reference: WangGLiangJL-rGaoZ-pSiX-tZhangLiangGYanYLiKChengXBaoYBaicalin administration attenuates hyperglycemia-induced malformation of cardiovascular systemCell Death Dis20189223410.1038/s41419-018-0318-21:CAS:528:DC%2BC1cXhtVKnsr7P294450815833405 – reference: GaudryABosSViranaickenWRocheMKrejbich-TrototPGadeaGDesprèsPEl-KalamouniCThe flavonoid isoquercitrin precludes initiation of Zika virus infection in human cellsInt J Mol Sci2018194109310.3390/ijms190410931:CAS:528:DC%2BC1cXisVyjs7bL5979602 – reference: SacramentoCQDe MeloGRDe FreitasCSRochaNHoelzLVBMirandaMFintelman-RodriguesNMarttorelliAFerreiraACBarbosa-LimaGThe clinically approved antiviral drug sofosbuvir inhibits Zika virus replicationSci Rep201774092010.1038/srep409201:CAS:528:DC%2BC2sXhsVantL4%3D280982535241873 – reference: HassandarvishPRothanHARezaeiSYusofRAbubakarSZandiKIn silico study on baicalein and baicalin as inhibitors of dengue virus replicationRSC Adv2016637312353124710.1039/C6RA00817H1:CAS:528:DC%2BC28XjvFyqsLY%3D – reference: GooLDeMasoCRPelcRSLedgerwoodJEGrahamBSKuhnRJPiersonTCThe Zika virus envelope protein glycan loop regulates virion antigenicityVirology201851519120210.1016/j.virol.2017.12.0321:CAS:528:DC%2BC1cXis1yrug%3D%3D29304471 – reference: WangBThurmondSHaiRSongJStructure and function of Zika virus NS5 protein: perspectives for drug designCell Mol Life Sci201875101723173610.1007/s00018-018-2751-x1:CAS:528:DC%2BC1cXisVKhurg%3D294235295911220 – reference: HeukelbachJAlencarCHKelvinAAde OliveiraWKde Góes CavalcantiLPZika virus outbreak in BrazilJ Infect Dev Ctries2016100211612010.3855/jidc.821726927450 – reference: FinkSLVojtechLWagonerJSlivinskiNSJacksonKJWangRKhadkaSLuthraPBaslerCFPolyakSJThe antiviral drug arbidol inhibits Zika virusSci Rep201881898910.1038/s41598-018-27224-41:CAS:528:DC%2BC1cXhsl2is77E298959625997637 – reference: PersaudMMartinez-LopezABuffoneCPorcelliSADiaz-GrifferoFInfection by Zika viruses requires the transmembrane protein AXL, endocytosis and low pHVirology201851830131210.1016/j.virol.2018.03.0091:CAS:528:DC%2BC1cXlvVOntb8%3D29574335 – reference: ChengFda SilvaSRHuangI-CJungJUGaoS-JSuppression of Zika virus infection and replication in endothelial cells and astrocytes by PKA inhibitor PKI 14-22J Virol2018924e02019–02017 – reference: PechenovSBhattacharjeeHYinDMittalSSubramonyJAImproving drug-like properties of insulin and GLP-1 via molecule design and formulation and improving diabetes management with device & drug deliveryAdv Drug Deliv Rev201711210612210.1016/j.addr.2017.01.0061:CAS:528:DC%2BC2sXltVajsL0%3D28153578 – reference: HoltzmanMGoldenWCSheffieldJSZika virus infection in the pregnant womanClin Obstet Gynecol201861117718529319591 – reference: LiMShiAPangHXueWLiYCaoGYanBDongFLiKXiaoWSafety, tolerability, and pharmacokinetics of a single ascending dose of baicalein chewable tablets in healthy subjectsJ Ethnopharmacol201415621021510.1016/j.jep.2014.08.0311:CAS:528:DC%2BC2cXhsFGlurrJ25219601 – reference: LiBQFuTDongyanYMikovitsJARuscettiFWWangJMFlavonoid baicalin inhibits HIV-1 infection at the level of viral entryBiochem Biophys Res