Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives

[Display omitted] •MET antidiabetic drug review was conducted.•The annual consumption of MET worldwide is in tons.•The occurrence of MET in the world ranges from ng L-1 to µg L-1.•MET toxic effects are embryotoxicity, teratogenicity and endocrine disruption.•Phytoremediation, adsorption and biodegra...

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Published in:The Science of the total environment Vol. 702; p. 134924
Main Authors: Elizalde-Velázquez, Gustavo Axel, Gómez-Oliván, Leobardo Manuel
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.02.2020
Subjects:
adsorption
animal ovaries
Antidiabetics
antineoplastic agents
aquatic environment
bioaccumulation
biodegradation
Biodegradation, Environmental
Consumption
effluents
Endocrine Disruptors - analysis
endocrine-disrupting chemicals
Environmental Monitoring
fish
food plants
food webs
humans
Hypoglycemic Agents - analysis
metabolism
Metformin
Metformin - analysis
mussels
noninsulin-dependent diabetes mellitus
Occurrence
phytoremediation
polycystic ovary syndrome
Removal
surface water
Toxicity
wastewater treatment
Water Pollutants, Chemical - analysis
Consumption
Removal
Metformin
Toxicity
Occurrence
Antidiabetics
ISSN:0048-9697, 1879-1026, 1879-1026
Online Access:Get full text
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Abstract [Display omitted] •MET antidiabetic drug review was conducted.•The annual consumption of MET worldwide is in tons.•The occurrence of MET in the world ranges from ng L-1 to µg L-1.•MET toxic effects are embryotoxicity, teratogenicity and endocrine disruption.•Phytoremediation, adsorption and biodegradation are used to remove MET. Metformin (MET) is the most common drug used to treat type 2 diabetes, but also it is used as an anticancer agent and as a treatment for polycystic ovary syndrome. This drug is not metabolized in the human body, and may enter into the environment through different pathways. In wastewater treatments plants (WWTPs), this contaminant is mainly transformed to guanylurea (GUA). However, three further transformation products (TPs): (a) 2,4- diamino-1,3,5-triazine, 4-DAT; (b) 2-amino-4-methylamino-1,3,5-triazine, 2,4-AMT; and (c) methylbiguanide, MBG; have also been associated with its metabolism. MET, GUA and MBG have been found in WWTPs influents, effluents and surface waters. Furthermore, MET and GUA bioaccumulate in edible plants species, fish and mussels potentially contaminating the human food web. MET is also a potential endocrine disruptor in fish. Phytoremediation, adsorption and biodegradation have shown a high removal efficiency of MET, in laboratory. Nonetheless, these removal methods had less efficiency when tried in WWTPs. Therefore, MET and its TPs are a threat to the human being as well as to our environment. This review comprehensively discuss the (1) pathways of MET to the environment and its life-cycle, (2) occurrence of MET and its transformation products (3) removal, (4) toxic effects and (5) future trends and perspectives of possible methods of elimination in water in order to provide potential options for managing these contaminants.
AbstractList Metformin (MET) is the most common drug used to treat type 2 diabetes, but also it is used as an anticancer agent and as a treatment for polycystic ovary syndrome. This drug is not metabolized in the human body, and may enter into the environment through different pathways. In wastewater treatments plants (WWTPs), this contaminant is mainly transformed to guanylurea (GUA). However, three further transformation products (TPs): (a) 2,4- diamino-1,3,5-triazine, 4-DAT; (b) 2-amino-4-methylamino-1,3,5-triazine, 2,4-AMT; and (c) methylbiguanide, MBG; have also been associated with its metabolism. MET, GUA and MBG have been found in WWTPs influents, effluents and surface waters. Furthermore, MET and GUA bioaccumulate in edible plants species, fish and mussels potentially contaminating the human food web. MET is also a potential endocrine disruptor in fish. Phytoremediation, adsorption and biodegradation have shown a high removal efficiency of MET, in laboratory. Nonetheless, these removal methods had less efficiency when tried in WWTPs. Therefore, MET and its TPs are a threat to the human being as well as to our environment. This review comprehensively discuss the (1) pathways of MET to the environment and its life-cycle, (2) occurrence of MET and its transformation products (3) removal, (4) toxic effects and (5) future trends and perspectives of possible methods of elimination in water in order to provide potential options for managing these contaminants.
Metformin (MET) is the most common drug used to treat type 2 diabetes, but also it is used as an anticancer agent and as a treatment for polycystic ovary syndrome. This drug is not metabolized in the human body, and may enter into the environment through different pathways. In wastewater treatments plants (WWTPs), this contaminant is mainly transformed to guanylurea (GUA). However, three further transformation products (TPs): (a) 2,4- diamino-1,3,5-triazine, 4-DAT; (b) 2-amino-4-methylamino-1,3,5-triazine, 2,4-AMT; and (c) methylbiguanide, MBG; have also been associated with its metabolism. MET, GUA and MBG have been found in WWTPs influents, effluents and surface waters. Furthermore, MET and GUA bioaccumulate in edible plants species, fish and mussels potentially contaminating the human food web. MET is also a potential endocrine disruptor in fish. Phytoremediation, adsorption and biodegradation have shown a high removal efficiency of MET, in laboratory. Nonetheless, these removal methods had less efficiency when tried in WWTPs. Therefore, MET and its TPs are a threat to the human being as well as to our environment. This review comprehensively discuss the (1) pathways of MET to the environment and its life-cycle, (2) occurrence of MET and its transformation products (3) removal, (4) toxic effects and (5) future trends and perspectives of possible methods of elimination in water in order to provide potential options for managing these contaminants.Metformin (MET) is the most common drug used to treat type 2 diabetes, but also it is used as an anticancer agent and as a treatment for polycystic ovary syndrome. This drug is not metabolized in the human body, and may enter into the environment through different pathways. In wastewater treatments plants (WWTPs), this contaminant is mainly transformed to guanylurea (GUA). However, three further transformation products (TPs): (a) 2,4- diamino-1,3,5-triazine, 4-DAT; (b) 2-amino-4-methylamino-1,3,5-triazine, 2,4-AMT; and (c) methylbiguanide, MBG; have also been associated with its metabolism. MET, GUA and MBG have been found in WWTPs influents, effluents and surface waters. Furthermore, MET and GUA bioaccumulate in edible plants species, fish and mussels potentially contaminating the human food web. MET is also a potential endocrine disruptor in fish. Phytoremediation, adsorption and biodegradation have shown a high removal efficiency of MET, in laboratory. Nonetheless, these removal methods had less efficiency when tried in WWTPs. Therefore, MET and its TPs are a threat to the human being as well as to our environment. This review comprehensively discuss the (1) pathways of MET to the environment and its life-cycle, (2) occurrence of MET and its transformation products (3) removal, (4) toxic effects and (5) future trends and perspectives of possible methods of elimination in water in order to provide potential options for managing these contaminants.
[Display omitted] •MET antidiabetic drug review was conducted.•The annual consumption of MET worldwide is in tons.•The occurrence of MET in the world ranges from ng L-1 to µg L-1.•MET toxic effects are embryotoxicity, teratogenicity and endocrine disruption.•Phytoremediation, adsorption and biodegradation are used to remove MET. Metformin (MET) is the most common drug used to treat type 2 diabetes, but also it is used as an anticancer agent and as a treatment for polycystic ovary syndrome. This drug is not metabolized in the human body, and may enter into the environment through different pathways. In wastewater treatments plants (WWTPs), this contaminant is mainly transformed to guanylurea (GUA). However, three further transformation products (TPs): (a) 2,4- diamino-1,3,5-triazine, 4-DAT; (b) 2-amino-4-methylamino-1,3,5-triazine, 2,4-AMT; and (c) methylbiguanide, MBG; have also been associated with its metabolism. MET, GUA and MBG have been found in WWTPs influents, effluents and surface waters. Furthermore, MET and GUA bioaccumulate in edible plants species, fish and mussels potentially contaminating the human food web. MET is also a potential endocrine disruptor in fish. Phytoremediation, adsorption and biodegradation have shown a high removal efficiency of MET, in laboratory. Nonetheless, these removal methods had less efficiency when tried in WWTPs. Therefore, MET and its TPs are a threat to the human being as well as to our environment. This review comprehensively discuss the (1) pathways of MET to the environment and its life-cycle, (2) occurrence of MET and its transformation products (3) removal, (4) toxic effects and (5) future trends and perspectives of possible methods of elimination in water in order to provide potential options for managing these contaminants.
