A meta‐analysis of perfusion parameters affecting weight gain in ex vivo perfusion
Background Ex vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize that there is a significant relationship between specific parameters during EVMP and perfusion outcomes. Methods A meta‐analysis of literatur...
Uložené v:
| Vydané v: | Artificial organs Ročník 49; číslo 1; s. 7 - 20 |
|---|---|
| Hlavní autori: | , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
United States
Wiley Subscription Services, Inc
01.01.2025
John Wiley and Sons Inc |
| Predmet: | |
| ISSN: | 0160-564X, 1525-1594, 1525-1594 |
| On-line prístup: | Získať plný text |
| Tagy: |
Pridať tag
Žiadne tagy, Buďte prvý, kto otaguje tento záznam!
|
| Abstract | Background
Ex vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize that there is a significant relationship between specific parameters during EVMP and perfusion outcomes.
Methods
A meta‐analysis of literature was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) Statement. The search encompassed articles published before July 25, 2023. PubMed, Embase, and CENTRAL databases were screened using search terms “ex‐vivo,” “ex‐situ,” “machine,” and “perfusion.” Weight gain, an indicator of organ viability, was chosen to compare outcomes. Extracted variables included perfused organ, warm and cold ischemia time before perfusion, perfusion duration, perfusate flow, pressure, temperature, perfusate composition (presence of cellular or acellular oxygen carrier, colloids, and other supplements) and percent weight change. Data were analyzed using SPSS statistical software.
Results
Overall, 44 articles were included. Red blood cell‐based perfusates resulted in significantly lower weight gain compared to acellular perfusates without oxygen carriers (11.3% vs. 27.0%, p < 0.001). Hemoglobin‐based oxygen carriers resulted in significantly lower weight gain compared to acellular perfusates (16.5% vs. 27%, p = 0.006). Normothermic perfusion led to the least weight gain (14.6%), significantly different from hypothermic (24.3%) and subnormothermic (25.0%) conditions (p < 0.001), with no significant difference between hypothermic and subnormothermic groups (24.3% vs. 25.0%, p = 0.952). There was a positive correlation between flow rate and weight gain (ß = 13.1, R = 0.390, p < 0.001).
Conclusions
Oxygen carriers, low flow rates, and normothermic perfusate temperature appear to improve outcomes in EVMP. These findings offer opportunities for improving organ transplantation outcomes.
Oxygen carriers, lower flow rates, and normothermic perfusate temperature appear to improve outcomes in ex vivo machine perfusion. |
|---|---|
| AbstractList | Ex vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize that there is a significant relationship between specific parameters during EVMP and perfusion outcomes.BACKGROUNDEx vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize that there is a significant relationship between specific parameters during EVMP and perfusion outcomes.A meta-analysis of literature was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement. The search encompassed articles published before July 25, 2023. PubMed, Embase, and CENTRAL databases were screened using search terms "ex-vivo," "ex-situ," "machine," and "perfusion." Weight gain, an indicator of organ viability, was chosen to compare outcomes. Extracted variables included perfused organ, warm and cold ischemia time before perfusion, perfusion duration, perfusate flow, pressure, temperature, perfusate composition (presence of cellular or acellular oxygen carrier, colloids, and other supplements) and percent weight change. Data were analyzed using SPSS statistical software.METHODSA meta-analysis of literature was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement. The search encompassed articles published before July 25, 2023. PubMed, Embase, and CENTRAL databases were screened using search terms "ex-vivo," "ex-situ," "machine," and "perfusion." Weight gain, an indicator of organ viability, was chosen to compare outcomes. Extracted variables included perfused organ, warm and cold ischemia time before perfusion, perfusion duration, perfusate flow, pressure, temperature, perfusate composition (presence of cellular or acellular oxygen carrier, colloids, and other supplements) and percent weight change. Data were analyzed using SPSS statistical software.Overall, 44 articles were included. Red blood cell-based perfusates resulted in significantly lower weight gain compared to acellular perfusates without oxygen carriers (11.3% vs. 27.0%, p < 0.001). Hemoglobin-based oxygen carriers resulted in significantly lower weight gain compared to acellular perfusates (16.5% vs. 27%, p = 0.006). Normothermic perfusion led to the least weight gain (14.6%), significantly different from hypothermic (24.3%) and subnormothermic (25.0%) conditions (p < 0.001), with no significant difference between hypothermic and subnormothermic groups (24.3% vs. 25.0%, p = 0.952). There was a positive correlation between flow rate and weight gain (ß = 13.1, R = 0.390, p < 0.001).RESULTSOverall, 44 articles were included. Red blood cell-based perfusates resulted in significantly lower weight gain compared to acellular perfusates without oxygen carriers (11.3% vs. 27.0%, p < 0.001). Hemoglobin-based oxygen carriers resulted in significantly lower weight gain compared to acellular perfusates (16.5% vs. 27%, p = 0.006). Normothermic perfusion led to the least weight gain (14.6%), significantly different from hypothermic (24.3%) and subnormothermic (25.0%) conditions (p < 0.001), with no significant