Inherent flexibility and protein function: The open/closed conformational transition in the N-terminal domain of calmodulin

The key to understand a protein's function often lies in its conformational dynamics. We develop a coarse-grained variational model to investigate the interplay between structural transitions, conformational flexibility, and function of the N-terminal calmodulin domain (nCaM). In this model, tw...

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Bibliographic Details

Published in:	The Journal of chemical physics Vol. 128; no. 20; p. 205104
Main Authors:	Tripathi, Swarnendu, Portman, John J
Format:	Journal Article
Language:	English
Published:	United States 28.05.2008
Subjects:	Binding Sites Calcium - metabolism Calmodulin - chemistry Calmodulin - metabolism Kinetics Methionine Microcomputers Models, Molecular Protein Folding Protein Structure, Secondary Protein Structure, Tertiary Thermodynamics Time Factors
ISSN:	1089-7690, 1089-7690
Online Access:	Get more information
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