ArticleNumber 134924
Author Gómez-Oliván, Leobardo Manuel
Elizalde-Velázquez, Gustavo Axel
Author_xml – sequence: 1
  givenname: Gustavo Axel
  surname: Elizalde-Velázquez
  fullname: Elizalde-Velázquez, Gustavo Axel
– sequence: 2
  givenname: Leobardo Manuel
  surname: Gómez-Oliván
  fullname: Gómez-Oliván, Leobardo Manuel
  email: lmgomezo@uaemex.mx, lgolivan74@gmail.com
BackLink https://www.ncbi.nlm.nih.gov/pubmed/31726346$$D View this record in MEDLINE/PubMed
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Cites_doi 10.2983/035.037.0301
10.1016/j.chemosphere.2015.03.060
10.1371/journal.pone.0207041
10.1016/j.jhazmat.2016.11.008
10.1371/journal.pone.0197259
10.1016/j.scitotenv.2018.02.105
10.1016/j.chemosphere.2017.03.071
10.1021/acs.est.7b00012
10.1007/s11356-018-3025-8
10.1016/j.scitotenv.2018.04.332
10.1016/j.chemosphere.2019.01.151
10.1016/j.aquatox.2017.01.012
10.1016/j.chemosphere.2015.04.078
10.1016/j.scitotenv.2016.07.118
10.1016/j.diabres.2018.05.023
10.1016/j.watres.2018.11.001
10.1016/j.jhazmat.2016.01.054
10.1016/j.envpol.2018.04.116
10.1007/s11356-015-5060-z
10.1097/FPC.0b013e3283559b22
10.1016/j.jpba.2017.08.014
10.3389/fenvs.2019.00045
10.1016/j.scitotenv.2016.03.063
10.1016/j.envpol.2016.01.088
10.1007/s10661-018-7097-1
10.1021/jf301267c
10.1007/s11356-016-6766-2
10.1146/annurev-med-062613-093128
10.1210/jc.2017-01739
10.1016/j.scitotenv.2019.01.072
10.1016/j.chemosphere.2015.12.022
10.1016/j.cmet.2014.09.018
10.1016/j.chemosphere.2017.02.095
10.22438/jeb/38/6(SI)/06
10.1002/jssc.201800507
10.1016/j.chemosphere.2016.08.084
10.1007/s11356-014-3400-z
10.1007/s10661-016-5637-0
10.1016/j.envpol.2017.10.032
10.1039/C8EW00278A
10.1016/j.jhazmat.2017.03.030
10.1016/j.envint.2014.05.008
10.1016/j.scitotenv.2018.04.179
10.1039/C8EM00390D
10.1016/j.chemosphere.2014.11.025
10.1016/j.envpol.2017.07.047
10.1016/j.chemosphere.2017.01.101
10.1016/j.aquatox.2017.06.011
10.1186/s12302-018-0179-4
10.1371/journal.pone.0182868
10.1016/j.envpol.2018.02.007
10.1016/j.arabjc.2012.11.014
10.1016/j.chemosphere.2018.02.106
10.1002/etc.4403
10.1016/j.diabres.2018.02.023
10.1007/s11356-017-9012-7
10.1016/j.scitotenv.2016.01.043
10.1016/j.jhazmat.2018.12.084
10.1016/j.aquatox.2018.10.003
10.1021/acs.estlett.6b00170
10.1002/etc.3873
10.1016/j.scitotenv.2015.02.104
10.1016/j.envpol.2018.08.075
10.1016/j.jece.2018.08.010
10.1016/j.ygcen.2015.12.030
10.1016/j.aquatox.2017.12.003
10.2166/wst.2016.001
10.1002/rcm.7724
10.1016/j.watres.2014.12.010
10.1007/s00216-015-8540-6
10.1016/j.chemosphere.2018.01.154
10.1016/j.apcatb.2014.04.001
10.1016/j.envpol.2018.09.031
10.23736/S0031-0808.18.03455-9
10.1002/etc.2793
10.1007/s13762-017-1538-1
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Keywords Consumption
Removal
Metformin
Toxicity
Occurrence
Antidiabetics
Language English
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References Chellappan, Yap, Gupta, Dua (b0080) 2018; 60
Cui, Schröder (b0100) 2016; 308
Koagouw, Ciocan (b0220) 2018; 37
MacLaren, Wisniewski, MacLaren (b0270) 2018; 13
Althakafy, Kulsing, Grace, Marriott (b0015) 2018; 41
Information Services Division National Services Scotland, 2018. Prescribing & Medicines: Dispenser Payments and Prescription Cost Analysis. NHS National Services Scotland, Scotland. Available at
Zhu, Liu, Liu, Zeng, Jiang, Tan, Yang (b0505) 2017; 179
Lee, Shin, Kim, Kim, Kim, Min, Park (b0250) 2019; 367
Kong, Kadokami, Wang, Duong, Chau (b0225) 2015; 122
Crago, Bui, Grewal, Schlenk (b0095) 2016; 232
Yeh, Marcinek, Meador, Gallagher (b0500) 2017; 190
Gordon (b0170) 2018
Prescribing and Medicines Team Health and Social Care Information Centre, 2018. Prescriptions Dispensed in the Community - Statistics for England, 2007–2017. Health and Social Care Information Centre, UK. Available at
Xing, Yu, Men (b0480) 2018; 4
Niemuth, Klaper (b0380) 2018; 195
Sundhedsdata-Styrelsen, 2018. Medstat.dk. Available at
Briones, Zhuang, Sarmah (b0060) 2018; 243
Johnson (b0205) 2018
Mayoudom, Nguidjoe, Mballa, Tankoua, Fokunang, Anyakora, Blackett (b0290) 2018; 190
Carmona, Andreu, Picó (b0070) 2017; 146
Moogouei, Borghei, Hosseini, Tajadod (b0335) 2018; 15
Tisler, Zwiener (b0445) 2018; 628
Tisler, Zwiener (b0450) 2019; 149
Elliott, Brigham, Lee, Banda, Choy, Gefell, Jorgenson (b0125) 2017; 12
Luja-Mondragón, Gómez-Oliván, SanJuan-Reyes, Islas-Flores, Orozco-Hernández, Heredia-García, Dublán-García (b0265) 2019; 660
Ussery, Bridges, Pandelides, Kirkwood, Bonetta, Venables, Holdway (b0465) 2018; 205
Archer, Petrie, Kasprzyk-Hordern, Wolfaardt (b0020) 2017; 174
Niemuth, Jordan, Crago, Blanksma, Johnson, Klaper (b0370) 2015; 34
Kleinrock (b0210) 2012
Pérez-Alvarez, Islas-Flores, Gómez-Oliván, Barceló, De Alda, Solsona, Galar-Martínez (b0395) 2018; 240
Foretz, Guigas, Bertrand, Pollak, Viollet (b0140) 2014; 20
Socialstyrelsen, 2018. Statistics Database for Drugs. Available at
Monshi (b0330) 2017
Melvin, Habener, Leusch, Carroll (b0315) 2017; 184
Cummings, Needoba, Peterson (b0105) 2018; 13
Morales, Morris (b0340) 2015; 66
Niemuth, Klaper (b0375) 2015; 135
Kosma, Lambropoulou, Albanis (b0235) 2015; 70
Kot-Wasik, Jakimska, Śliwka-Kaszyńska (b0240) 2016; 188
García-García, Reyes-Carrillo, Sarma, Nandini (b0150) 2017; 38
Moldovan, Marincas, Povar, Lupascu, Longree, Rota, Alder (b0325) 2018; 25
Posselt, Jaeger, Schaper, Radke, Benskin (b0400) 2018; 20
de Jesus Gaffney, Cardoso, Cardoso, Teixeira, Martins, Benoliel, Almeida (b0110) 2017; 24
Kong, Kadokami, Duong, Chau (b0230) 2016; 165
Ter Laak, Baken (b0435) 2014
Weissinger, Blackwell, Keteles, Battaglin, Bradley (b0475) 2018; 636
Jacob, Dötsch, Knoll, Köhler, Rogall, Stoll, Triebskorn (b0195) 2018; 30
Le Doujet (b0245) 2016
.