difference between hypothermic and subnormothermic groups (24.3% vs. 25.0%, p = 0.952). There was a positive correlation between flow rate and weight gain (ß = 13.1, R = 0.390, p < 0.001).Oxygen carriers, low flow rates, and normothermic perfusate temperature appear to improve outcomes in EVMP. These findings offer opportunities for improving organ transplantation outcomes.CONCLUSIONSOxygen carriers, low flow rates, and normothermic perfusate temperature appear to improve outcomes in EVMP. These findings offer opportunities for improving organ transplantation outcomes. Background Ex vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize that there is a significant relationship between specific parameters during EVMP and perfusion outcomes. Methods A meta‐analysis of literature was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) Statement. The search encompassed articles published before July 25, 2023. PubMed, Embase, and CENTRAL databases were screened using search terms “ex‐vivo,” “ex‐situ,” “machine,” and “perfusion.” Weight gain, an indicator of organ viability, was chosen to compare outcomes. Extracted variables included perfused organ, warm and cold ischemia time before perfusion, perfusion duration, perfusate flow, pressure, temperature, perfusate composition (presence of cellular or acellular oxygen carrier, colloids, and other supplements) and percent weight change. Data were analyzed using SPSS statistical software. Results Overall, 44 articles were included. Red blood cell‐based perfusates resulted in significantly lower weight gain compared to acellular perfusates without oxygen carriers (11.3% vs. 27.0%, p < 0.001). Hemoglobin‐based oxygen carriers resulted in significantly lower weight gain compared to acellular perfusates (16.5% vs. 27%, p = 0.006). Normothermic perfusion led to the least weight gain (14.6%), significantly different from hypothermic (24.3%) and subnormothermic (25.0%) conditions (p < 0.001), with no significant difference between hypothermic and subnormothermic groups (24.3% vs. 25.0%, p = 0.952). There was a positive correlation between flow rate and weight gain (ß = 13.1, R = 0.390, p < 0.001). Conclusions Oxygen carriers, low flow rates, and normothermic perfusate temperature appear to improve outcomes in EVMP. These findings offer opportunities for improving organ transplantation outcomes. Oxygen carriers, lower flow rates, and normothermic perfusate temperature appear to improve outcomes in ex vivo machine perfusion. Background Ex vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize that there is a significant relationship between specific parameters during EVMP and perfusion outcomes. Methods A meta‐analysis of literature was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta‐Analysis (PRISMA) Statement. The search encompassed articles published before July 25, 2023. PubMed, Embase, and CENTRAL databases were screened using search terms “ex‐vivo,” “ex‐situ,” “machine,” and “perfusion.” Weight gain, an indicator of organ viability, was chosen to compare outcomes. Extracted variables included perfused organ, warm and cold ischemia time before perfusion, perfusion duration, perfusate flow, pressure, temperature, perfusate composition (presence of cellular or acellular oxygen carrier, colloids, and other supplements) and percent weight change. Data were analyzed using SPSS statistical software. Results Overall, 44 articles were included. Red blood cell‐based perfusates resulted in significantly lower weight gain compared to acellular perfusates without oxygen carriers (11.3% vs. 27.0%, p < 0.001). Hemoglobin‐based oxygen carriers resulted in significantly lower weight gain compared to acellular perfusates (16.5% vs. 27%, p = 0.006). Normothermic perfusion led to the least weight gain (14.6%), significantly different from hypothermic (24.3%) and subnormothermic (25.0%) conditions (p < 0.001), with no significant difference between hypothermic and subnormothermic groups (24.3% vs. 25.0%, p = 0.952). There was a positive correlation between flow rate and weight gain (ß = 13.1, R = 0.390, p < 0.001). Conclusions Oxygen carriers, low flow rates, and normothermic perfusate temperature appear to improve outcomes in EVMP. These findings offer opportunities for improving organ transplantation outcomes. Oxygen carriers, lower flow rates, and normothermic perfusate temperature appear to improve outcomes in ex vivo machine perfusion. Ex vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize that there is a significant relationship between specific parameters during EVMP and perfusion outcomes. A meta-analysis of literature was conducted in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) Statement. The search encompassed articles published before July 25, 2023. PubMed, Embase, and CENTRAL databases were screened using search terms "ex-vivo," "ex-situ," "machine," and "perfusion." Weight gain, an indicator of organ viability, was chosen to compare outcomes. Extracted variables included perfused organ, warm and cold ischemia time before perfusion, perfusion duration, perfusate flow, pressure, temperature, perfusate composition (presence of cellular or acellular oxygen carrier, colloids, and other supplements) and percent weight change. Data were analyzed using SPSS statistical software. Overall, 44 articles were included. Red blood cell-based perfusates resulted in significantly lower weight gain compared to acellular perfusates without oxygen carriers (11.3% vs. 27.0%, p < 0.001). Hemoglobin-based oxygen carriers resulted in significantly lower weight gain compared to acellular perfusates (16.5% vs. 27%, p = 0.006). Normothermic perfusion led to the least weight gain (14.6%), significantly different from hypothermic (24.3%) and subnormothermic (25.0%) conditions (p < 0.001), with no significant difference between hypothermic and subnormothermic groups (24.3% vs. 25.0%, p = 0.952). There was a positive correlation between flow rate and weight gain (ß = 13.1, R = 0.390, p < 0.001). Oxygen carriers, low flow rates, and normothermic perfusate temperature appear to improve outcomes in EVMP. These findings offer opportunities for improving organ transplantation outcomes. |
