Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents

Stroke is one of the leading causes of death and physical disability worldwide. The consequences of stroke injuries are profound and persistent, causing in considerable burden to both the individual patient and society. Current treatments for ischemic stroke injuries have proved inadequate, partly o...

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Vydáno v:Journal of stroke Ročník 19; číslo 2; s. 166 - 187
Hlavní autoři: Khoshnam, Seyed Esmaeil, Winlow, William, Farbood, Yaghoob, Moghaddam, Hadi Fathi, Farzaneh, Maryam
Médium: Journal Article
Jazyk:angličtina
Vydáno: Korea (South) Korean Stroke Society 01.05.2017
대한뇌졸중학회
Témata:
ischemia
micrornas
Review
stroke
신경과학
Ischemia
Stroke
MicroRNAs
ISSN:2287-6391, 1229-4101, 2287-6405
On-line přístup:Získat plný text
Tagy: Přidat tag
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Abstract Stroke is one of the leading causes of death and physical disability worldwide. The consequences of stroke injuries are profound and persistent, causing in considerable burden to both the individual patient and society. Current treatments for ischemic stroke injuries have proved inadequate, partly owing to an incomplete understanding of the cellular and molecular changes that occur following ischemic stroke. MicroRNAs (miRNA) are endogenously expressed RNA molecules that function to inhibit mRNA translation and have key roles in the pathophysiological processes contributing to ischemic stroke injuries. Potential therapeutic areas to compensate these pathogenic processes include promoting angiogenesis, neurogenesis and neuroprotection. Several miRNAs, and their target genes, are recognized to be involved in these recoveries and repair mechanisms. The capacity of miRNAs to simultaneously regulate several target genes underlies their unique importance in ischemic stroke therapeutics. In this Review, we focus on the role of miRNAs as potential diagnostic and prognostic biomarkers, as well as promising therapeutic agents in cerebral ischemic stroke.
AbstractList Stroke is one of the leading causes of death and physical disability worldwide. The consequences of stroke injuries are profound and persistent, causing in considerable burden to both the individual patient and society. Current treatments for ischemic stroke injuries have proved inadequate, partly owing to an incomplete understanding of the cellular and molecular changes that occur following ischemic stroke. MicroRNAs (miRNA) are endogenously expressed RNA molecules that function to inhibit mRNA translation and have key roles in the pathophysiological processes contributing to ischemic stroke injuries. Potential therapeutic areas to compensate these pathogenic processes include promoting angiogenesis, neurogenesis and neuroprotection. Several miRNAs, and their target genes, are recognized to be involved in these recoveries and repair mechanisms. The capacity of miRNAs to simultaneously regulate several target genes underlies their unique importance in ischemic stroke therapeutics. In this Review, we focus on the role of miRNAs as potential diagnostic and prognostic biomarkers, as well as promising therapeutic agents in cerebral ischemic stroke.Stroke is one of the leading causes of death and physical disability worldwide. The consequences of stroke injuries are profound and persistent, causing in considerable burden to both the individual patient and society. Current treatments for ischemic stroke injuries have proved inadequate, partly owing to an incomplete understanding of the cellular and molecular changes that occur following ischemic stroke. MicroRNAs (miRNA) are endogenously expressed RNA molecules that function to inhibit mRNA translation and have key roles in the pathophysiological processes contributing to ischemic stroke injuries. Potential therapeutic areas to compensate these pathogenic processes include promoting angiogenesis, neurogenesis and neuroprotection. Several miRNAs, and their target genes, are recognized to be involved in these recoveries and repair mechanisms. The capacity of miRNAs to simultaneously regulate several target genes underlies their unique importance in ischemic stroke therapeutics. In this Review, we focus on the role of miRNAs as potential diagnostic and prognostic biomarkers, as well as promising therapeutic agents in cerebral ischemic stroke.
Stroke is one of the leading causes of death and physical disability worldwide. The consequences of stroke injuries are profound and persistent, causing in considerable burden to both the individual patient and society. Current treatments for ischemic stroke injuries have proved inadequate, partly owing to an incomplete understanding of the cellular and molecular changes that occur following ischemic stroke. MicroRNAs (miRNA) are endogenously expressed RNA molecules that function to inhibit mRNA translation and have key roles in the pathophysiological processes contributing to ischemic stroke injuries. Potential therapeutic areas to compensate these pathogenic processes include promoting angiogenesis, neurogenesis and neuroprotection. Several miRNAs, and their target genes, are recognized to be involved in these recoveries and repair mechanisms. The capacity of miRNAs to simultaneously regulate several target genes underlies their unique importance in ischemic stroke therapeutics. In this Review, we focus on the role of miRNAs as potential diagnostic and prognostic biomarkers, as well as promising therapeutic agents in cerebral ischemic stroke.
Stroke is one of the leading causes of death and physical disability worldwide. The consequences ofstroke injuries are profound and persistent, causing in considerable burden to both the individualpatient and society. Current treatments for ischemic stroke injuries have proved inadequate, partlyowing to an incomplete understanding of the cellular and molecular changes that occur followingischemic stroke. MicroRNAs (miRNA) are endogenously expressed RNA molecules that function toinhibit mRNA translation and have key roles in the pathophysiological processes contributing toischemic stroke injuries. Potential therapeutic areas to compensate these pathogenic processes includepromoting angiogenesis, neurogenesis and neuroprotection. Several miRNAs, and their targetgenes, are recognized to be involved in these recoveries and repair mechanisms. The capacity ofmiRNAs to simultaneously regulate several target genes underlies their unique importance in ischemicstroke therapeutics. In this Review, we focus on the role of miRNAs as potential diagnosticand prognostic biomarkers, as well as promising therapeutic agents in cerebral ischemic stroke. KCI Citation Count: 0
Author Khoshnam, Seyed Esmaeil
Winlow, William
Farbood, Yaghoob
Farzaneh, Maryam
Moghaddam, Hadi Fathi
Author_xml – sequence: 1
  givenname: Seyed Esmaeil
  surname: Khoshnam
  fullname: Khoshnam, Seyed Esmaeil
– sequence: 2
  givenname: William
  surname: Winlow
  fullname: Winlow, William
– sequence: 3
  givenname: Yaghoob
  surname: Farbood
  fullname: Farbood, Yaghoob
– sequence: 4
  givenname: Hadi Fathi
  surname: Moghaddam
  fullname: Moghaddam, Hadi Fathi
– sequence: 5
  givenname: Maryam
  surname: Farzaneh
  fullname: Farzaneh, Maryam
BackLink https://www.ncbi.nlm.nih.gov/pubmed/28480877$$D View this record in MEDLINE/PubMed
https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002227915$$DAccess content in National Research Foundation of Korea (NRF)
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DocumentTitleAlternate Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents
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Issue 2
Keywords Ischemia
Stroke
MicroRNAs
Language English
License This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Snippet Stroke is one of the leading causes of death and physical disability worldwide. The consequences of stroke injuries are profound and persistent, causing in...
Stroke is one of the leading causes of death and physical disability worldwide. The consequences ofstroke injuries are profound and persistent, causing in...
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SubjectTerms ischemia
micrornas
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stroke
신경과학
Title Emerging Roles of microRNAs in Ischemic Stroke: As Possible Therapeutic Agents
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