IL-5-producing CD4 + T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

Immune checkpoint blockade (ICB) has heralded a new era in cancer therapy. Research into the mechanisms underlying response to ICB has predominantly focused on T cells; however, effective immune responses require tightly regulated crosstalk between innate and adaptive immune cells. Here, we combine...

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Bibliographic Details
Published in:	Cancer cell Vol. 41; no. 1; p. 106
Main Authors:	Blomberg, Olga S, Spagnuolo, Lorenzo, Garner, Hannah, Voorwerk, Leonie, Isaeva, Olga I, van Dyk, Ewald, Bakker, Noor, Chalabi, Myriam, Klaver, Chris, Duijst, Maxime, Kersten, Kelly, Brüggemann, Marieke, Pastoors, Dorien, Hau, Cheei-Sing, Vrijland, Kim, Raeven, Elisabeth A M, Kaldenbach, Daphne, Kos, Kevin, Afonina, Inna S, Kaptein, Paulien, Hoes, Louisa, Theelen, Willemijn S M E, Baas, Paul, Voest, Emile E, Beyaert, Rudi, Thommen, Daniela S, Wessels, Lodewyk F A, de Visser, Karin E, Kok, Marleen
Format:	Journal Article
Language:	English
Published:	United States 09.01.2023
Subjects:	Animals Antigen Presentation CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes Eosinophils - pathology Immune Checkpoint Inhibitors - therapeutic use Interleukin-33 Interleukin-5 - therapeutic use Mice Neoplasms - drug therapy myeloid cells CD4(+) T cells IL-5 breast cancer eosinophils IL-33 immune checkpoint blockade
ISSN:	1878-3686, 1878-3686
Online Access:	Get more information
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