Modulating the complement system through epitope-specific inhibition by complement C3 inhibitors

As an integral part of the innate immune system, the complement system is a tightly regulated proteolytic cascade, playing a critical role in microbial defense, inflammation activation, and dying host cell clearance. Complement proteins are now emerging as subjects of intense research and drug devel...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 301; no. 3; p. 108250
Main Authors:	Chen, Zhidong, Wang, Mingshuang, Duan, Wenqian, Xia, Yi, Liu, Huiqin, Qian, Feng
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.03.2025 American Society for Biochemistry and Molecular Biology
Subjects:	Complement Activation - drug effects complement C3 Complement C3 - antagonists & inhibitors Complement C3 - chemistry Complement C3 - immunology Complement C3 - metabolism Complement Inactivating Agents - chemistry Complement Inactivating Agents - pharmacology complement system epitope-specific targeting Epitopes - chemistry Epitopes - immunology Humans process-specific bioassay Structure-Activity Relationship structure-activity relationship (SAR) FH FI LP complement system complement C3 shRBCs PNH PDI SPR MIs MD NHS GA SEC-HPLC process-specific bioassay cryo-EM epitope-specific targeting rRBCs CX-MS MS RMSD CP MAC AP structure-activity relationship (SAR) wAMD ITC FB FD ELISA
ISSN:	0021-9258, 1083-351X, 1083-351X
Online Access:	Get full text
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