Lymphocyte networks are dynamic cellular communities in the immunoregulatory landscape of lung adenocarcinoma

Lymphocytes are key for immune surveillance of tumors, but our understanding of the spatial organization and physical interactions that facilitate lymphocyte anti-cancer functions is limited. We used multiplexed imaging, quantitative spatial analysis, and machine learning to create high-definition m...

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Bibliographic Details
Published in:	Cancer cell Vol. 41; no. 5; p. 871
Main Authors:	Gaglia, Giorgio, Burger, Megan L, Ritch, Cecily C, Rammos, Danae, Dai, Yang, Crossland, Grace E, Tavana, Sara Z, Warchol, Simon, Jaeger, Alex M, Naranjo, Santiago, Coy, Shannon, Nirmal, Ajit J, Krueger, Robert, Lin, Jia-Ren, Pfister, Hanspeter, Sorger, Peter K, Jacks, Tyler, Santagata, Sandro
Format:	Journal Article
Language:	English
Published:	United States 08.05.2023
Subjects:	Adenocarcinoma of Lung - genetics Animals CD8-Positive T-Lymphocytes Humans Immunity Immunotherapy - methods Lung Neoplasms - pathology Mice computational biology spatial biology systems biology CyCIF multimodal data integration cancer vaccines spatial profiling immunotherapy lung adenocarcinoma multiplexed imaging
ISSN:	1878-3686, 1878-3686
Online Access:	Get more information
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