Kidney Injury Molecule-1 (KIM-1): A specific and sensitive biomarker of kidney injury

There is an urgent need for the detection and monitoring of kidney injury in both the acute and chronic disease setting. Urinary kidney injury molecule-1 (Kim-1), a type-1 transmembrane protein, is not normally present, but is expressed on the proximal tubule apical membrane with injury. Kim-1 has p...

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Published in:Scandinavian journal of clinical & laboratory investigation. Supplement Vol. 68; no. S241; pp. 78 - 83
Main Author: Bonventre, Joseph V.
Format: Journal Article
Language:English
Published: Norway Informa UK Ltd 01.01.2008
Taylor & Francis
Subjects:
Animals
Biomarkers - urine
Hepatitis A Virus Cellular Receptor 1
histopathology
Humans
Kidney Diseases - diagnosis
Kidney Diseases - urine
Kidney Tubules, Proximal - pathology
Membrane Glycoproteins - chemistry
Membrane Glycoproteins - genetics
Membrane Glycoproteins - urine
proximal tubule
Receptors, Virus - chemistry
Receptors, Virus - genetics
RNA, Messenger - analysis
Sensitivity and Specificity
Transmembrane protein
ISSN:0036-5513, 0085-591X, 1502-7686
Online Access:Get full text
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Summary:There is an urgent need for the detection and monitoring of kidney injury in both the acute and chronic disease setting. Urinary kidney injury molecule-1 (Kim-1), a type-1 transmembrane protein, is not normally present, but is expressed on the proximal tubule apical membrane with injury. Kim-1 has proved to be an outstanding indicator of kidney injury in the rat, outperforming blood urea nitrogen and serum creatinine as predictors of histopathological changes in the proximal tubule in response to many pathophysiological states or toxicants. Studies in man indicate that tissue expression and urinary excretion of the ectodomain of KIM-1 are sensitive and specific markers of injury as well as predictors of outcome.
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ISSN:0036-5513
0085-591X
1502-7686
DOI:10.1080/00365510802145059