Levodopa-induced dyskinesia in MPTP-treated macaques is not dependent on the extent and pattern of nigrostrial lesioning

The extent of nigrostriatal denervation is presumed to play a role in the genesis of levodopa‐induced dyskinesia. Yet some parkinsonian patients who have been treated over a long period do not develop dyskinesia, raising the possibility that the pattern of denervation is as important as the extent o...

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Bibliographic Details
Published in:	The European journal of neuroscience Vol. 22; no. 1; pp. 283 - 287
Main Authors:	Guigoni, Céline, Dovero, Sandra, Aubert, Incarnation, Li, Qin, Bioulac, Bernard H., Bloch, Bertrand, Gurevich, Eugenia V., Gross, Christian E., Bezard, Erwan
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Science Ltd 01.07.2005
Subjects:	Animals Antiparkinson Agents - adverse effects Cell Count Cell Death - drug effects Cell Death - physiology Corpus Striatum - metabolism Corpus Striatum - pathology Corpus Striatum - physiopathology Disease Models, Animal Dopamine - metabolism Dopamine Plasma Membrane Transport Proteins dopamine transporter Dyskinesia, Drug-Induced - pathology Dyskinesia, Drug-Induced - physiopathology Female Immunohistochemistry Levodopa - adverse effects Macaca fascicularis Membrane Glycoproteins - metabolism Membrane Transport Proteins - metabolism Nerve Degeneration - chemically induced Nerve Degeneration - pathology Nerve Degeneration - physiopathology Nerve Tissue Proteins - metabolism Neural Pathways - metabolism Neural Pathways - pathology Neural Pathways - physiopathology Neurons - metabolism Neurons - pathology Parkinson's disease Parkinsonian Disorders - drug therapy Parkinsonian Disorders - pathology Parkinsonian Disorders - physiopathology striatum substantia nigra Substantia Nigra - metabolism Substantia Nigra - pathology Substantia Nigra - physiopathology Tyrosine 3-Monooxygenase - metabolism tyrosine hydroxylase
ISSN:	0953-816X, 1460-9568
Online Access:	Get full text
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