| Author | Abbas, Fuad Marlar, Riley Frisbie, Sean Sims, Jack Rampazzo, Antonio Ghazoul, Adam Bassiri Gharb, Bahar Rezaee, Ava Obeid, Rommy |
| AuthorAffiliation | 1 Department of Plastic Surgery Cleveland Clinic Cleveland Ohio USA |
| AuthorAffiliation_xml | – name: 1 Department of Plastic Surgery Cleveland Clinic Cleveland Ohio USA |
| Author_xml | – sequence: 1 givenname: Riley orcidid: 0009-0006-4269-214X surname: Marlar fullname: Marlar, Riley organization: Cleveland Clinic – sequence: 2 givenname: Fuad surname: Abbas fullname: Abbas, Fuad organization: Cleveland Clinic – sequence: 3 givenname: Rommy surname: Obeid fullname: Obeid, Rommy organization: Cleveland Clinic – sequence: 4 givenname: Sean surname: Frisbie fullname: Frisbie, Sean organization: Cleveland Clinic – sequence: 5 givenname: Adam surname: Ghazoul fullname: Ghazoul, Adam organization: Cleveland Clinic – sequence: 6 givenname: Ava surname: Rezaee fullname: Rezaee, Ava organization: Cleveland Clinic – sequence: 7 givenname: Jack surname: Sims fullname: Sims, Jack organization: Cleveland Clinic – sequence: 8 givenname: Antonio surname: Rampazzo fullname: Rampazzo, Antonio organization: Cleveland Clinic – sequence: 9 givenname: Bahar surname: Bassiri Gharb fullname: Bassiri Gharb, Bahar email: bassirb@ccf.org organization: Cleveland Clinic |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39157933$$D View this record in MEDLINE/PubMed |
| BookMark | eNp10d1qFDEUAOAgFbutXvgCMuCNXkx7ziaZyVzJUuoPFApiwbuQnTnZpswmazKzde_6CD6Cz-Kj-CRm3f6oYAiEQ75zOJxzwPZ88MTYc4QjzOfYhHiEQgl8xCYop7JE2Yg9NgGsoJSV-LzPDlK6AoBaQPWE7fMGZd1wPmEXs2JJg_l5881402-SS0WwxYqiHZMLvliZaDKgmApjLbWD84vimtzicigWxvkiX_r64_varcND2lP22Jo-0bPb95BdvD39dPK-PDt_9-Fkdla2AgSWzVwZ1SFYUKJrlUKJnbCylYpa7HJE07kVZDtureKC6qbCuTRWWA7AoeaH7M2u7mqcL6lryQ_R9HoV3dLEjQ7G6b9_vLvUi7DWiJWqp6ByhVe3FWL4MlIa9NKllvreeApj0hwaIeppjVv68h96FcaYp5YVSuDYgNqqF3-2dN_L3cgzeL0DbQwpRbL3BEFv16nzOvXvdWZ7vLPXrqfN_6GenX_cZfwC07SjHQ |
| Cites_doi | 10.1111/tri.12468 10.3390/cells10040748 10.1111/aor.14442 10.1097/MOT.0000000000000961 10.1016/j.freeradbiomed.2003.11.030 10.1038/aps.2017.182 10.1097/TP.0000000000001661 10.1097/TP.0000000000001500 10.1111/aor.13678 10.1159/000499610 10.1177/1535370219834498 10.1038/nbt0798‐672 10.1097/00000658-197602000-00016 10.1097/MAT.0000000000001597 10.1097/TP.0000000000004045 10.1016/j.transproceed.2020.05.007 10.1016/S0003‐4975(03)00191‐7 10.1016/j.transproceed.2019.03.042 10.3724/zdxbyxb‐2022‐0402 10.1097/TA.0000000000003688 10.1016/j.healun.2016.01.494 10.1111/j.1525‐1594.2009.00743.x 10.1002/bjs.11921 10.1016/j.cjtee.2023.05.005 10.1111/tri.12319 10.1172/jci.insight.128833 10.1159/000445432 10.1016/j.transproceed.2010.02.073 10.3390/ijms242316693 10.1016/0022‐4804(85)90039‐3 10.1016/j.healun.2014.09.021 10.12659/AOT.893784 10.1016/j.jss.2020.11.069 10.1111/ajt.13843 10.1097/TP.0000000000004380 10.1097/TP.0000000000000756 10.1097/GOX.0000000000004123 10.12659/AOT.890797 10.3390/ijms21218156 10.1038/nm.2507 10.1186/s13019‐020‐01223‐x 10.3109/00365598009179578 10.3389/frtra.2023.1323387 10.1186/s13054‐014‐0644‐4 10.1111/ctr.12680 10.1016/j.jss.2016.08.068 10.1016/j.athoracsur.2008.09.049 10.5500/wjt.v10.i1.15 10.1016/j.jhsa.2015.11.003 10.3390/ijms232012656 10.1038/s41587‐019‐0374‐x 10.1111/aor.14085 10.1093/milmed/usz314 10.1016/j.ejcts.2008.03.043 10.1371/journal.pone.0266207 10.1016/j.ajpath.2020.10.001 10.1016/j.jtcvs.2017.02.072 10.1152/ajpgi.1983.245.6.G769 10.1152/ajprenal.1981.241.2.F139 10.21037/jtd‐2021‐23 10.1055/a‐1886‐5697 10.1093/milmed/usaa160 10.1016/S0022-5223(19)35161-X 10.1111/aor.14351 10.1016/j.jss.2021.09.005 10.1111/aor.12867 10.1002/lt.24972 10.1002/micr.30252 10.1111/aor.14066 10.1034/j.1399‐3089.2002.0o140.x 10.1097/TP.0000000000003221 10.1016/j.cryobiol.2015.07.006 10.1021/acs.cgd.1c00730 10.1186/2047‐1440‐1‐18 10.1097/TA.0000000000003395 10.1152/ajplung.00053.2020 10.1016/j.jss.2022.11.003 |
| ContentType | Journal Article |
| Copyright | 2024 The Author(s). published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. 2024 The Author(s). Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. 2024. This work is published under Creative Commons Attribution License~https://creativecommons.org/licenses/by/3.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: 2024 The Author(s). published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. – notice: 2024 The Author(s). Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. – notice: 2024. This work is published under Creative Commons Attribution License~https://creativecommons.org/licenses/by/3.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 24P AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QO 8FD FR3 K9. P64 7X8 5PM |
| DOI | 10.1111/aor.14841 |
| DatabaseName | Wiley Online Library Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Biotechnology Research Abstracts Technology Research Database Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Engineering Research Database Biotechnology Research Abstracts Technology Research Database Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic ProQuest Health & Medical Complete (Alumni) MEDLINE |