Commun2000276253453810.1006/bbrc.2000.34851:CAS:528:DC%2BD3cXntFOrsL0%3D11027509 – reference: JinJChenYWangDMaLGuoMZhouCDouJThe inhibitory effect of sodium baicalin on oseltamivir-resistant influenza A virus via reduction of neuraminidase activityArch Pharm Res201841666467610.1007/s12272-018-1022-61:CAS:528:DC%2BC1cXmsVaqtL0%3D29572682 – reference: FangueiroJFCalpenaACClaresBAndreaniTEgeaMAVeigaFJGarciaMLSilvaAMSoutoEBBiopharmaceutical evaluation of epigallocatechin gallate-loaded cationic lipid nanoparticles (EGCG-LNs): in vivo, in vitro and ex vivo studiesInt J Pharm20165021–216116910.1016/j.ijpharm.2016.02.0391:CAS:528:DC%2BC28XjslShur8%3D26921515 – reference: ZandiKTeohB-TSamS-SWongP-FMustafaMRAbuBakarSNovel antiviral activity of baicalein against dengue virusBMC Complement Altern Med201212121410.1186/1472-6882-12-2141:CAS:528:DC%2BC3sXhsFOqtbg%3D231401773528482 – reference: Bullard-FeibelmanKMGoveroJZhuZSalazarVVeselinovicMDiamondMSGeissBJThe FDA-approved drug sofosbuvir inhibits Zika virus infectionAntivir Res201713713414010.1016/j.antiviral.2016.11.0231:CAS:528:DC%2BC28XitFGisrfN27902933 – reference: Baud D, Gubler DJ, Schaub B, Lanteri MC, Musso D (2017) An update on Zika virus infection. The Lancet 390:2099–2109 – reference: ChangCOrtizKAnsariAGershwinMEThe Zika outbreak of the 21st centuryJ Autoimmun20166811310.1016/j.jaut.2016.02.00626925496 – reference: CarneiroBMBatistaMNBragaACSNogueiraMLRahalPThe green tea molecule EGCG inhibits Zika virus entryVirology201649621521810.1016/j.virol.2016.06.0121:CAS:528:DC%2BC28XhtVOgu7rE27344138 – reference: Chu M, Xu L, Zhang M-b, Chu Z-y, Wang Y-d (2015) Role of Baicalin in anti-influenza virus A as a potent inducer of IFN-gamma. BioMed research international 2015 – reference: OoAHassandarvishPChinSPLeeVSBakarSAZandiKIn silico study on anti-Chikungunya virus activity of hesperetinPeerJ20164e260210.7717/peerj.26021:CAS:528:DC%2BC1cXpvVGitr0%3D278124125088613 – reference: JohariJKianmehrAMustafaMRAbubakarSZandiKAntiviral activity of baicalein and quercetin against the Japanese encephalitis virusInt J Mol Sci20121312167851679510.3390/ijms1312167851:CAS:528:DC%2BC3sXht1eltA%3D%3D232226833546721 – reference: MéndezNOviedo-PastranaMMattarSCaicedo-CastroIArrietaGZika virus disease, microcephaly and Guillain-Barré syndrome in Colombia: epidemiological situation during 21 months of the Zika virus outbreak, 2015–2017Arch Public Health20177516510.1186/s13690-017-0233-5291189815667031 – reference: MeertensLLabeauADejarnacOCiprianiSSinigagliaLBonnet-MadinLLe CharpentierTHafirassouMLZamborliniACao-LormeauV-MAxl mediates ZIKA virus entry in human glial cells and modulates innate immune responsesCell Rep201718232433310.1016/j.celrep.2016.12.0451:CAS:528:DC%2BC2sXhtVCjuro%3D28076778 – reference: de SouzaASde Oliveira-SzjenfeldPSde Oliveira MeloASde SouzaLAMBatistaAGMTovar-MollFImaging findings in congenital Zika virus infection syndrome: an updateChild Nerv Syst2018341859310.1007/s00381-017-3637-1 – reference: MounceBCCesaroTCarrauLValletTVignuzziMCurcumin inhibits Zika and chikungunya virus infection by inhibiting cell bindingAntivir Res201714214815710.1016/j.antiviral.2017.03.0141:CAS:528:DC%2BC2sXlsV2jtbw%3D28343845 – reference: MoghaddamETeohB-TSamS-SLaniRHassandarvishPChikZYuehAAbubakarSZandiKBaicalin, a metabolite of baicalein with antiviral activity against dengue virusSci Rep20144545210.1038/srep054521:CAS:528:DC%2BC2MXksVWiu7s%3D249655534071309 – reference: LiuJLvS-SFuZ-YHouL-LBaicalein enhances migration and invasion of extravillous trophoblasts via activation of the NF-κB pathwayMed Sci Monit201824298310.12659/MSM.9097221:CAS:528:DC%2BC1MXhsVGjt7vF297359735963314 – reference: OoARausaluKMeritsAHiggsSVanlandinghamDBakarSAZandiKDeciphering the potential of baicalin as an antiviral agent for Chikungunya virus infectionAntivir Res201815010111110.1016/j.antiviral.2017.12.0121:CAS:528:DC%2BC2sXitVWlsbfE29269135 – ident: 4083_CR1 doi: 10.1016/S0140-6736(17)31450-2 – volume: 8 start-page: 8989 issue: 1 year: 2018 ident: 4083_CR21 publication-title: Sci Rep doi: 10.1038/s41598-018-27224-4 – volume: 515 start-page: 191 year: 2018 ident: 4083_CR24 publication-title: Virology doi: 10.1016/j.virol.2017.12.032 – volume: 156 start-page: 210 year: 2014 ident: 4083_CR28 publication-title: J Ethnopharmacol doi: 10.1016/j.jep.2014.08.031 – volume: 18 start-page: 324 issue: 2 year: 2017 ident: 4083_CR26 publication-title: Cell Rep doi: 10.1016/j.celrep.2016.12.045 – volume: 496 start-page: 215 year: 2016 ident: 4083_CR9 publication-title: Virology doi: 10.1016/j.virol.2016.06.012 – volume: 6 start-page: 31235 issue: 37 year: 2016 ident: 4083_CR15 publication-title: RSC Adv doi: 10.1039/C6RA00817H – volume: 24 start-page: 2983 year: 2018 ident: 4083_CR31 publication-title: Med Sci Monit doi: 10.12659/MSM.909722 – volume: 19 start-page: 1093 issue: 4 year: 2018 ident: 4083_CR7 publication-title: Int J Mol Sci doi: 10.3390/ijms19041093 – volume: 12 start-page: 214 issue: 1 year: 2012 ident: 4083_CR10 publication-title: BMC Complement Altern Med doi: 10.1186/1472-6882-12-214 – volume: 518 start-page: 301 year: 2018 ident: 4083_CR25 publication-title: Virology doi: 10.1016/j.virol.2018.03.009 – volume: 68 start-page: 1 year: 2016 ident: 4083_CR4 publication-title: J Autoimmun doi: 10.1016/j.jaut.2016.02.006 – volume: 10 start-page: 116 issue: 02 year: 2016 ident: 4083_CR2 publication-title: J Infect Dev Ctries doi: 10.3855/jidc.8217 – volume: 92 start-page: e02019–02017 issue: 4 year: 2018 ident: 4083_CR20 publication-title: J Virol doi: 10.1128/JVI.02019-17 – volume: 502 start-page: 161 issue: 1–2 year: 2016 ident: 4083_CR29 publication-title: Int J Pharm doi: 10.1016/j.ijpharm.2016.02.039 – volume: 34 start-page: 85 issue: 1 year: 2018 ident: 4083_CR6 publication-title: Child Nerv Syst doi: 10.1007/s00381-017-3637-1 – volume: 4 start-page: e2602 year: 2016 ident: 4083_CR14 publication-title: PeerJ doi: 10.7717/peerj.2602 – volume: 75 start-page: 65 issue: 1 year: 2017 ident: 4083_CR3 publication-title: Arch Public Health doi: 10.1186/s13690-017-0233-5 – volume: 112 start-page: 106 year: 2017 ident: 4083_CR30 publication-title: Adv Drug Deliv Rev doi: 10.1016/j.addr.2017.01.006 – volume: 9 start-page: 234 issue: 2 year: 2018 ident: 4083_CR32 publication-title: Cell Death Dis doi: 