Investigating the Migraine Cycle over 21 Consecutive Days Using Proton Magnetic Resonance Spectroscopy and Resting-State fMRI: A Pilot Study

Recent neuroimaging studies have revealed important aspects of the underlying pathophysiological mechanisms of migraine suggesting abnormal brain energy metabolism and altered functional connectivity. Proton magnetic resonance spectroscopy (1H-MRS) studies investigated migraine patients in the inter...

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Veröffentlicht in:Brain sciences Jg. 12; H. 5; S. 646
Hauptverfasser: Filippi, Vera, Steiger, Ruth, Beliveau, Vincent, Frank, Florian, Kaltseis, Katharina, Gizewski, Elke R., Broessner, Gregor
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Switzerland MDPI AG 14.05.2022
MDPI
Schlagworte:
1H-MRS
attacks
Basal ganglia
Biomarkers
Brain
Brain mapping
Cell membranes
Creatine
Energy metabolism
Functional magnetic resonance imaging
Globus pallidus
Headache
Headaches
Magnetic resonance spectroscopy
Membrane turnover
Metabolism
Metabolites
Migraine
migraine cycle
N-Acetylaspartate
Neural networks
Neuroimaging
Neuromodulation
Occipital lobe
Pain
Patients
resting-state fMRI
Signal to noise ratio
Software
Spectrum analysis
Statistical analysis
Thalamus
1H-MRS
migraine cycle
resting-state fMRI
attacks
ISSN:2076-3425, 2076-3425
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Abstract Recent neuroimaging studies have revealed important aspects of the underlying pathophysiological mechanisms of migraine suggesting abnormal brain energy metabolism and altered functional connectivity. Proton magnetic resonance spectroscopy (1H-MRS) studies investigated migraine patients in the interictal or ictal state. This first-of-its-kind study aimed to investigate the whole migraine cycle using 1H-MRS and resting-state functional magnetic resonance imaging (fMRI). A migraine patient underwent 1H-MRS and resting-state fMRI for 21 consecutive days, regardless of whether he was in an interictal or ictal state. Metabolite ratios were assessed and compared to the intrinsic connectivity of subcortical brain areas. Probable migraine phase-dependent changes in N-acetyl aspartate (NAA)/total creatine (tCr) and choline (Cho)/tCr levels are found in the left occipital lobe and left basal ganglia. NAA reflects neuronal integrity and Cho cellular membrane turnover. Such abnormalities may increase the susceptibility to excitatory migraine triggers. Functional connectivity between the right hippocampus and right or left pallidum was strongly correlated to the NAA/Cho ratio in the right thalamus, suggesting neurochemical modulation of these brain areas through thalamic connections. To draw statistically significant conclusions a larger cohort is needed.
AbstractList Recent neuroimaging studies have revealed important aspects of the underlying pathophysiological mechanisms of migraine suggesting abnormal brain energy metabolism and altered functional connectivity. Proton magnetic resonance spectroscopy (1H-MRS) studies investigated migraine patients in the interictal or ictal state. This first-of-its-kind study aimed to investigate the whole migraine cycle using 1H-MRS and resting-state functional magnetic resonance imaging (fMRI). A migraine patient underwent 1H-MRS and resting-state fMRI for 21 consecutive days, regardless of whether he was in an interictal or ictal state. Metabolite ratios were assessed and compared to the intrinsic connectivity of subcortical brain areas. Probable migraine phase-dependent changes in N-acetyl aspartate (NAA)/total creatine (tCr) and choline (Cho)/tCr levels are found in the left occipital lobe and left basal ganglia. NAA reflects neuronal integrity and Cho cellular membrane turnover. Such abnormalities may increase the susceptibility to excitatory migraine triggers. Functional connectivity between the right hippocampus and right or left pallidum was strongly correlated to the NAA/Cho ratio in the right thalamus, suggesting neurochemical modulation of these brain areas through thalamic connections. To draw statistically significant conclusions a larger cohort is needed.