National Statistics Ystadegau Gwladol, 2018. Prescriptions dispensed in the community: 2017. Welsh Gov- ernment, Cardiff. Available at
Meador, Yeh, Young, Gallagher (b0295) 2016; 213
Estrada-Arriaga, Cortés-Muñoz, González-Herrera, Calderón-Mólgora, de Lourdes Rivera-Huerta, Ramírez-Camperos, Martín-Domínguez (b0135) 2016; 571
Meador, Yeh, Gallagher (b0300) 2017; 230
Bradley, Battaglin, Clark, Henning, Hladik, Iwanowicz, Romanok (b0045) 2017; 36
Bradley, Journey, Romanok, Barber, Buxton, Foreman, Jones (b0055) 2017; 51
Mohd Amin, Heijman, Rietveld (b0320) 2016; 73
Bai, Lutz, Carroll, Keteles, Dahlin, Murphy, Nguyen (b0035) 2018; 200
Huber, Remberger, Kaj, Schlabach, Jörundsdóttir, Vester, Dam (b0185) 2016; 562
Quintão, Freitas, de Fátima Machado, Aquino, de Queiroz Silva, de Cássia Franco Afonso (b0410) 2016; 30
Yan, Xiao, Tan, Shao, Zheng, Pei, Wang (b0485) 2019; 222
Chiarello, Minetto, Della Giustina, Beal, Moura (b0085) 2016; 23
Lee (b0255) 2017
Guzel, Cevik, Daglioglu (b0175) 2018
De Solla, Gilroy, Klinck, King, McInnis, Struger, Gillis (b0115) 2016; 146
Mulholland, A., 2018. Prescription Cost Analysis Northern Ireland 2017. Information and Registration Unit Family Practitioner Services Business Services Organization, Belfast. Available at
Gong, Goswami, Giacomini, Altman, Klein (b0165) 2012; 22
Orona-Návar, García-Morales, Rubio-Govea, Mahlknecht, Hernandez-Aranda, Ramírez, Ornelas-Soto (b0390) 2018; 6
Ghoshdastidar, Fox, Tong (b0155) 2015; 22
Bradley, Journey, Button, Carlisle, Clark, Mahler, VanMetre (b0050) 2016; 3
Markiewicz, Jungnickel, Stolte, Białk-Bielińska, Kumirska, Mrozik (b0285) 2017; 333
Yang, Hsu, Chen, Lai, Li, Chen, Ho (b0490) 2018; 103
Zorginstituut Nederland, 2018. GIP Database. Available at
Medical Expenditure Panel Survey (MEPS) (b0310) 2018; 19
Godoy, Domingues, Nogueira, Kummrow (b0160) 2018; 243
Eggen, Lillo (b0120) 2012; 60
Cho, Shaw, Karuranga, Huang, da Rocha Fernandes, Ohlrogge, Malanda (b0090) 2018; 138
Yao, Yan, Lian, Yang, Wan, Dong, Song (b0495) 2018; 236
Meador, Yeh, Gallagher (b0305) 2018; 236
Mallik, Chowdhury (b0275) 2018; 143
Gago-Ferrero, Borova, Dasenaki, Τhomaidis (b0145) 2015; 407
Aitken, Kleinrock, Lyle, Nass, Caskey (b0005) 2015
Blair, Nikolaus, Hedman, Klaper, Grundl (b0040) 2015; 134
Chau, Kadokami, Duong, Kong, Nguyen, Nguyen, Ito (b0075) 2018; 25
Nguyen (b0365) 2018
Asghar, Zhu, Sun, Shuai (b0025) 2018; 635
Lesser, Mora, Moreau, Mahlknecht, Hernández-Antonio, Ramírez, Barrios-Piña (b0260) 2018; 198
Markiewicz, Jungnickel, Stolte, Białk-Bielińska, Kumirska, Mrozik (b0280) 2017; 324
Shraim, Diab, Alsuhaimi, Niazy, Metwally, Amad, Dawoud (b0420) 2017; 10
Ali, Rønning, Alarif, Kallenborn, Al-Lihaibi (b0010) 2017; 175
Jacob, Köhler, Tisler, Zwiener, Triebskorn (b0200) 2019; 7
Oliveira, Murphy, Mendola, Wong, Carlson, Waring (b0385) 2015; 518
Thomaidi, Stasinakis, Borova, Thomaidis (b0440) 2016; 548
Trautwein, Berset, Wolschke, Kümmerer (b0455) 2014; 70
Neamţu, Grandjean, Sienkiewicz, Le Faucheur, Slaveykova, Colmenares, de Alencastro (b0360) 2014; 158
Ussery, Bridges, Pandelides, Kirkwood, Guchardi, Holdway (b0470) 2019; 38
Medical Expenditure Panel Survey (MEPS) (10.1016/j.scitotenv.2019.134924_b0310) 2018; 19
Mohd Amin (10.1016/j.scitotenv.2019.134924_b0320) 2016; 73
Neamţu (10.1016/j.scitotenv.2019.134924_b0360) 2014; 158
Foretz (10.1016/j.scitotenv.2019.134924_b0140) 2014; 20
Yang (10.1016/j.scitotenv.2019.134924_b0490) 2018; 103
Monshi (10.1016/j.scitotenv.2019.134924_b0330) 2017
Nguyen (10.1016/j.scitotenv.2019.134924_b0365) 2018
Niemuth (10.1016/j.scitotenv.2019.134924_b0370) 2015; 34
Orona-Návar (10.1016/j.scitotenv.2019.134924_b0390) 2018; 6
10.1016/j.scitotenv.2019.134924_b0405
Yao (10.1016/j.scitotenv.2019.134924_b0495) 2018; 236
García-García (10.1016/j.scitotenv.2019.134924_b0150) 2017; 38
Bradley (10.1016/j.scitotenv.2019.134924_b0045) 2017; 36
Bai (10.1016/j.scitotenv.2019.134924_b0035) 2018; 200
Gong (10.1016/j.scitotenv.2019.134924_b0165) 2012; 22
Lee (10.1016/j.scitotenv.2019.134924_b0250) 2019; 367
De Solla (10.1016/j.scitotenv.2019.134924_b0115) 2016; 146
Crago (10.1016/j.scitotenv.2019.134924_b0095) 2016; 232
Yeh (10.1016/j.scitotenv.2019.134924_b0500) 2017; 190
Aitken (10.1016/j.scitotenv.2019.134924_b0005) 2015
Lee (10.1016/j.scitotenv.2019.134924_b0255) 2017
Lesser (10.1016/j.scitotenv.2019.134924_b0260) 2018; 198
Chellappan (10.1016/j.scitotenv.2019.134924_b0080) 2018; 60
Jacob (10.1016/j.scitotenv.2019.134924_b0200) 2019; 7
Gordon (10.1016/j.scitotenv.2019.134924_b0170) 2018
Le Doujet (10.1016/j.scitotenv.2019.134924_b0245) 2016
Moogouei (10.1016/j.scitotenv.2019.134924_b0335) 2018; 15
Kleinrock (10.1016/j.scitotenv.2019.134924_b0210) 2012
Archer (10.1016/j.scitotenv.2019.134924_b0020) 2017; 174
Kong (10.1016/j.scitotenv.2019.134924_b0225) 2015; 122
Ghoshdastidar (10.1016/j.scitotenv.2019.134924_b0155) 2015; 22
Jacob (10.1016/j.scitotenv.2019.134924_b0195) 2018; 30
Zhu (10.1016/j.scitotenv.2019.134924_b0505) 2017; 179
Kong (10.1016/j.scitotenv.2019.134924_b0230) 2016; 165
Niemuth (10.1016/j.scitotenv.2019.134924_b0375) 2015; 135
Trautwein (10.1016/j.scitotenv.2019.134924_b0455) 2014; 70
Guzel (10.1016/j.scitotenv.2019.134924_b0175) 2018
Chiarello (10.1016/j.scitotenv.2019.134924_b0085) 2016; 23
Yan (10.1016/j.scitotenv.2019.134924_b0485) 2019; 222
Cho (10.1016/j.scitotenv.2019.134924_b0090) 2018; 138
Johnson (10.1016/j.scitotenv.2019.134924_b0205) 2018
Asghar (10.1016/j.scitotenv.2019.134924_b0025) 2018; 635
Meador (10.1016/j.scitotenv.2019.134924_b0305) 2018; 236
Kosma (10.1016/j.scitotenv.2019.134924_b0235) 2015; 70
Mayoudom (10.1016/j.scitotenv.2019.134924_b0290) 2018; 190
Elliott (10.1016/j.scitotenv.2019.134924_b0125) 2017; 12
Melvin (10.1016/j.scitotenv.2019.134924_b0315) 2017; 184
Niemuth (10.1016/j.scitotenv.2019.134924_b0380) 2018; 195
10.1016/j.scitotenv.2019.134924_b0425
Ter Laak (10.1016/j.scitotenv.2019.134924_b0435) 2014
Weissinger (10.1016/j.scitotenv.2019.134924_b0475) 2018; 636
de Jesus Gaffney (10.1016/j.scitotenv.2019.134924_b0110) 2017; 24
Thomaidi (10.1016/j.scitotenv.2019.134924_b0440) 2016; 548
Cummings (10.1016/j.scitotenv.2019.134924_b0105) 2018; 13
Moldovan (10.1016/j.scitotenv.2019.134924_b0325) 2018; 25
Carmona (10.1016/j.scitotenv.2019.134924_b0070) 2017; 146
Bradley (10.1016/j.scitotenv.2019.134924_b0050) 2016; 3
Briones (10.1016/j.scitotenv.2019.134924_b0060) 2018; 243
MacLaren (10.1016/j.scitotenv.2019.134924_b0270) 2018; 13
Koagouw (10.1016/j.scitotenv.2019.134924_b0220) 2018; 37
Markiewicz (10.1016/j.scitotenv.2019.134924_b0280) 2017; 324
Althakafy (10.1016/j.scitotenv.2019.134924_b0015) 2018; 41
Estrada-Arriaga (10.1016/j.scitotenv.2019.134924_b0135) 2016; 571
Eggen (10.1016/j.scitotenv.2019.134924_b0120) 2012; 60
Mallik (10.1016/j.scitotenv.2019.134924_b0275) 2018; 143
Cui (10.1016/j.scitotenv.2019.134924_b0100) 2016; 308
Quintão (10.1016/j.scitotenv.2019.134924_b0410) 2016; 30
Ussery (10.1016/j.scitotenv.2019.134924_b0465) 2018; 205
Chau (10.1016/j.scitotenv.2019.134924_b0075) 2018; 25
Blair (10.1016/j.scitotenv.2019.134924_b0040) 2015; 134
Bradley (10.1016/j.scitotenv.2019.134924_b0055) 2017; 51
Xing (10.1016/j.scitotenv.2019.134924_b0480) 2018; 4
Ali (10.1016/j.scitotenv.2019.134924_b0010) 2017; 175
Huber (10.1016/j.scitotenv.2019.134924_b0185) 2016; 562
Shraim (10.1016/j.scitotenv.2019.134924_b0420) 2017; 10
Meador (10.1016/j.scitotenv.2019.134924_b0300) 2017; 230
Godoy (10.1016/j.scitotenv.2019.134924_b0160) 2018; 243
Kot-Wasik (10.1016/j.scitotenv.2019.134924_b0240) 2016; 188
10.1016/j.scitotenv.2019.134924_b0350
10.1016/j.scitotenv.2019.134924_b0355
10.1016/j.scitotenv.2019.134924_b0510
Tisler (10.1016/j.scitotenv.2019.134924_b0445) 2018; 628
Luja-Mondragón (10.1016/j.scitotenv.2019.134924_b0265) 2019; 660
Pérez-Alvarez (10.1016/j.scitotenv.2019.134924_b0395) 2018; 240
10.1016/j.scitotenv.2019.134924_b0430
Tisler (10.1016/j.scitotenv.2019.134924_b0450) 2019; 149
10.1016/j.scitotenv.2019.134924_b0190
Markiewicz (10.1016/j.scitotenv.2019.134924_b0285) 2017; 333
Posselt (10.1016/j.scitotenv.2019.134924_b0400) 2018; 20
Meador (10.1016/j.scitotenv.2019.134924_b0295) 2016; 213
Oliveira (10.1016/j.scitotenv.2019.134924_b0385) 2015; 518
Gago-Ferrero (10.1016/j.scitotenv.2019.134924_b0145) 2015; 407
Ussery (10.1016/j.scitotenv.2019.134924_b0470) 2019; 38
Morales (10.1016/j.scitotenv.2019.134924_b0340) 2015; 66
References_xml – volume: 236
  start-page: 889
  year: 2018
  end-page: 898
  ident: b0495
  article-title: Occurrence and indicators of pharmaceuticals in Chinese streams: a nationwide study
  publication-title: Environ. Pollut.