| Database_xml | – sequence: 1 dbid: 24P name: Wiley Online Library Open Access url: https://authorservices.wiley.com/open-science/open-access/browse-journals.html sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| DocumentTitleAlternate | Determinants of Success in Ex Vivo Perfusion |
| EISSN | 1525-1594 |
| EndPage | 20 |
| ExternalDocumentID | PMC11687208 39157933 10_1111_aor_14841 AOR14841 |
| Genre | reviewArticle Meta-Analysis Systematic Review Journal Article |
| GroupedDBID | --- .3N .GA .GJ .Y3 05W 0R~ 10A 1OB 1OC 23N 24P 31~ 33P 36B 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5RE 5VS 66C 6P2 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAESR AAEVG AAHHS AAHQN AAIPD AAMNL AANHP AANLZ AAONW AASGY AAXRX AAYCA AAZKR ABCQN ABCUV ABDBF ABEML ABJNI ABPVW ABQWH ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACGOF ACIWK ACMXC ACPOU ACPRK ACRPL ACSCC ACUHS ACXBN ACXQS ACYXJ ADBBV ADBTR ADEOM ADIZJ ADKYN ADMGS ADNMO ADOZA ADXAS ADZMN ADZOD AEEZP AEIGN AEIMD AENEX AEQDE AEUQT AEUYR AFBPY AFEBI AFFNX AFFPM AFGKR AFPWT AFRAH AFWVQ AFZJQ AHBTC AHEFC AHMBA AIACR AITYG AIURR AIWBW AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN ALVPJ AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BDRZF BFHJK BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DPXWK DR2 DRFUL DRMAN DRSTM EAD EAP EBC EBD EBS EJD EMB EMK EMOBN EST ESX EX3 F00 F01 F04 F5P FEDTE FUBAC G-S G.N GODZA H.X HF~ HGLYW HKTDT HVGLF HZI HZ~ IHE IX1 J0M K48 KBYEO LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MEWTI MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ O66 O9- OIG OVD P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 R.K RIWAO RJQFR ROL RX1 SAMSI SUPJJ SV3 TEORI TUS UB1 W8V W99 WBKPD WHWMO WIH WIJ WIK WOHZO WOW WQJ WRC WUP WVDHM WXI WXSBR XG1 YFH ZGI ZXP ZZTAW ~IA ~WT AAMMB AAYXX AEFGJ AEYWJ AGHNM AGQPQ AGXDD AGYGG AIDQK AIDYY AIQQE CITATION O8X CGR CUY CVF ECM EIF NPM 7QO 8FD FR3 K9. P64 7X8 5PM |
| ID | FETCH-LOGICAL-c4041-9b8a8d10f084dc88151d4f5c58ec1d151e2bf4efd3ff834e7961b5af4f3003073 |
| IEDL.DBID | 24P |
| ISICitedReferencesCount | 1 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001293232500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0160-564X 1525-1594 |
| IngestDate | Tue Nov 04 02:04:42 EST 2025 Fri Sep 05 11:48:10 EDT 2025 Sat Nov 29 14:54:22 EST 2025 Sun Jul 13 01:33:43 EDT 2025 Sat Nov 29 07:35:07 EST 2025 Wed Jan 22 17:11:36 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | preservation ex‐situ perfusion ex‐vivo perfusion machine perfusion perfusion ex vivo organ perfusion weight gain ex vivo ex vivo machine perfusion |
| Language | English |
| License | Attribution 2024 The Author(s). Artificial Organs published by International Center for Artificial Organ and Transplantation (ICAOT) and Wiley Periodicals LLC. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c4041-9b8a8d10f084dc88151d4f5c58ec1d151e2bf4efd3ff834e7961b5af4f3003073 |
| Notes | ObjectType-Article-1 ObjectType-Evidence Based Healthcare-3 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-4 content type line 23 ObjectType-Undefined-3 |
| ORCID | 0009-0006-4269-214X |
| OpenAccessLink | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Faor.14841 |
| PMID | 39157933 |
| PQID | 3150319088 |
| PQPubID | 1026359 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_11687208 proquest_miscellaneous_3094472718 proquest_journals_3150319088 pubmed_primary_39157933 crossref_primary_10_1111_aor_14841 wiley_primary_10_1111_aor_14841_AOR14841 |
| PublicationCentury | 2000 |
| PublicationDate | January 2025 |
| PublicationDateYYYYMMDD | 2025-01-01 |
| PublicationDate_xml | – month: 01 year: 2025 text: January 2025 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Geesthacht – name: Hoboken |
| PublicationTitle | Artificial organs |
| PublicationTitleAlternate | Artif Organs |
| PublicationYear | 2025 |
| Publisher | Wiley Subscription Services, Inc John Wiley and Sons Inc |
| Publisher_xml | – name: Wiley Subscription Services, Inc – name: John Wiley and Sons Inc |
| References | 2015; 34 2023; 30 2017; 41 2019; 51 2009; 87 2021; 23 2023; 39 2015; 71 2004; 9 2022; 23 2022; 68 2008; 34 2016; 30 2020; 15 2023; 2 2023; 107 2020; 10 2017; 154 2011; 17 2022; 27 2019; 244 2016; 35 1998; 16 2017; 208 2018; 39 2023; 24 2020; 52 2004; 36 2016; 41 2014; 19 2020; 44 2014; 18 2018; 38 2021; 191 2010; 8 2023; 51 2019; 4 2022; 270 1976; 183 2022; 92 2002; 9 2023; 18 2020; 185 2022; 93 2023; 283 1981; 241 2021; 108 2015; 99 2020; 104 2020; 38 2022; 46 2021; 260 1988; 96 2016; 16 2016; 57 2003; 76 2018; 24 2009; 33 2021; 13 2010; 42 1980; 14 2015; 28 2021; 10 1983; 245 2023; 47 2012; 1 2015; 20 2019; 46 2022; 10 2020; 21 2017; 101 2022; 106 1985; 38 2020; 319 e_1_2_10_23_1 e_1_2_10_46_1 e_1_2_10_69_1 e_1_2_10_21_1 e_1_2_10_44_1 e_1_2_10_42_1 e_1_2_10_40_1 e_1_2_10_70_1 e_1_2_10_2_1 e_1_2_10_72_1 e_1_2_10_4_1 e_1_2_10_18_1 e_1_2_10_74_1 e_1_2_10_53_1 e_1_2_10_6_1 e_1_2_10_16_1 e_1_2_10_39_1 e_1_2_10_76_1 e_1_2_10_55_1 e_1_2_10_8_1 e_1_2_10_14_1 e_1_2_10_37_1 e_1_2_10_57_1 e_1_2_10_78_1 Karcz M (e_1_2_10_32_1) 2010; 8 e_1_2_10_58_1 e_1_2_10_13_1 e_1_2_10_34_1 e_1_2_10_11_1 e_1_2_10_30_1 e_1_2_10_51_1 e_1_2_10_80_1 e_1_2_10_29_1 e_1_2_10_63_1 e_1_2_10_27_1 e_1_2_10_65_1 e_1_2_10_25_1 e_1_2_10_48_1 e_1_2_10_67_1 e_1_2_10_24_1 e_1_2_10_45_1 e_1_2_10_22_1 e_1_2_10_43_1 e_1_2_10_20_1 e_1_2_10_41_1 e_1_2_10_71_1 e_1_2_10_73_1 e_1_2_10_52_1 e_1_2_10_3_1 e_1_2_10_19_1 e_1_2_10_75_1 e_1_2_10_54_1 e_1_2_10_5_1 e_1_2_10_17_1 e_1_2_10_38_1 e_1_2_10_77_1 e_1_2_10_56_1 e_1_2_10_79_1 e_1_2_10_7_1 e_1_2_10_15_1 e_1_2_10_36_1 e_1_2_10_12_1 e_1_2_10_35_1 e_1_2_10_9_1 e_1_2_10_59_1 e_1_2_10_10_1 e_1_2_10_33_1 e_1_2_10_31_1 e_1_2_10_50_1 Wilson CH (e_1_2_10_61_1) 2004; 9 e_1_2_10_60_1 e_1_2_10_62_1 e_1_2_10_64_1 e_1_2_10_28_1 e_1_2_10_49_1 e_1_2_10_66_1 e_1_2_10_26_1 e_1_2_10_47_1 e_1_2_10_68_1 |