10.1038/s41419-018-0318-2 – volume: 137 start-page: 134 year: 2017 ident: 4083_CR16 publication-title: Antivir Res doi: 10.1016/j.antiviral.2016.11.023 – volume: 41 start-page: 664 issue: 6 year: 2018 ident: 4083_CR13 publication-title: Arch Pharm Res doi: 10.1007/s12272-018-1022-6 – volume: 75 start-page: 1723 issue: 10 year: 2018 ident: 4083_CR22 publication-title: Cell Mol Life Sci doi: 10.1007/s00018-018-2751-x – ident: 4083_CR27 doi: 10.1155/2015/263630 – volume: 150 start-page: 101 year: 2018 ident: 4083_CR12 publication-title: Antivir Res doi: 10.1016/j.antiviral.2017.12.012 – volume: 276 start-page: 534 issue: 2 year: 2000 ident: 4083_CR19 publication-title: Biochem Biophys Res Commun doi: 10.1006/bbrc.2000.3485 – volume: 7 start-page: 40920 year: 2017 ident: 4083_CR23 publication-title: Sci Rep doi: 10.1038/srep40920 – volume: 4 start-page: 5452 year: 2014 ident: 4083_CR11 publication-title: Sci Rep doi: 10.1038/srep05452 – volume: 13 start-page: 16785 issue: 12 year: 2012 ident: 4083_CR18 publication-title: Int J Mol Sci doi: 10.3390/ijms131216785 – volume: 61 start-page: 177 issue: 1 year: 2018 ident: 4083_CR5 publication-title: Clin Obstet Gynecol doi: 10.1097/GRF.0000000000000343 – volume: 141 start-page: 29 year: 2017 ident: 4083_CR17 publication-title: Antivir Res doi: 10.1016/j.antiviral.2017.02.002 – volume: 142 start-page: 148 year: 2017 ident: 4083_CR8 publication-title: Antivir Res doi: 10.1016/j.antiviral.2017.03.014 |
| SSID | ssj0003035 |
| Score | 2.5340571 |
| Snippet | At present, there is no effective antiviral agent for Zika virus (ZIKV), an arbovirus that is known for its teratogenic effects on newborns. Baicalein and... |
| SourceID | proquest pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 585 |
| SubjectTerms | antiviral agents arboviruses Baicalin binding capacity Biomedical and Life Sciences Biomedicine Brief Report glycoproteins Infectious Diseases Medical Microbiology Neonates protective effect Replication Teratogenicity Virology Zika virus |
| SummonAdditionalLinks | – databaseName: Springer LINK Contemporary dbid: RSV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3dS8MwED90Kvji98d0SgWflGCXtGnyqKL4NMQvhi-lTVIsSifrNvC_99IvkelA6VPoJRx3udzvuOQO4NjVSlLVpYRTzQj644DElCUkZr7mXaUQIkRFs4mg1xP9vryt3nHn9W33OiVZnNTNYzdbmcZeNBMY8whcdx4W0NsJa41390_N8Ytnsl-mDjwiuCvqVOZPS3x3RlMIcyo7Wjid69V_sbsGKxXGdM7LTbEOcybbgKWy6-THJpxdRFYzJs2cKNNOXIzsIHee09fImaTDce6k2Usap7YXzxY8Xl89XN6Qqm8CUQi_RkSJhPPYZR5CO3ThBo0y8nTMpPIM44op31fMjZi25d4EDWKMwVRiAy1JuQ4o24ZWNsjMLjjoQhVLmOGym3jM1dKnOoiDQFHXcE29Nri1AENVFRW3vS3ewqYcciGHEOUQWjmEOOWkmfJeVtSYRdyptRJWxpWH6G2FLQvPWRuOmt9oFjbXEWVmMLY0tg4_R3w6g4ZivGs_tw07pcYbjnAXSYrRUxtOa_V-MfAru3t_ot6HZYRfsrwD3oHWaDg2B7CoJqM0Hx4Wu_oT37TrpQ priority: 102 providerName: Springer Nature |
| Title | Baicalein and baicalin as Zika virus inhibitors |
| URI | https://link.springer.com/article/10.1007/s00705-018-4083-4 https://www.ncbi.nlm.nih.gov/pubmed/30392049 https://www.proquest.com/docview/2128935563 https://www.proquest.com/docview/2130056519 https://www.proquest.com/docview/2221010100 |
| Volume | 164 |