– volume: 146
  start-page: 486
  year: 2016
  end-page: 496
  ident: b0115
  article-title: Bioaccumulation of pharmaceuticals and personal care products in the unionid mussel Lasmigona costata in a river receiving wastewater effluent
  publication-title: Chemosphere
– volume: 135
  start-page: 38
  year: 2015
  end-page: 45
  ident: b0375
  article-title: Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish
  publication-title: Chemosphere
– volume: 190
  start-page: 21
  year: 2017
  end-page: 31
  ident: b0500
  article-title: Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon
  publication-title: Aquat. Toxicol.
– volume: 41
  start-page: 3706
  year: 2018
  end-page: 3715
  ident: b0015
  article-title: Determination of selected emerging contaminants in freshwater invertebrates using a universal extraction technique and liquid chromatography accurate mass spectrometry
  publication-title: J. Sep. Sci.
– volume: 198
  start-page: 510
  year: 2018
  end-page: 521
  ident: b0260
  article-title: Survey of 218 organic contaminants in groundwater derived from the world's largest untreated wastewater irrigation system: Mezquital Valley, Mexico
  publication-title: Chemosphere
– volume: 38
  start-page: 1023
  year: 2019
  end-page: 1028
  ident: b0470
  article-title: Developmental and full-life cycle exposures to guanylurea, and guanylurea-metformin mixtures results in adverse effects on Japanese medaka (Oryzias latipes)
  publication-title: Environ. Toxicol. Chem.
– volume: 571
  start-page: 1172
  year: 2016
  end-page: 1182
  ident: b0135
  article-title: Assessment of full-scale biological nutrient removal systems upgraded with physico-chemical processes for the removal of emerging pollutants present in wastewaters from Mexico
  publication-title: Sci. Total Environ.
– volume: 175
  start-page: 505
  year: 2017
  end-page: 513
  ident: b0010
  article-title: Occurrence of pharmaceuticals and personal care products in effluent-dominated Saudi Arabian coastal waters of the Red Sea
  publication-title: Chemosphere
– volume: 548
  start-page: 280
  year: 2016
  end-page: 288
  ident: b0440
  article-title: Assessing the risk associated with the presence of emerging organic contaminants in sludge-amended soil: a country-level analysis
  publication-title: Sci. Total Environ.
– volume: 36
  start-page: 3045
  year: 2017
  end-page: 3056
  ident: b0045
  article-title: Widespread occurrence and potential for biodegradation of bioactive contaminants in Congaree National Park, USA
  publication-title: Environ. Toxicol. Chem.
– volume: 13
  year: 2018
  ident: b0270
  article-title: Environmental concentrations of metformin exposure affect aggressive behavior in the Siamese fighting fish, Betta splendens
  publication-title: PloS One
– volume: 213
  start-page: 254
  year: 2016
  end-page: 267
  ident: b0295
  article-title: Contaminants of emerging concern in a large temperate estuary
  publication-title: Environ. Pollut.
– volume: 15
  start-page: 593
  year: 2018
  end-page: 598
  ident: b0335
  article-title: Potential of plant species for phytoremediation of metformin from solutions
  publication-title: Int. J. Environ. Sci. Technol.
– volume: 122
  start-page: 125
  year: 2015
  end-page: 130
  ident: b0225
  article-title: Monitoring of 1300 organic micro-pollutants in surface waters from Tianjin, North China
  publication-title: Chemosphere
– volume: 190
  start-page: 723
  year: 2018
  ident: b0290
  article-title: Identification and quantification of 19 pharmaceutical active compounds and metabolites in hospital wastewater in Cameroon using LC/QQQ and LC/Q-TOF
  publication-title: Environ. Monit. Assess.
– volume: 243
  start-page: 534
  year: 2018
  end-page: 542
  ident: b0160
  article-title: Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin
  publication-title: Environ. Pollut.
– volume: 562
  start-page: 13
  year: 2016
  end-page: 25
  ident: b0185
  article-title: A first screening and risk assessment of pharmaceuticals and additives in personal care products in waste water, sludge, recipient water and sediment from Faroe Islands, Iceland and Greenland
  publication-title: Sci. Total Environ.
– volume: 158
  start-page: 30
  year: 2014
  end-page: 37
  ident: b0360
  article-title: Degradation of eight relevant micropollutants in different water matrices by neutral photo-Fenton process under UV254 and simulated solar light irradiation–a comparative study
  publication-title: Appl. Catal. B
– reference: Sundhedsdata-Styrelsen, 2018. Medstat.dk. Available at:
– volume: 230
  start-page: 1018
  year: 2017
  end-page: 1029
  ident: b0300
  article-title: Determining potential adverse effects in marine fish exposed to pharmaceuticals and personal care products with the fish plasma model and whole-body tissue concentrations
  publication-title: Environ. Pollut.
– volume: 236
  start-page: 850
  year: 2018
  end-page: 861
  ident: b0305
  article-title: Adverse metabolic effects in fish exposed to contaminants of emerging concern in the field and laboratory
  publication-title: Environ. Pollut.
– volume: 19
  start-page: 1
  year: 2018
  ident: b0310
  article-title: Agency for healthcare research and quality (AHRQ), Rockville, MD
  publication-title: ClinCalc DrugStats Database version
– volume: 34
  start-page: 291
  year: 2015
  end-page: 296
  ident: b0370
  article-title: Metformin exposure at environmentally relevant concentrations causes potential endocrine disruption in adult male fish
  publication-title: Environ. Toxicol. Chem.
– volume: 205
  start-page: 58
  year: 2018
  end-page: 65
  ident: b0465
  article-title: Effects of environmentally relevant metformin exposure on Japanese medaka (Oryzias latipes)
  publication-title: Aquat. Toxicol.
– volume: 25
  start-page: 7147
  year: 2018
  end-page: 7156
  ident: b0075
  article-title: Occurrence of 1153 organic micropollutants in the aquatic environment of Vietnam
  publication-title: Environ. Sci. Pollut. Res.
– year: 2016
  ident: b0245
  article-title: Uptake, Organ Distribution and Physiological Effects of an Anti-diabetic II Drug (Metformin) in Atlantic Salmon (Salmo salar)
– year: 2014
  ident: b0435
  article-title: The Occurrence, Fate and Ecological and Human Health Risks of Metformin and Guanylurea in the Water Cycle–A Literature Review
– volume: 179
  start-page: 20
  year: 2017
  end-page: 28
  ident: b0505
  article-title: Adsorption of emerging contaminant metformin using graphene oxide
  publication-title: Chemosphere
– volume: 23
  start-page: 16079
  year: 2016
  end-page: 16089
  ident: b0085
  article-title: Popular pharmaceutical residues in hospital wastewater: quantification and qualification of degradation products by mass spectroscopy after treatment with membrane bioreactor
  publication-title: Environ. Sci. Pollut. Res.
– start-page: 1
  year: 2018
  end-page: 16
  ident: b0175
  article-title: Determination of pharmaceutical active compounds in Ceyhan River, Turkey: seasonal, spatial variations and environmental risk assessment
  publication-title: Human Ecol. Risk Assess.: Int. J.