| References_xml | – volume: 87 start-page: 255 issue: 1 year: 2009 end-page: 260 article-title: Clinical transplantation of initially rejected donor lungs after reconditioning ex vivo publication-title: Ann Thorac Surg – volume: 51 start-page: 697 issue: 6 year: 2023 end-page: 706 article-title: Application of a novel artificial perfusate based on oxygen‐carrying nanoparticles in normothermic machine perfusion for porcine liver preservation after cardiac death publication-title: J Zhejiang Univ (Med Sci) – volume: 30 start-page: 114 year: 2023 end-page: 120 article-title: Study on the preservation effects of the amputated forelimb by machine perfusion at physiological temperature publication-title: Chin J Traumatol – volume: 20 start-page: 461 year: 2015 end-page: 468 article-title: Twelve‐hour hypothermic machine perfusion for donor heart preservation leads to improved ultrastructural characteristics compared to conventional cold storage publication-title: Ann Transplant – volume: 42 start-page: 1591 issue: 5 year: 2010 end-page: 1594 article-title: Importance of organ preservation solution composition in reducing myocardial edema during machine perfusion for heart transplantation publication-title: Transplant Proc – volume: 8 start-page: 55 issue: 1 year: 2010 end-page: 60 article-title: An ex‐vivo model for hypothermic pulsatile perfusion of porcine pancreata: hemodynamic and morphologic characteristics publication-title: Exp Clin Transplant – volume: 270 start-page: 151 year: 2022 end-page: 161 article-title: Optimization of ex vivo machine perfusion and transplantation of vascularized composite allografts publication-title: J Surg Res – volume: 24 start-page: 233 issue: 2 year: 2018 end-page: 245 article-title: Lipid metabolism and functional assessment of discarded human livers with steatosis undergoing 24 hours of normothermic machine perfusion publication-title: Liver Transpl – volume: 191 start-page: 52 issue: 1 year: 2021 end-page: 65 article-title: Mechanisms of endothelial regeneration and vascular repair and their application to regenerative medicine publication-title: Am J Pathol – volume: 33 start-page: 565 issue: 7 year: 2009 end-page: 570 article-title: An in vivo autotransplant model of renal preservation: cold storage versus machine perfusion in the prevention of ischemia/reperfusion injury publication-title: Artif Organs – volume: 68 start-page: 461 issue: 4 year: 2022 end-page: 470 article-title: The use of hemoglobin‐based oxygen carriers in ex vivo machine perfusion of donor organs for transplantation publication-title: ASAIO J – volume: 154 start-page: 1811 issue: 5 year: 2017 end-page: 1820 article-title: Lungs donated after circulatory death and prolonged warm ischemia are transplanted successfully after enhanced ex vivo lung perfusion using adenosine A2B receptor antagonism publication-title: J Thorac Cardiovasc Surg – volume: 47 start-page: 290 issue: 2 year: 2023 end-page: 301 article-title: Weight gain is an early indicator of injury in ex vivo normothermic limb perfusion (EVNLP) publication-title: Artif Organs – volume: 1 issue: 1 year: 2012 article-title: The influence of perfusion solution on renal graft viability assessment publication-title: Transp Res – volume: 24 issue: 23 year: 2023 article-title: Donor heart preservation: current knowledge and the new era of machine perfusion publication-title: Int J Mol Sci – volume: 71 start-page: 244 issue: 2 year: 2015 end-page: 255 article-title: Machine perfusion enhances hepatocyte isolation yields from ischemic livers publication-title: Cryobiology – volume: 108 start-page: 574 issue: 5 year: 2021 end-page: 582 article-title: Randomized preclinical study of machine perfusion in vascularized composite allografts publication-title: Br J Surg – volume: 10 start-page: 15 issue: 1 year: 2020 end-page: 28 article-title: Machine perfusion in abdominal organ transplantation: current use in The Netherlands publication-title: World J Transplant – volume: 44 start-page: 846 issue: 8 year: 2020 end-page: 855 article-title: Extended ex vivo normothermic perfusion for preservation of vascularized composite allografts publication-title: Artif Organs – volume: 21 start-page: 8156 issue: 21 year: 2020 article-title: In vitro/ex vivo models for the study of ischemia reperfusion injury during kidney perfusion publication-title: Int J Mol Sci – volume: 208 start-page: 219 year: 2017 end-page: 229 article-title: An ex vivo comparison of adenosine and lidocaine solution and University of Wisconsin solution for hypothermic machine perfusion of porcine kidneys: potential for development publication-title: J Surg Res – volume: 57 start-page: 89 issue: 1–2 year: 2016 end-page: 99 article-title: Capsulotomy of Ischemically damaged donor kidneys: a pig study publication-title: Eur Surg Res – volume: 38 start-page: 189 issue: 2 year: 2020 end-page: 198 article-title: An integrated perfusion machine preserves injured human livers for 1 week publication-title: Nat Biotechnol – volume: 93 start-page: S102 issue: 2S year: 2022 end-page: S109 article-title: Proof of concept study for a closed ex vivo limb perfusion system for 24‐hour subnormothermic preservation using acellular perfusate publication-title: J Trauma Acute Care Surg – volume: 46 start-page: 281 issue: 2 