Structural basis for substrate selectivity by site-one protease revealed by studies with a small-molecule inhibitor

Site-one protease (S1P) carries out the first proteolytic step to activate membrane-bound effector proteins in the Golgi. S1P matures through an autocatalytic process that begins in the endoplasmic reticulum (ER) and culminates with the displacement of its inhibitory pro-domain by its cofactor, ster...

Ausführliche Beschreibung