– volume: 518
  start-page: 459
  year: 2015
  end-page: 478
  ident: b0385
  article-title: Characterization of pharmaceuticals and personal care products in hospital effluent and waste water influent/effluent by direct-injection LC-MS-MS
  publication-title: Sci. Total Environ.
– volume: 10
  start-page: S719
  year: 2017
  end-page: S729
  ident: b0420
  article-title: Analysis of some pharmaceuticals in municipal wastewater of Almadinah Almunawarah
  publication-title: Arabian J. Chem.
– volume: 22
  start-page: 689
  year: 2015
  end-page: 700
  ident: b0155
  article-title: The presence of the top prescribed pharmaceuticals in treated sewage effluents and receiving waters in Southwest Nova Scotia, Canada
  publication-title: Environ. Sci. Pollut. Res.
– start-page: 36
  year: 2018
  ident: b0205
  article-title: The effects of acute urban mixture exposure on the t cells of fathead minnows (Pimephales promelas)
  publication-title: Culminating Projects Biol.
– volume: 6
  start-page: 5332
  year: 2018
  end-page: 5340
  ident: b0390
  article-title: Adsorptive removal of emerging pollutants from groundwater by using modified titanate nanotubes
  publication-title: J. Environ. Chem. Eng.
– volume: 20
  start-page: 953
  year: 2014
  end-page: 966
  ident: b0140
  article-title: Metformin: from mechanisms of action to therapies
  publication-title: Cell Metab.
– year: 2018
  ident: b0365
  article-title: Analysis of Emerging Environmental Contaminations using Advanced Instrumental Tools: Application to Human and Environmental Exposure
– reference: Information Services Division National Services Scotland, 2018. Prescribing & Medicines: Dispenser Payments and Prescription Cost Analysis. NHS National Services Scotland, Scotland. Available at:
– volume: 51
  start-page: 4792
  year: 2017
  end-page: 4802
  ident: b0055
  article-title: Expanded target-chemical analysis reveals extensive mixed-organic-contaminant exposure in US streams
  publication-title: Environ. Sci. Technol.
– volume: 143
  start-page: 409
  year: 2018
  end-page: 419
  ident: b0275
  article-title: Metformin in cancer
  publication-title: Diabetes Res. Clin. Pract.
– volume: 195
  start-page: 33
  year: 2018
  end-page: 40
  ident: b0380
  article-title: Low-dose metformin exposure causes changes in expression of endocrine disruption-associated genes
  publication-title: Aquat. Toxicol.
– year: 2012
  ident: b0210
  article-title: The use of medicines in the united states: review of 2011
– volume: 66
  start-page: 17
  year: 2015
  end-page: 29
  ident: b0340
  article-title: Metformin in cancer treatment and prevention
  publication-title: Annu. Rev. Med.
– volume: 134
  start-page: 395
  year: 2015
  end-page: 401
  ident: b0040
  article-title: Evaluating the degradation, sorption, and negative mass balances of pharmaceuticals and personal care products during wastewater treatment
  publication-title: Chemosphere
– volume: 22
  start-page: 820
  year: 2012
  ident: b0165
  article-title: Metformin pathways: pharmacokinetics and pharmacodynamics
  publication-title: Pharmacogenet. Genomics
– volume: 3
  start-page: 243
  year: 2016
  end-page: 249
  ident: b0050
  article-title: Metformin and other pharmaceuticals widespread in wadeable streams of the southeastern United States
  publication-title: Environ. Sci. Technol. Lett.
– volume: 628
  start-page: 1121
  year: 2018
  end-page: 1129
  ident: b0445
  article-title: Formation and occurrence of transformation products of metformin in wastewater and surface water
  publication-title: Sci. Total Environ.
– volume: 660
  start-page: 751
  year: 2019
  end-page: 764
  ident: b0265
  article-title: Alterations to embryonic development and teratogenic effects induced by a hospital effluent on Cyprinus carpio oocytes
  publication-title: Sci. Total Environ.
– volume: 13
  year: 2018
  ident: b0105
  article-title: Effect of metformin exposure on growth and photosynthetic performance in the unicellular freshwater chlorophyte, Chlorella vulgaris
  publication-title: PloS one
– volume: 174
  start-page: 437
  year: 2017
  end-page: 446
  ident: b0020
  article-title: The fate of pharmaceuticals and personal care products (PPCPs), endocrine disrupting contaminants (EDCs), metabolites and illicit drugs in a WWTW and environmental waters
  publication-title: Chemosphere
– volume: 60
  start-page: 6929
  year: 2012
  end-page: 6935
  ident: b0120
  article-title: Antidiabetic II drug metformin in plants: uptake and translocation to edible parts of cereals, oily seeds, beans, tomato, squash, carrots, and potatoes
  publication-title: J. Agric. Food. Chem.
– volume: 25
  start-page: 31040
  year: 2018
  end-page: 31050
  ident: b0325
  article-title: Environmental exposure of anthropogenic micropollutants in the Prut River at the Romanian-Moldavian border: a snapshot in the lower Danube river basin
  publication-title: Environ. Sci. Pollut. Res.
– volume: 165
  start-page: 221
  year: 2016
  end-page: 230
  ident: b0230
  article-title: Screening of 1300 organic micro-pollutants in groundwater from Beijing and Tianjin, North China
  publication-title: Chemosphere
– volume: 243
  start-page: 255
  year: 2018
  end-page: 262
  ident: b0060
  article-title: Biodegradation of metformin and guanylurea by aerobic cultures enriched from sludge
  publication-title: Environ. Pollut.
– volume: 24
  start-page: 14717
  year: 2017
  end-page: 14734
  ident: b0110
  article-title: Occurrence and behaviour of pharmaceutical compounds in a Portuguese wastewater treatment plant: removal efficiency through conventional treatment processes
  publication-title: Environ. Sci. Pollut. Res.
– volume: 7
  start-page: 45
  year: 2019
  ident: b0200
  article-title: Impact of the antidiabetic drug metformin and its transformation product guanylurea on the health of the big ramshorn snail (Planorbarius corneus)
  publication-title: Front. Environ. Sci.
– volume: 70
  start-page: 203
  year: 2014
  end-page: 212
  ident: b0455
  article-title: Occurrence of the antidiabetic drug Metformin and its ultimate transformation product Guanylurea in several compartments of the aquatic cycle
  publication-title: Environ. Int.
– year: 2015
  ident: b0005
  article-title: Medicines Use and Spending Shifts: A Review of the Use of Medicines in the US in 2014
– volume: 308
  start-page: 355
  year: 2016
  end-page: 361
  ident: b0100
  article-title: Uptake, translocation and possible biodegradation of the antidiabetic agent metformin by hydroponically grown Typha latifolia
  publication-title: J. Hazard. Mater.
– volume: 407
  start-page: 4287
  year: 2015
  end-page: 4297
  ident: b0145
  article-title: Simultaneous determination of 148 pharmaceuticals and illicit drugs in sewage sludge based on ultrasound-assisted extraction and liquid chromatography–tandem mass spectrometry
  publication-title: Anal. Bioanal. Chem.
– volume: 70
  start-page: 436
  year: 2015
  end-page: 448
  ident: b0235
  article-title: Comprehensive study of the antidiabetic drug metformin and its transformation product guanylurea in Greek wastewaters
  publication-title: Water Res.
– volume: 73
  start-page: 1719
  year: 2016
  end-page: 1727
  ident: b0320
  article-title: Clay–starch combination for micropollutants removal from wastewater treatment plant effluent
  publication-title: Water Sci. Technol.
– volume: 12
  year: 2017
  ident: b0125
  article-title: Contaminants of emerging concern in tributaries to the Laurentian Great Lakes: I. Patterns of occurrence
  publication-title: PloS One
– start-page: 37
  year: 2018
  ident: b0170
  article-title: The effects of urban contaminants on neutrophils of fathead minnows (Pimephales promelas)
  publication-title: Culminating Projects Biol.
– volume: 37
  start-page: 467
  year: 2018
  end-page: 475
  ident: b0220
  article-title: Impact of metformin and increased temperature on blue mussels Mytilus edulis-evidence for synergism
  publication-title: J. Shellfish Res.
– volume: 367
  start-page: 171
  year: 2019
  end-page: 181
  ident: b0250
  article-title: Metformin-induced endocrine disruption and oxidative stress of Oryzias latipes on two-generational condition
  publication-title: J. Hazard. Mater.
– volume: 188
  start-page: 661
  year: 2016
  ident: b0240
  article-title: Occurrence and seasonal variations of 25 pharmaceutical residues in wastewater and drinking water treatment plants
  publication-title: Environ. Monit. Assess.
– volume: 146
  start-page: 117
  year: 2017
  end-page: 125
  ident: b0070
  article-title: Multi-residue determination of 47 organic compounds in water, soil, sediment and fish—Turia River as case study
  publication-title: J. Pharm. Biomed. Anal.
– volume: 636
  start-page: 910
  year: 2018
  end-page: 918
  ident: b0475
  article-title: Bioactive contaminants of emerging concern in National Park waters of the northern Colorado Plateau, USA
  publication-title: Sci. Total Environ.
