Extremely asymmetric ectasia: Tomographically unilateral keratoconus

Purpose To investigate the characteristics of apparently stable forms of tomographically unilateral keratoconus (KC). Methods In this retrospective case–control study, strict unilaterality criteria were applied to select tomographically unilateral cases with ≥3 years of follow‐up. For comparison, a...

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Vydáno v:Acta ophthalmologica (Oxford, England) Ročník 103; číslo 5; s. 530 - 538
Hlavní autoři: Shabani, Hasan, Ramdas, Wishal D., Meester‐Smoor, Magda A., Rizopoulos, Dimitris, Klaver, Caroline C. W., Dooren, Bart T. H., Geerards, Annette J. M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Wiley Subscription Services, Inc 01.08.2025
John Wiley and Sons Inc
Témata:
Adult
Case-Control Studies
Cornea - pathology
Corneal Pachymetry
Corneal Topography - methods
Dilatation, Pathologic - diagnosis
Eczema
Female
Follow-Up Studies
forme fruste keratoconus
Humans
Keratoconus
Keratoconus - diagnosis
keratoconus aetiology
keratoconus epidemiology
keratoconus risk factors
Male
Middle Aged
Original
Population studies
Retrospective Studies
Risk Factors
Scheimpflug tomography
Statistical analysis
unilateral keratoconus
very asymmetric ectasia
Visual Acuity
Young Adult
keratoconus aetiology
Scheimpflug tomography
keratoconus
very asymmetric ectasia
keratoconus epidemiology
unilateral keratoconus
keratoconus risk factors
forme fruste keratoconus
ISSN:1755-375X, 1755-3768, 1755-3768
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Shrnutí:Purpose To investigate the characteristics of apparently stable forms of tomographically unilateral keratoconus (KC). Methods In this retrospective case–control study, strict unilaterality criteria were applied to select tomographically unilateral cases with ≥3 years of follow‐up. For comparison, a healthy cohort and two bilateral KC cohorts were matched to the tomographically unilateral cases. All patients were selected from The Rotterdam Eye Hospital, whereas healthy controls were selected from the population‐based Rotterdam Study. After cohort selection, several risk factors and 25 Pentacam features were assessed. Unaffected (i.e. tomographically non‐keratoconic) eyes from the tomographically unilateral cases were compared to matched healthy eyes, matched bilateral KC eyes and affected unilateral KC eyes. Furthermore, affected tomographically unilateral KC eyes were compared to matched bilateral KC eyes. Statistical analysis relied on Wilcoxon signed‐rank tests and conditional logistic regression. Results From 1006 assessed cases, 18 (1.8%) tomographically unilateral cases were selected. Their median (interquartile range) follow‐up was 5.7 (4.3–8) years. Eczema and asthma were more prevalent among tomographically unilateral patients (28% each) compared to bilateral patients (6% and 9%) (p = 0.01 and p = 0.05, signed‐rank test). We could not detect meaningful Pentacam differences between unaffected unilateral eyes and matched healthy eyes. Expectedly, significant differences were detected between unaffected unilateral eyes and affected (bilateral or unilateral) eyes. Lastly, the ectatic features of affected unilateral eyes seemed comparable to their bilateral counterparts, but their high‐order aberrations were significantly lower. Conclusion Our findings support the existence of tomographically unilateral KC. Understanding how tomographic unilaterality ensues may offer valuable insights into KC aetiology.
Bibliografie:ObjectType-Article-1
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ISSN:1755-375X
1755-3768
1755-3768
DOI:10.1111/aos.17456