RNF168 Promotes Noncanonical K27 Ubiquitination to Signal DNA Damage

Ubiquitination regulates numerous cellular processes by generating a versatile communication system based on eight structurally and functionally different chains linked through distinct residues. Except for K48 and K63, the biological relevance of different linkages is largely unclear. Here, we show...

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Veröffentlicht in:	Cell reports (Cambridge) Jg. 10; H. 2; S. 226 - 238
Hauptverfasser:	Gatti, Marco, Pinato, Sabrina, Maiolica, Alessio, Rocchio, Francesca, Prato, Maria Giulia, Aebersold, Ruedi, Penengo, Lorenza
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 13.01.2015 Elsevier
Schlagworte:	Amino Acid Sequence BRCA1 Protein - metabolism Cell Line, Tumor Chromatin - metabolism DNA Damage DNA Repair HEK293 Cells Histones - chemistry Histones - metabolism Humans Intracellular Signaling Peptides and Proteins - metabolism Molecular Sequence Data RNA Interference RNA, Small Interfering - metabolism Tumor Suppressor p53-Binding Protein 1 Ubiquitin - antagonists & inhibitors Ubiquitin - genetics Ubiquitin - metabolism Ubiquitin-Conjugating Enzymes - metabolism Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
ISSN:	2211-1247, 2211-1247
Online-Zugang:	Volltext
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