Oxysterols as markers of neurological disease - a review

Cholesterol plays a crucial structural role in the brain and local synthesis covers almost all the requirements of the brain. To maintain homeostasis, the excess of cholesterol is converted into the more hydrophilic oxysterol 24S-hydroxycholesterol by the neuron-specific enzyme CYP46A1. About 99 % o...

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Veröffentlicht in:	Scandinavian journal of clinical and laboratory investigation Jg. 69; H. 1; S. 22 - 25
1. Verfasser:	Leoni, Valerio
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Informa UK Ltd 01.01.2009 Taylor & Francis
Schlagworte:	24S-hydroxycholesterol 27-hydroxycholesterol Alzheimer disease Biomarkers - metabolism cerebrospinal fluid cholesterol gas chromatography mass spectrometry Humans Hydroxycholesterols multiple sclerosis Nervous System Diseases - diagnosis neurodegeneration
ISSN:	0036-5513, 1502-7686, 1502-7686
Online-Zugang:	Volltext
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