Mechanistic insights and potential therapeutic approaches for NUP98-rearranged hematologic malignancies

Nucleoporin 98 (NUP98) fusion oncoproteins are observed in a spectrum of hematologic malignancies, particularly pediatric leukemias with poor patient outcomes. Although wild-type full-length NUP98 is a member of the nuclear pore complex, the chromosomal translocations leading to NUP98 gene fusions i...

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Bibliographic Details

Published in:	Blood Vol. 136; no. 20; p. 2275
Main Authors:	Michmerhuizen, Nicole L, Klco, Jeffery M, Mullighan, Charles G
Format:	Journal Article
Language:	English
Published:	United States 12.11.2020
Subjects:	Animals Hematologic Neoplasms - genetics Humans Nuclear Pore Complex Proteins - genetics Oncogene Proteins, Fusion - genetics
ISSN:	1528-0020, 1528-0020
Online Access:	Get more information
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