Recent neuroimaging studies have revealed important aspects of the underlying pathophysiological mechanisms of migraine suggesting abnormal brain energy metabolism and altered functional connectivity. Proton magnetic resonance spectroscopy (1H-MRS) studies investigated migraine patients in the interictal or ictal state. This first-of-its-kind study aimed to investigate the whole migraine cycle using 1H-MRS and resting-state functional magnetic resonance imaging (fMRI). A migraine patient underwent 1H-MRS and resting-state fMRI for 21 consecutive days, regardless of whether he was in an interictal or ictal state. Metabolite ratios were assessed and compared to the intrinsic connectivity of subcortical brain areas. Probable migraine phase-dependent changes in N-acetyl aspartate (NAA)/total creatine (tCr) and choline (Cho)/tCr levels are found in the left occipital lobe and left basal ganglia. NAA reflects neuronal integrity and Cho cellular membrane turnover. Such abnormalities may increase the susceptibility to excitatory migraine triggers. Functional connectivity between the right hippocampus and right or left pallidum was strongly correlated to the NAA/Cho ratio in the right thalamus, suggesting neurochemical modulation of these brain areas through thalamic connections. To draw statistically significant conclusions a larger cohort is needed.Recent neuroimaging studies have revealed important aspects of the underlying pathophysiological mechanisms of migraine suggesting abnormal brain energy metabolism and altered functional connectivity. Proton magnetic resonance spectroscopy (1H-MRS) studies investigated migraine patients in the interictal or ictal state. This first-of-its-kind study aimed to investigate the whole migraine cycle using 1H-MRS and resting-state functional magnetic resonance imaging (fMRI). A migraine patient underwent 1H-MRS and resting-state fMRI for 21 consecutive days, regardless of whether he was in an interictal or ictal state. Metabolite ratios were assessed and compared to the intrinsic connectivity of subcortical brain areas. Probable migraine phase-dependent changes in N-acetyl aspartate (NAA)/total creatine (tCr) and choline (Cho)/tCr levels are found in the left occipital lobe and left basal ganglia. NAA reflects neuronal integrity and Cho cellular membrane turnover. Such abnormalities may increase the susceptibility to excitatory migraine triggers. Functional connectivity between the right hippocampus and right or left pallidum was strongly correlated to the NAA/Cho ratio in the right thalamus, suggesting neurochemical modulation of these brain areas through thalamic connections. To draw statistically significant conclusions a larger cohort is needed.
Author Kaltseis, Katharina
Gizewski, Elke R.
Steiger, Ruth
Beliveau, Vincent
Broessner, Gregor
Filippi, Vera
Frank, Florian
AuthorAffiliation 3 Department of Neuroradiology, Innsbruck Medical University, 6020 Innsbruck, Austria; elke.gizewski@i-med.ac.at
2 Neuroimaging Research Core Facility, Innsbruck Medical University, 6020 Innsbruck, Austria; ruth.steiger@i-med.ac.at
1 Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria; vera.filippi@i-med.ac.at (V.F.); vincent.beliveau@i-med.ac.at (V.B.); f.frank@i-med.ac.at (F.F.); katharina.kaltseis@i-med.ac.at (K.K.)
AuthorAffiliation_xml – name: 3 Department of Neuroradiology, Innsbruck Medical University, 6020 Innsbruck, Austria; elke.gizewski@i-med.ac.at
– name: 2 Neuroimaging Research Core Facility, Innsbruck Medical University, 6020 Innsbruck, Austria; ruth.steiger@i-med.ac.at
– name: 1 Department of Neurology, Innsbruck Medical University, 6020 Innsbruck, Austria; vera.filippi@i-med.ac.at (V.F.); vincent.beliveau@i-med.ac.at (V.B.); f.frank@i-med.ac.at (F.F.); katharina.kaltseis@i-med.ac.at (K.K.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35625032$$D View this record in MEDLINE/PubMed
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Issue 5
Keywords 1H-MRS
migraine cycle
resting-state fMRI
attacks
Language English
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SubjectTerms 1H-MRS
attacks
Basal ganglia
Biomarkers
Brain
Brain mapping
Cell membranes
Creatine
Energy metabolism
Functional magnetic resonance imaging
Globus pallidus
Headache
Headaches
Magnetic resonance spectroscopy
Membrane turnover
Metabolism
Metabolites
Migraine
migraine cycle
N-Acetylaspartate
Neural networks
Neuroimaging
Neuromodulation
Occipital lobe
Pain
Patients
resting-state fMRI
Signal to noise ratio
Software
Spectrum analysis
Statistical analysis
Thalamus
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