– volume: 184
  start-page: 123
  year: 2017
  end-page: 132
  ident: b0315
  article-title: 1H NMR-based metabolomics reveals sub-lethal toxicity of a mixture of diabetic and lipid-regulating pharmaceuticals on amphibian larvae
  publication-title: Aquat. Toxicol.
– volume: 635
  start-page: 828
  year: 2018
  end-page: 837
  ident: b0025
  article-title: Suspect screening and target quantification of human pharmaceutical residues in the surface wat°er of Wuhan, China, using UHPLC-Q-Orbitrap HRMS
  publication-title: Sci. Total Environ.
– volume: 200
  start-page: 133
  year: 2018
  end-page: 142
  ident: b0035
  article-title: Occurrence, distribution, and seasonality of emerging contaminants in urban watersheds
  publication-title: Chemosphere
– volume: 4
  start-page: 1412
  year: 2018
  end-page: 1426
  ident: b0480
  article-title: Emerging investigators series: Occurrence and fate of emerging organic contaminants in wastewater treatment plants with an enhanced nitrification step
  publication-title: Environ. Sci. Water Res. Technol.
– volume: 60
  start-page: 117
  year: 2018
  end-page: 131
  ident: b0080
  article-title: Current therapies and targets for type 2 diabetes mellitus
  publication-title: Panminerva Med.
– volume: 38
  start-page: 1213
  year: 2017
  end-page: 1219
  ident: b0150
  article-title: Population level responses of rotifers (Brachionus calyciflorus and Plationus patulus) to the anti-diabetic drug, metformin
  publication-title: J. Environ. Biol.
– start-page: 578
  year: 2017
  ident: b0330
  article-title: Endocrine-Disrupting Properties Of Pharmaceuticals And Personal Care Products (ppcps): An Evaluation Using Aquatic Model Organisms
– volume: 30
  start-page: 2360
  year: 2016
  end-page: 2368
  ident: b0410
  article-title: Characterization of metformin by‐products under photolysis, photocatalysis, ozonation and chlorination by high‐performance liquid chromatography coupled to high‐resolution mass spectrometry
  publication-title: Rapid Commun. Mass Spectr.
– reference: Mulholland, A., 2018. Prescription Cost Analysis Northern Ireland 2017. Information and Registration Unit Family Practitioner Services Business Services Organization, Belfast. Available at:
– volume: 30
  start-page: 48
  year: 2018
  ident: b0195
  article-title: Does the antidiabetic drug metformin affect embryo development and the health of brown trout (Salmo trutta f. fario)?
  publication-title: Environ. Sci. Europe
– volume: 20
  start-page: 1716
  year: 2018
  end-page: 1727
  ident: b0400
  article-title: Determination of polar organic micropollutants in surface and pore water by high-resolution sampling-direct injection-ultra high performance liquid chromatography-tandem mass spectrometry
  publication-title: Environ. Sci. Processes Impacts
– volume: 333
  start-page: 154
  year: 2017
  end-page: 161
  ident: b0285
  article-title: Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs
  publication-title: J. Hazard. Mater.
– volume: 103
  start-page: 890
  year: 2018
  end-page: 899
  ident: b0490
  article-title: The efficacy of 24-month metformin for improving menses, hormones, and metabolic profiles in polycystic ovary syndrome
  publication-title: J. Clin. Endocrinol. Metab.
– volume: 138
  start-page: 271
  year: 2018
  end-page: 281
  ident: b0090
  article-title: IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045
  publication-title: Diabetes Res. Clin. Pract.
– year: 2017
  ident: b0255
  article-title: Assessment of Aquatic Toxicity and Endocrine Disruption Potential of Metformin, an Anti-diabetic Drug
– reference: .
– reference: Socialstyrelsen, 2018. Statistics Database for Drugs. Available at:
– reference: Prescribing and Medicines Team Health and Social Care Information Centre, 2018. Prescriptions Dispensed in the Community - Statistics for England, 2007–2017. Health and Social Care Information Centre, UK. Available at:
– volume: 222
  start-page: 688
  year: 2019
  end-page: 695
  ident: b0485
  article-title: Wastewater analysis reveals spatial pattern in consumption of anti-diabetes drug metformin in China
  publication-title: Chemosphere
– volume: 232
  start-page: 185
  year: 2016
  end-page: 190
  ident: b0095
  article-title: Age-dependent effects in fathead minnows from the anti-diabetic drug metformin
  publication-title: Gen. Comp. Endocrinol.
– reference: Zorginstituut Nederland, 2018. GIP Database. Available at:
– volume: 324
  start-page: 428
  year: 2017
  end-page: 435
  ident: b0280
  article-title: Primary degradation of antidiabetic drugs
  publication-title: J. Hazard. Mater.
– volume: 240
  start-page: 330
  year: 2018
  end-page: 341
  ident: b0395
  article-title: Determination of metals and pharmaceutical compounds released in hospital wastewater from Toluca, Mexico, and evaluation of their toxic impact
  publication-title: Environ. Pollut.
– reference: National Statistics Ystadegau Gwladol, 2018. Prescriptions dispensed in the community: 2017. Welsh Gov- ernment, Cardiff. Available at:
– volume: 149
  start-page: 130
  year: 2019
  end-page: 135
  ident: b0450
  article-title: Aerobic and anaerobic formation and biodegradation of guanylurea and other transformation products of metformin
  publication-title: Water Res.
– volume: 37
  start-page: 467
  issue: 3
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0220
  article-title: Impact of metformin and increased temperature on blue mussels Mytilus edulis-evidence for synergism
  publication-title: J. Shellfish Res.
  doi: 10.2983/035.037.0301
– ident: 10.1016/j.scitotenv.2019.134924_b0355
– volume: 135
  start-page: 38
  year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0375
  article-title: Emerging wastewater contaminant metformin causes intersex and reduced fecundity in fish
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2015.03.060
– volume: 13
  issue: 11
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0105
  article-title: Effect of metformin exposure on growth and photosynthetic performance in the unicellular freshwater chlorophyte, Chlorella vulgaris
  publication-title: PloS one
  doi: 10.1371/journal.pone.0207041
– volume: 324
  start-page: 428
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0280
  article-title: Primary degradation of antidiabetic drugs
  publication-title: J. Hazard. Mater.
  doi: 10.1016/j.jhazmat.2016.11.008
– volume: 13
  issue: 5
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0270
  article-title: Environmental concentrations of metformin exposure affect aggressive behavior in the Siamese fighting fish, Betta splendens
  publication-title: PloS One
  doi: 10.1371/journal.pone.0197259
– volume: 628
  start-page: 1121
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0445
  article-title: Formation and occurrence of transformation products of metformin in wastewater and surface water
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2018.02.105
– volume: 179
  start-page: 20
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0505
  article-title: Adsorption of emerging contaminant metformin using graphene oxide
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2017.03.071
– ident: 10.1016/j.scitotenv.2019.134924_b0425
– volume: 51
  start-page: 4792
  issue: 9
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0055
  article-title: Expanded target-chemical analysis reveals extensive mixed-organic-contaminant exposure in US streams
  publication-title: Environ. Sci. Technol.
  doi: 10.1021/acs.est.7b00012
– volume: 25
  start-page: 31040
  issue: 31
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0325
  article-title: Environmental exposure of anthropogenic micropollutants in the Prut River at the Romanian-Moldavian border: a snapshot in the lower Danube river basin
  publication-title: Environ. Sci. Pollut. Res.
  doi: 10.1007/s11356-018-3025-8
– volume: 636
  start-page: 910
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0475
  article-title: Bioactive contaminants of emerging concern in National Park waters of the northern Colorado Plateau, USA
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2018.04.332
– volume: 222
  start-page: 688
  year: 2019
  ident: 10.1016/j.scitotenv.2019.134924_b0485
  article-title: Wastewater analysis reveals spatial pattern in consumption of anti-diabetes drug metformin in China
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2019.01.151
– volume: 184
  start-page: 123
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0315
  article-title: 1H NMR-based metabolomics reveals sub-lethal toxicity of a mixture of diabetic and lipid-regulating pharmaceuticals on amphibian larvae
  publication-title: Aquat. Toxicol.
  doi: 10.1016/j.aquatox.2017.01.012
– volume: 134
  start-page: 395
  year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0040
  article-title: Evaluating the degradation, sorption, and negative mass balances of pharmaceuticals and personal care products during wastewater treatment
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2015.04.078
– volume: 571
  start-page: 1172
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0135
  article-title: Assessment of full-scale biological nutrient removal systems upgraded with physico-chemical processes for the removal of emerging pollutants present in wastewaters from Mexico
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2016.07.118
– volume: 143
  start-page: 409
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0275
  article-title: Metformin in cancer
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2018.05.023
– volume: 149
  start-page: 130
  year: 2019
  ident: 10.1016/j.scitotenv.2019.134924_b0450
  article-title: Aerobic and anaerobic formation and biodegradation of guanylurea and other transformation products of metformin
  publication-title: Water Res.
  doi: 10.1016/j.watres.2018.11.001
– volume: 308
  start-page: 355
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0100
  article-title: Uptake, translocation and possible biodegradation of the antidiabetic agent metformin by hydroponically grown Typha latifolia
  publication-title: J. Hazard. Mater.
