Fast track to personalized TCR T cell therapies
In this issue of Cancer Cell, Hanada et al. leverage single-cell multi-omics of lung cancer resident lymphocytes to identify phenotypic and transcriptomic signatures differentially expressed by neoantigen-reactive clonotypes. These findings could substantially expedite the selection of neoantigen-sp...
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| Published in: | Cancer cell Vol. 40; no. 5; p. 447 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
United States
09.05.2022
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| ISSN: | 1878-3686, 1878-3686 |
| Online Access: | Get more information |
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| Summary: | In this issue of Cancer Cell, Hanada et al. leverage single-cell multi-omics of lung cancer resident lymphocytes to identify phenotypic and transcriptomic signatures differentially expressed by neoantigen-reactive clonotypes. These findings could substantially expedite the selection of neoantigen-specific T cell receptors (TCRs) for individualized T cell therapies. |
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| Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Commentary-3 content type line 23 |
| ISSN: | 1878-3686 1878-3686 |
| DOI: | 10.1016/j.ccell.2022.04.013 |