| WOSCitedRecordID | wos000458284300024&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAVX databaseName: SpringerLink Contemporary customDbUrl: eissn: 1432-8798 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003035 issn: 0304-8608 databaseCode: RSV dateStart: 19970101 isFulltext: true titleUrlDefault: https://link.springer.com/search?facet-content-type=%22Journal%22 providerName: Springer Nature |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3dSxwxEB_0rNAXq63Ws-exgk8twVyym2SfREXx6Tj84ujLsptk6VLZ09s7of99J9kPKdJ7kYVA2ASGyWQ-MsNvAI6p0THTI0YEM5ygPZYkYzwnGY-MGGmNLkLqm03I8VhNp_GkeXCrmrLKVid6RW1m2r2Rn6CKVQ4LXPDTp2fiuka57GrTQmMdNhxKAvele5NOE6N6juosQkiUoKrNalIPIip92ZrCCEohlf_apTfO5ptEqbc_V5_eS_k2bDWeZ3BWi8oOrNnyM2zWvSj_fIGT89Sdly3KIC1NkPmZm1TBz-J3GrwU82UVFOWvIitch55duL-6vLu4Jk03BaLRKVsQrXIhMspDdPjQsFu8qmloMh7r0HKhuY4izWnKjQOBU0xmGJnp3IVfMRNGMr4HvXJW2n0I0LBqnnMr4lEecmriiBmZSakZtcKwsA-05WWiG6hx1_HiMelAkj37E2R_4tif4Jbv3ZanGmdj1eJBy-mkuXJV8srmPhx1v_GyuAxIWtrZ0q1x6PwCvdYVaxhGwe6jffhaH35HEQpUzDCm6sOPVhpeCfgvuQeryf0GH9ELi-tS8AH0FvOlPYQP-mVRVPMhrMup9KPCUV2MhrBxfjme3Ay9rON4c_vwFyqN-6E |
| linkProvider | ProQuest |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1LT9wwEB4h2goufQHttpSmElxAFl47cZxDVfUBAkFXHEBCXEJiO2pElaWbXSr-VH9jZ5xNEELsjQPKyYotjTzjmW8yznwA69yaRJi-YEpYyTAexywXsmC5jKzqG4MQIfNkE_FgoE9Pk6M5-Nf-C0PXKluf6B21HRr6Rr6NLlZTL3Alv1z-YcQaRdXVlkKjMYsDd_0XU7b68_4P1O-GELs7x9_32JRVgBkEJ2NmdKFUzmWIwAcDnEOTzUKby8SETiojTRQZyTNpqRmaFnGOGYopKA1JhLIxNTpAl_8EYYTQ_qrgUef5MRxETdUiZFpx3VZRuW9aGvtrchozNo27cjsO3gG3dwqzPt7tvnhsO_USnk-RdfC1OQqvYM5Vr-FZw7V5vQTb3zKyR1dWQVbZIPcjGtTBWXmRBVflaFIHZfWrzEtiIFqGkweRdgXmq2Hl3kKAwMHIQjqV9ItQcptEwsZ5HBvBnbIi7AFvdZeaaSt1YvT4nXZNoL26U1R3SupOcclmt-Sy6SMya_Jqq9l06lLq9EatPfjUvUZnQBWerHLDCc0h9gGFqHzGHIFZPj28B28aY-skQgNOBOaMPdhqre9GgHvFfTdb3I-wsHf88zA93B8cvIdFRJxJc-19FebHo4n7AE_N1bisR2v-NAVw_tBG-R9Pf0-M |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3fS9xAEB5E2-KL1lbtVVtTsC-V5fZ2k93kQaRVD8Vy-GBB-pImuxsMSs5e7iz-a_51zuTHHUV6bz6UPC3ZhSHzZeabzGQGYJdbEwnTE0wJKxn6Y81SITOWysCqnjFIEZJq2IQeDMLLy-h8AR7af2GorLK1iZWhtkND38i7aGJD6gWuZDdryiLOj_oHt78ZTZCiTGs7TqOGyJm7_4PhW7l_eoS6_ixE__ji8IQ1EwaYQaIyZibMlEq59JEEobNzCN_Et6mMjO-kMtIEgZE8kZYao4VCpxitmIxCkkgoq6npAZr_JS0RxfSX-uGsvARdQ1BnMHwWKh62GVVeNTDVVclciNFbiE_ob5_4hOg-SdJWvq-_-j8_tdew0jBu72v9iqzBgivewMt6Buf9W-h-SwinLi-8pLBeWq1oUXo_8-vEu8tHk9LLi6s8zWky0Tr8eBZpN2CxGBbuHXhIKIzMpFNRL_Mlt1EgrE61NoI7ZYXfAd7qMTZNi3Wa9HETT5tDV6qPUfUxqT7GI1-mR27r_iLzNm-3Wo4bU1PGMxV34NP0NhoJyvwkhRtOaA9NJVDI1ufsERj908U7sFkDbyoRgjkSGEt2YK9F4kyAf4r7fr64O_AKsRh_Px2cbcEyEtGorobfhsXxaOI-wAtzN87L0cfqxfLg13Nj8hGYIFgC |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Baicalein+and+baicalin+as+Zika+virus+inhibitors&rft.jtitle=Archives+of+virology&rft.au=Oo%2C+Adrian&rft.au=Teoh%2C+Boon+Teong&rft.au=Sam%2C+Sing+Sin&rft.au=Bakar%2C+Sazaly+Abu&rft.date=2019-02-01&rft.eissn=1432-8798&rft.volume=164&rft.issue=2&rft.spage=585&rft_id=info:doi/10.1007%2Fs00705-018-4083-4&rft_id=info%3Apmid%2F30392049&rft.externalDocID=30392049 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-8608&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-8608&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-8608&client=summon |