  doi: 10.1016/j.jhazmat.2016.01.054
– year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0245
– ident: 10.1016/j.scitotenv.2019.134924_b0190
– volume: 240
  start-page: 330
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0395
  article-title: Determination of metals and pharmaceutical compounds released in hospital wastewater from Toluca, Mexico, and evaluation of their toxic impact
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2018.04.116
– year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0255
– volume: 25
  start-page: 7147
  issue: 8
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0075
  article-title: Occurrence of 1153 organic micropollutants in the aquatic environment of Vietnam
  publication-title: Environ. Sci. Pollut. Res.
  doi: 10.1007/s11356-015-5060-z
– volume: 22
  start-page: 820
  issue: 11
  year: 2012
  ident: 10.1016/j.scitotenv.2019.134924_b0165
  article-title: Metformin pathways: pharmacokinetics and pharmacodynamics
  publication-title: Pharmacogenet. Genomics
  doi: 10.1097/FPC.0b013e3283559b22
– volume: 146
  start-page: 117
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0070
  article-title: Multi-residue determination of 47 organic compounds in water, soil, sediment and fish—Turia River as case study
  publication-title: J. Pharm. Biomed. Anal.
  doi: 10.1016/j.jpba.2017.08.014
– volume: 7
  start-page: 45
  year: 2019
  ident: 10.1016/j.scitotenv.2019.134924_b0200
  article-title: Impact of the antidiabetic drug metformin and its transformation product guanylurea on the health of the big ramshorn snail (Planorbarius corneus)
  publication-title: Front. Environ. Sci.
  doi: 10.3389/fenvs.2019.00045
– volume: 562
  start-page: 13
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0185
  article-title: A first screening and risk assessment of pharmaceuticals and additives in personal care products in waste water, sludge, recipient water and sediment from Faroe Islands, Iceland and Greenland
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2016.03.063
– volume: 213
  start-page: 254
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0295
  article-title: Contaminants of emerging concern in a large temperate estuary
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2016.01.088
– volume: 190
  start-page: 723
  issue: 12
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0290
  article-title: Identification and quantification of 19 pharmaceutical active compounds and metabolites in hospital wastewater in Cameroon using LC/QQQ and LC/Q-TOF
  publication-title: Environ. Monit. Assess.
  doi: 10.1007/s10661-018-7097-1
– volume: 60
  start-page: 6929
  issue: 28
  year: 2012
  ident: 10.1016/j.scitotenv.2019.134924_b0120
  article-title: Antidiabetic II drug metformin in plants: uptake and translocation to edible parts of cereals, oily seeds, beans, tomato, squash, carrots, and potatoes
  publication-title: J. Agric. Food. Chem.
  doi: 10.1021/jf301267c
– volume: 23
  start-page: 16079
  issue: 16
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0085
  article-title: Popular pharmaceutical residues in hospital wastewater: quantification and qualification of degradation products by mass spectroscopy after treatment with membrane bioreactor
  publication-title: Environ. Sci. Pollut. Res.
  doi: 10.1007/s11356-016-6766-2
– year: 2012
  ident: 10.1016/j.scitotenv.2019.134924_b0210
– volume: 66
  start-page: 17
  year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0340
  article-title: Metformin in cancer treatment and prevention
  publication-title: Annu. Rev. Med.
  doi: 10.1146/annurev-med-062613-093128
– volume: 103
  start-page: 890
  issue: 3
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0490
  article-title: The efficacy of 24-month metformin for improving menses, hormones, and metabolic profiles in polycystic ovary syndrome
  publication-title: J. Clin. Endocrinol. Metab.
  doi: 10.1210/jc.2017-01739
– volume: 660
  start-page: 751
  year: 2019
  ident: 10.1016/j.scitotenv.2019.134924_b0265
  article-title: Alterations to embryonic development and teratogenic effects induced by a hospital effluent on Cyprinus carpio oocytes
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2019.01.072
– volume: 146
  start-page: 486
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0115
  article-title: Bioaccumulation of pharmaceuticals and personal care products in the unionid mussel Lasmigona costata in a river receiving wastewater effluent
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2015.12.022
– volume: 20
  start-page: 953
  issue: 6
  year: 2014
  ident: 10.1016/j.scitotenv.2019.134924_b0140
  article-title: Metformin: from mechanisms of action to therapies
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2014.09.018
– volume: 175
  start-page: 505
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0010
  article-title: Occurrence of pharmaceuticals and personal care products in effluent-dominated Saudi Arabian coastal waters of the Red Sea
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2017.02.095
– volume: 38
  start-page: 1213
  issue: 6
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0150
  article-title: Population level responses of rotifers (Brachionus calyciflorus and Plationus patulus) to the anti-diabetic drug, metformin
  publication-title: J. Environ. Biol.
  doi: 10.22438/jeb/38/6(SI)/06
– volume: 41
  start-page: 3706
  issue: 19
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0015
  article-title: Determination of selected emerging contaminants in freshwater invertebrates using a universal extraction technique and liquid chromatography accurate mass spectrometry
  publication-title: J. Sep. Sci.
  doi: 10.1002/jssc.201800507
– volume: 165
  start-page: 221
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0230
  article-title: Screening of 1300 organic micro-pollutants in groundwater from Beijing and Tianjin, North China
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2016.08.084
– volume: 22
  start-page: 689
  issue: 1
  year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0155
  article-title: The presence of the top prescribed pharmaceuticals in treated sewage effluents and receiving waters in Southwest Nova Scotia, Canada
  publication-title: Environ. Sci. Pollut. Res.
  doi: 10.1007/s11356-014-3400-z
– volume: 188
  start-page: 661
  issue: 12
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0240
  article-title: Occurrence and seasonal variations of 25 pharmaceutical residues in wastewater and drinking water treatment plants
  publication-title: Environ. Monit. Assess.
  doi: 10.1007/s10661-016-5637-0
– volume: 236
  start-page: 889
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0495
  article-title: Occurrence and indicators of pharmaceuticals in Chinese streams: a nationwide study
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2017.10.032
– volume: 4
  start-page: 1412
  issue: 10
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0480
  article-title: Emerging investigators series: Occurrence and fate of emerging organic contaminants in wastewater treatment plants with an enhanced nitrification step
  publication-title: Environ. Sci. Water Res. Technol.
  doi: 10.1039/C8EW00278A
– start-page: 578
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0330
– volume: 333
  start-page: 154
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0285
  article-title: Ultimate biodegradability and ecotoxicity of orally administered antidiabetic drugs
  publication-title: J. Hazard. Mater.
  doi: 10.1016/j.jhazmat.2017.03.030
– volume: 70
  start-page: 203
  year: 2014
  ident: 10.1016/j.scitotenv.2019.134924_b0455
  article-title: Occurrence of the antidiabetic drug Metformin and its ultimate transformation product Guanylurea in several compartments of the aquatic cycle
  publication-title: Environ. Int.
  doi: 10.1016/j.envint.2014.05.008
– volume: 635
  start-page: 828
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0025
  article-title: Suspect screening and target quantification of human pharmaceutical residues in the surface wat°er of Wuhan, China, using UHPLC-Q-Orbitrap HRMS
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2018.04.179
– volume: 20
  start-page: 1716
  issue: 12
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0400
  article-title: Determination of polar organic micropollutants in surface and pore water by high-resolution sampling-direct injection-ultra high performance liquid chromatography-tandem mass spectrometry
  publication-title: Environ. Sci. Processes Impacts
  doi: 10.1039/C8EM00390D
– volume: 122
  start-page: 125
  year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0225
  article-title: Monitoring of 1300 organic micro-pollutants in surface waters from Tianjin, North China
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2014.11.025
– start-page: 36
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0205
  article-title: The effects of acute urban mixture exposure on the t cells of fathead minnows (Pimephales promelas)
  publication-title: Culminating Projects Biol.
