The JAMM motif of human deubiquitinase Poh1 is essential for cell viability

Poh1 deubiquitinase activity is required for proteolytic processing of polyubiquitinated substrates by the 26S proteasome, linking deubiquitination to complete substrate degradation. Poh1 RNA interference (RNAi) in HeLa cells resulted in a reduction in cell viability and an increase in polyubiquitin...

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Veröffentlicht in:	Molecular cancer therapeutics Jg. 6; H. 1; S. 262
Hauptverfasser:	Gallery, Melissa, Blank, Jonathan L, Lin, Yinghui, Gutierrez, Juan A, Pulido, Jacqueline C, Rappoli, David, Badola, Sunita, Rolfe, Mark, Macbeth, Kyle J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.01.2007
Schlagworte:	Amino Acid Motifs Cell Survival HeLa Cells Humans Mutant Proteins - metabolism Proteasome Endopeptidase Complex - chemistry Proteasome Endopeptidase Complex - deficiency Proteasome Endopeptidase Complex - metabolism RNA Interference Trans-Activators - chemistry Trans-Activators - deficiency Trans-Activators - metabolism Ubiquitin - metabolism
ISSN:	1535-7163
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