Neutrophils create a fertile soil for metastasis

Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellul...

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Vydáno v:Cancer cell Ročník 39; číslo 3; s. 301
Hlavní autoři: Kos, Kevin, de Visser, Karin E
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 08.03.2021
ISSN:1878-3686, 1878-3686
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Abstract Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellular traps in the metastatic niche, thereby promoting lung metastasis.
AbstractList Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellular traps in the metastatic niche, thereby promoting lung metastasis.
Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellular traps in the metastatic niche, thereby promoting lung metastasis.Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellular traps in the metastatic niche, thereby promoting lung metastasis.
Author Kos, Kevin
de Visser, Karin E
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  organization: Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands
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  givenname: Karin E
  surname: de Visser
  fullname: de Visser, Karin E
  email: k.d.visser@nki.nl
  organization: Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: k.d.visser@nki.nl
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