– volume: 230
  start-page: 1018
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0300
  article-title: Determining potential adverse effects in marine fish exposed to pharmaceuticals and personal care products with the fish plasma model and whole-body tissue concentrations
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2017.07.047
– volume: 174
  start-page: 437
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0020
  article-title: The fate of pharmaceuticals and personal care products (PPCPs), endocrine disrupting contaminants (EDCs), metabolites and illicit drugs in a WWTW and environmental waters
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2017.01.101
– year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0365
– volume: 19
  start-page: 1
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0310
  article-title: Agency for healthcare research and quality (AHRQ), Rockville, MD
  publication-title: ClinCalc DrugStats Database version
– volume: 190
  start-page: 21
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0500
  article-title: Effect of contaminants of emerging concern on liver mitochondrial function in Chinook salmon
  publication-title: Aquat. Toxicol.
  doi: 10.1016/j.aquatox.2017.06.011
– year: 2014
  ident: 10.1016/j.scitotenv.2019.134924_b0435
– volume: 30
  start-page: 48
  issue: 1
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0195
  article-title: Does the antidiabetic drug metformin affect embryo development and the health of brown trout (Salmo trutta f. fario)?
  publication-title: Environ. Sci. Europe
  doi: 10.1186/s12302-018-0179-4
– ident: 10.1016/j.scitotenv.2019.134924_b0430
– volume: 12
  issue: 9
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0125
  article-title: Contaminants of emerging concern in tributaries to the Laurentian Great Lakes: I. Patterns of occurrence
  publication-title: PloS One
  doi: 10.1371/journal.pone.0182868
– ident: 10.1016/j.scitotenv.2019.134924_b0350
– volume: 236
  start-page: 850
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0305
  article-title: Adverse metabolic effects in fish exposed to contaminants of emerging concern in the field and laboratory
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2018.02.007
– volume: 10
  start-page: S719
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0420
  article-title: Analysis of some pharmaceuticals in municipal wastewater of Almadinah Almunawarah
  publication-title: Arabian J. Chem.
  doi: 10.1016/j.arabjc.2012.11.014
– volume: 200
  start-page: 133
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0035
  article-title: Occurrence, distribution, and seasonality of emerging contaminants in urban watersheds
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2018.02.106
– volume: 38
  start-page: 1023
  issue: 5
  year: 2019
  ident: 10.1016/j.scitotenv.2019.134924_b0470
  article-title: Developmental and full-life cycle exposures to guanylurea, and guanylurea-metformin mixtures results in adverse effects on Japanese medaka (Oryzias latipes)
  publication-title: Environ. Toxicol. Chem.
  doi: 10.1002/etc.4403
– volume: 138
  start-page: 271
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0090
  article-title: IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045
  publication-title: Diabetes Res. Clin. Pract.
  doi: 10.1016/j.diabres.2018.02.023
– start-page: 1
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0175
  article-title: Determination of pharmaceutical active compounds in Ceyhan River, Turkey: seasonal, spatial variations and environmental risk assessment
  publication-title: Human Ecol. Risk Assess.: Int. J.
– volume: 24
  start-page: 14717
  issue: 17
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0110
  article-title: Occurrence and behaviour of pharmaceutical compounds in a Portuguese wastewater treatment plant: removal efficiency through conventional treatment processes
  publication-title: Environ. Sci. Pollut. Res.
  doi: 10.1007/s11356-017-9012-7
– volume: 548
  start-page: 280
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0440
  article-title: Assessing the risk associated with the presence of emerging organic contaminants in sludge-amended soil: a country-level analysis
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2016.01.043
– volume: 367
  start-page: 171
  year: 2019
  ident: 10.1016/j.scitotenv.2019.134924_b0250
  article-title: Metformin-induced endocrine disruption and oxidative stress of Oryzias latipes on two-generational condition
  publication-title: J. Hazard. Mater.
  doi: 10.1016/j.jhazmat.2018.12.084
– volume: 205
  start-page: 58
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0465
  article-title: Effects of environmentally relevant metformin exposure on Japanese medaka (Oryzias latipes)
  publication-title: Aquat. Toxicol.
  doi: 10.1016/j.aquatox.2018.10.003
– volume: 3
  start-page: 243
  issue: 6
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0050
  article-title: Metformin and other pharmaceuticals widespread in wadeable streams of the southeastern United States
  publication-title: Environ. Sci. Technol. Lett.
  doi: 10.1021/acs.estlett.6b00170
– volume: 36
  start-page: 3045
  issue: 11
  year: 2017
  ident: 10.1016/j.scitotenv.2019.134924_b0045
  article-title: Widespread occurrence and potential for biodegradation of bioactive contaminants in Congaree National Park, USA
  publication-title: Environ. Toxicol. Chem.
  doi: 10.1002/etc.3873
– volume: 518
  start-page: 459
  year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0385
  article-title: Characterization of pharmaceuticals and personal care products in hospital effluent and waste water influent/effluent by direct-injection LC-MS-MS
  publication-title: Sci. Total Environ.
  doi: 10.1016/j.scitotenv.2015.02.104
– volume: 243
  start-page: 255
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0060
  article-title: Biodegradation of metformin and guanylurea by aerobic cultures enriched from sludge
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2018.08.075
– volume: 6
  start-page: 5332
  issue: 4
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0390
  article-title: Adsorptive removal of emerging pollutants from groundwater by using modified titanate nanotubes
  publication-title: J. Environ. Chem. Eng.
  doi: 10.1016/j.jece.2018.08.010
– year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0005
– volume: 232
  start-page: 185
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0095
  article-title: Age-dependent effects in fathead minnows from the anti-diabetic drug metformin
  publication-title: Gen. Comp. Endocrinol.
  doi: 10.1016/j.ygcen.2015.12.030
– ident: 10.1016/j.scitotenv.2019.134924_b0510
– volume: 195
  start-page: 33
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0380
  article-title: Low-dose metformin exposure causes changes in expression of endocrine disruption-associated genes
  publication-title: Aquat. Toxicol.
  doi: 10.1016/j.aquatox.2017.12.003
– volume: 73
  start-page: 1719
  issue: 7
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0320
  article-title: Clay–starch combination for micropollutants removal from wastewater treatment plant effluent
  publication-title: Water Sci. Technol.
  doi: 10.2166/wst.2016.001
– ident: 10.1016/j.scitotenv.2019.134924_b0405
– volume: 30
  start-page: 2360
  issue: 21
  year: 2016
  ident: 10.1016/j.scitotenv.2019.134924_b0410
  article-title: Characterization of metformin by‐products under photolysis, photocatalysis, ozonation and chlorination by high‐performance liquid chromatography coupled to high‐resolution mass spectrometry
  publication-title: Rapid Commun. Mass Spectr.
  doi: 10.1002/rcm.7724
– start-page: 37
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0170
  article-title: The effects of urban contaminants on neutrophils of fathead minnows (Pimephales promelas)
  publication-title: Culminating Projects Biol.
– volume: 70
  start-page: 436
  year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0235
  article-title: Comprehensive study of the antidiabetic drug metformin and its transformation product guanylurea in Greek wastewaters
  publication-title: Water Res.
  doi: 10.1016/j.watres.2014.12.010
– volume: 407
  start-page: 4287
  issue: 15
  year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0145
  article-title: Simultaneous determination of 148 pharmaceuticals and illicit drugs in sewage sludge based on ultrasound-assisted extraction and liquid chromatography–tandem mass spectrometry
  publication-title: Anal. Bioanal. Chem.
  doi: 10.1007/s00216-015-8540-6
– volume: 198
  start-page: 510
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0260
  article-title: Survey of 218 organic contaminants in groundwater derived from the world's largest untreated wastewater irrigation system: Mezquital Valley, Mexico
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2018.01.154
– volume: 158
  start-page: 30
  year: 2014
  ident: 10.1016/j.scitotenv.2019.134924_b0360
  article-title: Degradation of eight relevant micropollutants in different water matrices by neutral photo-Fenton process under UV254 and simulated solar light irradiation–a comparative study
  publication-title: Appl. Catal. B
  doi: 10.1016/j.apcatb.2014.04.001
– volume: 243
  start-page: 534
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0160
  article-title: Ecotoxicological effects, water quality standards and risk assessment for the anti-diabetic metformin
  publication-title: Environ. Pollut.
  doi: 10.1016/j.envpol.2018.09.031
– volume: 60
  start-page: 117
  issue: 3
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0080
  article-title: Current therapies and targets for type 2 diabetes mellitus
  publication-title: Panminerva Med.
  doi: 10.23736/S0031-0808.18.03455-9
– volume: 34
  start-page: 291
  issue: 2
  year: 2015
  ident: 10.1016/j.scitotenv.2019.134924_b0370
  article-title: Metformin exposure at environmentally relevant concentrations causes potential endocrine disruption in adult male fish
  publication-title: Environ. Toxicol. Chem.
  doi: 10.1002/etc.2793
– volume: 15
  start-page: 593
  issue: 3
  year: 2018
  ident: 10.1016/j.scitotenv.2019.134924_b0335
  article-title: Potential of plant species for phytoremediation of metformin from solutions
  publication-title: Int. J. Environ. Sci. Technol.
  doi: 10.1007/s13762-017-1538-1
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Snippet [Display omitted] •MET antidiabetic drug review was conducted.•The annual consumption of MET worldwide is in tons.•The occurrence of MET in the world ranges...
Metformin (MET) is the most common drug used to treat type 2 diabetes, but also it is used as an anticancer agent and as a treatment for polycystic ovary...
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SubjectTerms adsorption
animal ovaries
Antidiabetics
antineoplastic agents
aquatic environment
bioaccumulation
biodegradation
Biodegradation, Environmental
Consumption
effluents
Endocrine Disruptors - analysis
endocrine-disrupting chemicals
Environmental Monitoring
fish
food plants
food webs
humans
Hypoglycemic Agents - analysis
metabolism
Metformin
Metformin - analysis
mussels
noninsulin-dependent diabetes mellitus
Occurrence
phytoremediation
polycystic ovary syndrome
Removal
surface water
Toxicity
wastewater treatment
Water Pollutants, Chemical - analysis
Title Occurrence, toxic effects and removal of metformin in the aquatic environments in the world: Recent trends and perspectives
URI https://dx.doi.org/10.1016/j.scitotenv.2019.134924
https://www.ncbi.nlm.nih.gov/pubmed/31726346
https://www.proquest.com/docview/2315088700
https://www.proquest.com/docview/2388759917
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