Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer

Cancer invasion and metastasis occur in a complex three-dimensional (3D) environment, with reciprocal feedback from the surrounding host tissue and vasculature-governing behavior. In this study, we used a novel intravital method that revealed spatiotemporal regulation of Src activity in response to...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Jg. 73; H. 15; S. 4674
Hauptverfasser:	Nobis, Max, McGhee, Ewan J, Morton, Jennifer P, Schwarz, Juliane P, Karim, Saadia A, Quinn, Jean, Edward, Mike, Campbell, Andrew D, McGarry, Lynn C, Evans, T R Jeffry, Brunton, Valerie G, Frame, Margaret C, Carragher, Neil O, Wang, Yingxiao, Sansom, Owen J, Timpson, Paul, Anderson, Kurt I
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.08.2013
Schlagworte:	Animals Antineoplastic Agents - pharmacology Biosensing Techniques - methods Cells, Cultured Dasatinib Disease Models, Animal Fluorescence Resonance Energy Transfer - methods Imaging, Three-Dimensional - methods Mice Mice, Transgenic Microscopy, Fluorescence Pancreatic Neoplasms - metabolism Pyrimidines - pharmacology src-Family Kinases - metabolism Thiazoles - pharmacology
ISSN:	1538-7445, 1538-7445
Online-Zugang:	Weitere Angaben
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