Gender-dependent and age-of-onset-specific association of the rs11675434 single-nucleotide polymorphism near TPO with susceptibility to Graves’ ophthalmopathy

The role of TPO gene polymorphism in the susceptibility to Graves' disease (GD) remains unclear. However, single-nucleotide polymorphisms (SNPs) near TPO have been recently associated with serum levels of thyroid peroxidase (TPO) antibody in two independent genome-wide association studies. More...

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Veröffentlicht in:	Journal of human genetics Jg. 62; H. 3; S. 373 - 377
Hauptverfasser:	Kuś, Aleksander, Szymański, Konrad, Jurecka-Lubieniecka, Beata, Pawlak-Adamska, Edyta, Kula, Dorota, Miśkiewicz, Piotr, Bolanowski, Marek, Płoski, Rafał, Bossowski, Artur, Daroszewski, Jacek, Jarząb, Barbara, Bednarczuk, Tomasz
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.03.2017
Schlagworte:	Adolescent Adult Age Age of Onset Alleles Autoantibodies - blood Child Children Female Gender Gene Expression Gene Frequency Gene polymorphism Genetic Predisposition to Disease Genome-Wide Association Study Genomes Graves Ophthalmopathy - diagnosis Graves Ophthalmopathy - genetics Graves Ophthalmopathy - immunology Graves Ophthalmopathy - pathology Graves' disease Humans Iodide peroxidase Iodide Peroxidase - genetics Iodide Peroxidase - immunology Male Poland Polymorphism Polymorphism, Single Nucleotide Serum levels Sex differences Sex Factors Single-nucleotide polymorphism Thyroid
ISSN:	1434-5161, 1435-232X, 1435-232X
Online-Zugang:	Volltext
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