year: 2022 end-page: 295 article-title: Clinical assessment of liver metabolism during hypothermic oxygenated machine perfusion using microdialysis publication-title: Artif Organs – volume: 96 start-page: 930 issue: 6 year: 1988 end-page: 938 article-title: Oxygenated perfluorocarbon, recombinant human superoxide dismutase, and catalase ameliorate free radical induced myocardial injury during heart preservation and transplantation publication-title: J Thorac Cardiovasc Surg – volume: 13 start-page: 6602 issue: 11 year: 2021 end-page: 6617 article-title: Ex vivo lung perfusion publication-title: J Thorac Dis – volume: 41 start-page: E240 issue: 11 year: 2017 end-page: E250 article-title: Development and evaluation of heartbeat: a machine perfusion heart preservation system publication-title: Artif Organs – volume: 17 start-page: 1391 issue: 11 year: 2011 end-page: 1401 article-title: Ischemia and reperfusion—from mechanism to translation publication-title: Nat Med – volume: 35 start-page: S178 issue: 4 year: 2016 article-title: Polymerized human serum albumin as an osmotic molecule to support ex‐vivo lung perfusion publication-title: J Heart Lung Transplant – volume: 19 start-page: 409 year: 2014 end-page: 416 article-title: Preservation of donor hearts using hypothermic oxygenated perfusion publication-title: Ann Transplant – volume: 18 issue: 1 year: 2023 article-title: Development of a rat forelimb vascularized composite allograft (VCA) perfusion protocol publication-title: PLoS One – volume: 183 start-page: 179 issue: 2 year: 1976 end-page: 184 article-title: Aspiration pneumonia: experimental evaluation of albumin and steroid therapy publication-title: Ann Surg – volume: 28 start-page: 224 issue: 2 year: 2015 end-page: 231 article-title: Hypothermic continuous machine perfusion improves metabolic preservation and functional recovery in heart grafts publication-title: Transpl Int – volume: 104 start-page: e260 issue: 9 year: 2020 end-page: e270 article-title: Hypothermic ex situ perfusion of human limbs with acellular solution for 24 hours publication-title: Transplantation – volume: 18 start-page: 644 issue: 6 year: 2014 article-title: Accuracy of invasive arterial pressure monitoring in cardiovascular patients: an observational study publication-title: Crit Care – volume: 2 year: 2023 article-title: Review of machine perfusion studies in vascularized composite allotransplant preservation publication-title: Front Transplant – volume: 39 start-page: 350 issue: 5 year: 2023 end-page: 360 article-title: Exceeding the limits of static cold storage in limb transplantation using subnormothermic machine perfusion publication-title: J Reconstr Microsurg – volume: 101 start-page: 1084 issue: 5 year: 2017 end-page: 1098 article-title: Normothermic perfusion in the assessment and preservation of declined livers before transplantation: hyperoxia and vasoplegia‐important lessons from the first 12 cases publication-title: Transplantation – volume: 4 issue: 11 year: 2019 article-title: The ex vivo human lung: research value for translational science publication-title: JCI Insight – volume: 260 start-page: 190 year: 2021 end-page: 199 article-title: Significance of lung weight in cellular ex vivo lung perfusion publication-title: J Surg Res – volume: 39 start-page: 845 issue: 5 year: 2018 end-page: 857 article-title: Organ preservation: from the past to the future publication-title: Acta Pharmacol Sin – volume: 38 start-page: 185 issue: 2 year: 2018 end-page: 194 article-title: Developing a protocol for normothermic ex‐situ limb perfusion publication-title: Microsurgery – volume: 101 start-page: e68 issue: 3 year: 2017 end-page: e74 article-title: Ex situ perfusion of human limb allografts for 24 hours publication-title: Transplantation – volume: 30 start-page: 183 issue: 3 year: 2016 end-page: 194 article-title: Ex vivo lung perfusion publication-title: Clin Transpl – volume: 51 start-page: 2022 issue: 6 year: 2019 end-page: 2028 article-title: Continuous hemodialysis does not improve graft function during ex vivo lung perfusion over 24 hours publication-title: Transplant Proc – volume: 76 start-page: 244 issue: 1 year: 2003 end-page: 252 article-title: Transplantation of lungs from non–heart‐beating donors after functional assessment ex vivo publication-title: Ann Thorac Surg – volume: 92 start-page: 388 issue: 2 year: 2022 end-page: 397 article-title: Ex vivo normothermic preservation of amputated limbs with a hemoglobin‐based oxygen carrier perfusate publication-title: J Trauma Acute Care Surg – volume: 16 start-page: 672 issue: 7 year: 1998 end-page: 676 article-title: Rate of reaction with nitric oxide determines the hypertensive effect of cell‐free hemoglobin publication-title: Nat Biotechnol – volume: 99 start-page: 2095 issue: 10 year: 2015 end-page: 2101 article-title: Ex situ limb perfusion system to extend vascularized composite tissue allograft survival in swine publication-title: Transplantation – volume: 15 start-page: 1 issue: 1 year: 2020 end-page: 9 article-title: Temperature and flow rate limit the optimal ex‐vivo perfusion of the heart—an experimental study publication-title: J Cardiothorac Surg – volume: 107 start-page: 628 issue: 3 year: 2023 end-page: 638 article-title: Real‐time lung weight measurement during cellular ex vivo lung perfusion: an early predictor of transplant suitability publication-title: Transplantation – volume: 185 start-page: e2004 issue: 11–12 year: 2020 end-page: e2012 article-title: Comparison of acellular solutions for ex‐situ perfusion of amputated limbs publication-title: Mil Med – volume: 241 start-page: F139 issue: 2 year: 1981 end-page: F150 article-title: Effect of erythrocytes and globulin on renal functions of the isolated rat kidney publication-title: Am J Phys – volume: 245 start-page: G769 issue: 6 year: 1983 end-page: G774 article-title: Effects of hematocrit on oxygenation of the isolated perfused rat liver publication-title: Am J Phys – volume: 23 start-page: 5451 year: 2021 end-page: 5459 article-title: Human versus bovine serum albumin: a subtle difference in hydrophobicity leads to Large differences in bulk and Interface behavior publication-title: Cryst Growth Des – volume: 244 start-page: 630 issue: 8 year: 2019 end-page: 645 article-title: Bioengineering approaches to organ preservation ex vivo publication-title: Exp Biol Med – volume: 28 start-page: 657 issue: 6 year: 2015 end-page: 664 article-title: Normothermic machine perfusion of the kidney: better conditioning and repair? publication-title: Transpl Int – volume: 14 start-page: 288 issue: 3 year: 1980 end-page: 291 article-title: The significance of pH variations in human albumin perfusion media during continuous hypothermic renal perfusion publication-title: Scand J Urol Nephrol – volume: 10 issue: 2 year: 2022 article-title: 24‐hour perfusion of porcine myocutaneous flaps mitigates reperfusion injury: a 7‐day follow‐up study publication-title: Plast Reconstr Surg Glob Open – volume: 10 start-page: 748 issue: 4 year: 2021 article-title: Subnormothermic ex vivo lung perfusion temperature improves graft preservation in lung transplantation publication-title: Cells – volume: 16 start-page: 2932 issue: 10 year: 2016 end-page: 2942 article-title: Machine perfusion of donor livers for transplantation: a proposal for standardized nomenclature and reporting guidelines publication-title: Am J Transplant – volume: 46 start-page: 2493 issue: 12 year: 2022 end-page: 2499 article-title: A new ex‐situ machine perfusion device. A preliminary evaluation using a model of donors after circulatory death pig livers publication-title: Artif Organs – volume: 34 start-page: 318 issue: 2 year: 2008 end-page: 325 article-title: Preserving and evaluating hearts with ex vivo machine perfusion: an avenue to improve early graft performance and expand the donor pool publication-title: Eur J Cardiothorac Surg – volume: 34 start-page: 113 issue: 1 year: 2015 end-page: 121 article-title: A whole blood‐based perfusate provides superior preservation of myocardial function during ex vivo heart perfusion publication-title: J Heart Lung Transplant – volume: 27 start-page: 204 issue: 3 year: 2022 end-page: 210 article-title: Ex‐vivo lung perfusion therapies: do they add value to organ donation? publication-title: Curr Opin Organ Transplant – volume: 52 start-page: 2941 issue: 10 year: 2020 end-page: 2946 article-title: A low‐cost perfusate alternative for ex vivo lung perfusion publication-title: Transplant Proc – volume: 9 start-page: 36 issue: 1 year: 2002 end-page: 44 article-title: HDAF transgenic pig livers are protected from hyperacute rejection during ex vivo perfusion with human blood publication-title: Xenotransplantation – volume: 283 start-page: 1145 year: 2023 end-page: 1153 article-title: Continuous versus pulsatile flow in 24‐hour vascularized composite allograft machine perfusion in swine: a pilot study publication-title: J Surg Res – volume: 46 start-page: 151 issue: 3 year: 2019 end-page: 172 article-title: Organ preservation into the 2020s: the era of dynamic intervention publication-title: Transfus Med Hemother – volume: 46 start-page: 246 issue: 2 year: 2022 end-page: 258 article-title: Oxygenated machine perfusion at room temperature as an alternative for static cold storage in porcine donor hearts publication-title: Artif Organs – volume: 36 start-page: 685 issue: 6 year: 2004 end-page: 697 article-title: No scavenging and the hypertensive effect of hemoglobin‐based blood substitutes publication-title: Free Radic Biol Med – volume: 319 start-page: L218 issue: 2 year: 2020 end-page: L227 article-title: The ex vivo perfused human lung is resistant to injury by high‐dose bacteremia publication-title: Am J Physiol‐Lung Cell Mol Physiol – volume: 41 start-page: 3 issue: 1 year: 2016 end-page: 12 article-title: The effect of ex situ perfusion in a swine limb vascularized composite tissue allograft on survival up to 24 hours publication-title: J Hand Surg – volume: 38 start-page: 281 issue: 3 year: 1985 end-page: 288 article-title: Functional preservation of the mammalian kidney. VI. Viability assessment of rabbit kidneys perfused at 25 degrees C with dimethyl sulfoxide in RPS‐2 publication-title: J Surg Res – volume: 9 start-page: 31 issue: 2 year: 2004 end-page: 32 article-title: Weight increase during machine perfusion may be an indicator of organ and in particular, vascular damage publication-title: Ann Transplant – volume: 185 start-page: 110 issue: Suppl 1 year: 2020 end-page: 120 article-title: Ex‐vivo Normothermic limb perfusion with a hemoglobin‐based oxygen carrier perfusate publication-title: Mil Med – volume: 23 issue: 20 year: 2022 article-title: Inflammation in pulmonary hypertension and edema induced by hypobaric hypoxia exposure publication-title: Int J Mol Sci – volume: 106 start-page: 1638 issue: 8 year: 2022 end-page: 1646 article-title: Ex vivo normothermic perfusion of human upper limbs publication-title: Transplantation – ident: e_1_2_10_47_1 doi: 10.1111/tri.12468 – ident: e_1_2_10_62_1 doi: 10.3390/cells10040748 – ident: e_1_2_10_10_1 doi: 10.1111/aor.14442 – ident: e_1_2_10_67_1 doi: 10.1097/MOT.0000000000000961 – ident: e_1_2_10_69_1 doi: 10.1016/j.freeradbiomed.2003.11.030 – ident: e_1_2_10_4_1 doi: 10.1038/aps.2017.182 – ident: e_1_2_10_55_1 doi: 10.1097/TP.0000000000001661 – ident: e_1_2_10_51_1 doi: 10.1097/TP.0000000000001500 – ident: e_1_2_10_26_1 doi: 10.1111/aor.13678 – ident: e_1_2_10_80_1 doi: 10.1159/000499610 – ident: e_1_2_10_54_1 doi: 10.1177/1535370219834498 – ident: e_1_2_10_68_1 doi: 10.1038/nbt0798‐672 – ident: e_1_2_10_46_1 doi: 10.1097/00000658-197602000-00016 – ident: e_1_2_10_70_1 doi: 10.1097/MAT.0000000000001597 – ident: e_1_2_10_42_1 doi: 10.1097/TP.0000000000004045 – ident: e_1_2_10_7_1 doi: 10.1016/j.transproceed.2020.05.007 – ident: e_1_2_10_73_1 doi: 10.1016/S0003‐4975(03)00191‐7 – ident: e_1_2_10_21_1 doi: 10.1016/j.transproceed.2019.03.042 – ident: e_1_2_10_22_1 doi: 10.3724/zdxbyxb‐2022‐0402 – ident: e_1_2_10_50_1 doi: 10.1097/TA.0000000000003688 – ident: e_1_2_10_79_1 doi: 10.1016/j.healun.2016.01.494 – ident: e_1_2_10_33_1 doi: 10.1111/j.1525‐1594.2009.00743.x – ident: e_1_2_10_18_1 doi: 10.1002/bjs.11921 – ident: e_1_2_10_23_1 doi: 10.1016/j.cjtee.2023.05.005 – ident: e_1_2_10_64_1 doi: 10.1111/tri.12319 – ident: e_1_2_10_13_1 doi: 10.1172/jci.insight.128833 – ident: e_1_2_10_48_1 doi: 10.1159/000445432 – ident: e_1_2_10_24_1 doi: 10.1016/j.transproceed.2010.02.073 – ident: e_1_2_10_66_1 doi: 10.3390/ijms242316693 – ident: e_1_2_10_30_1 doi: 10.1016/0022‐4804(85)90039‐3 – ident: e_1_2_10_6_1 doi: 10.1016/j.healun.2014.09.021 – ident: e_1_2_10_36_1 doi: 10.12659/AOT.893784 – ident: e_1_2_10_11_1 doi: 10.1016/j.jss.2020.11.069 – ident: e_1_2_10_14_1 doi: 10.1111/ajt.13843 – ident: e_1_2_10_59_1 doi: 10.1097/TP.0000000000004380 – ident: e_1_2_10_39_1 doi: 10.1097/TP.0000000000000756 – ident: e_1_2_10_20_1 doi: 10.1097/GOX.0000000000004123 – ident: e_1_2_10_37_1 doi: 10.12659/AOT.890797 – ident: e_1_2_10_74_1 doi: 10.3390/ijms21218156 – ident: e_1_2_10_2_1 doi: 10.1038/nm.2507 – ident: e_1_2_10_75_1 doi: 10.1186/s13019‐020‐01223‐x – ident: e_1_2_10_38_1 doi: 10.3109/00365598009179578 – ident: e_1_2_10_65_1 doi: 10.3389/frtra.2023.1323387 – ident: e_1_2_10_76_1 doi: 10.1186/s13054‐014‐0644‐4 – ident: e_1_2_10_58_1 doi: 10.1111/ctr.12680 – ident: e_1_2_10_28_1 doi: 10.1016/j.jss.2016.08.068 – ident: e_1_2_10_60_1 doi: 10.1016/j.athoracsur.2008.09.049 – ident: e_1_2_10_63_1 doi: 10.5500/wjt.v10.i1.15 – ident: e_1_2_10_40_1 doi: 10.1016/j.jhsa.2015.11.003 – ident: e_1_2_10_71_1 doi: 10.3390/ijms232012656 – ident: e_1_2_10_25_1 doi: 10.1038/s41587‐019‐0374‐x – ident: e_1_2_10_49_1 doi: 10.1111/aor.14085 – ident: e_1_2_10_17_1 doi: 10.1093/milmed/usz314 – ident: e_1_2_10_56_1 doi: 10.1016/j.ejcts.2008.03.043 – ident: e_1_2_10_9_1 doi: 10.1371/journal.pone.0266207 – ident: e_1_2_10_12_1 doi: 10.1016/j.ajpath.2020.10.001 – ident: e_1_2_10_77_1 doi: 10.1016/j.jtcvs.2017.02.072 – ident: e_1_2_10_72_1 doi: 10.1152/ajpgi.1983.245.6.G769 – volume: 8 start-page: 55 issue: 1 year: 2010 ident: e_1_2_10_32_1 article-title: An ex‐vivo model for hypothermic pulsatile perfusion of porcine pancreata: hemodynamic and morphologic characteristics publication-title: Exp Clin Transplant – ident: e_1_2_10_44_1 doi: 10.1152/ajprenal.1981.241.2.F139 – ident: e_1_2_10_57_1 doi: 10.21037/jtd‐2021‐23 – ident: e_1_2_10_3_1 doi: 10.1055/a‐1886‐5697 – ident: e_1_2_10_29_1 doi: 10.1093/milmed/usaa160 – ident: e_1_2_10_19_1 doi: 10.1016/S0022-5223(19)35161-X – ident: e_1_2_10_27_1 doi: 10.1111/aor.14351 – ident: e_1_2_10_15_1 doi: 10.1016/j.jss.2021.09.005 – ident: e_1_2_10_34_1 doi: 10.1111/aor.12867 – ident: e_1_2_10_53_1 doi: 10.1002/lt.24972 – ident: e_1_2_10_5_1 doi: 10.1002/micr.30252 – ident: e_1_2_10_41_1 doi: 10.1111/aor.14066 – ident: e_1_2_10_35_1 doi: 10.1034/j.1399‐3089.2002.0o140.x – ident: e_1_2_10_8_1 doi: 10.1097/TP.0000000000003221 – ident: e_1_2_10_31_1 doi: 10.1016/j.cryobiol.2015.07.006 – ident: e_1_2_10_78_1 doi: 10.1021/acs.cgd.1c00730 – ident: e_1_2_10_52_1 doi: 10.1186/2047‐1440‐1‐18 – ident: e_1_2_10_16_1 doi: 10.1097/TA.0000000000003395 – ident: e_1_2_10_43_1 doi: 10.1152/ajplung.00053.2020 – ident: e_1_2_10_45_1 doi: 10.1016/j.jss.2022.11.003 – volume: 9 start-page: 31 issue: 2 year: 2004 ident: e_1_2_10_61_1 article-title: Weight increase during machine perfusion may be an indicator of organ and in particular, vascular damage publication-title: Ann Transplant |
| SSID | ssj0007406 |
| Score | 2.4068727 |
| SecondaryResourceType | review_article |
| Snippet | Background
Ex vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize... Ex vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize that there... Background Ex vivo machine perfusion (EVMP) has been established to extend viability of donor organs. However, EVMP protocols are inconsistent. We hypothesize... Oxygen carriers, lower flow rates, and normothermic perfusate temperature appear to improve outcomes in ex vivo machine perfusion. |
| SourceID | pubmedcentral proquest pubmed crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Publisher |
| StartPage | 7 |
| SubjectTerms | Cold flow Colloids Erythrocytes ex vivo ex vivo machine perfusion ex vivo organ perfusion ex‐situ perfusion ex‐vivo perfusion Flow velocity Hemoglobin Humans Ischemia Low flow machine perfusion Meta-analysis Organ Preservation - methods Organ Preservation Solutions Oxygen Parameters Perfusion Perfusion - methods preservation Systematic Review Weight Weight Gain |
| Title | A meta‐analysis of perfusion parameters affecting weight gain in ex vivo perfusion |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Faor.14841 https://www.ncbi.nlm.nih.gov/pubmed/39157933 https://www.proquest.com/docview/3150319088 https://www.proquest.com/docview/3094472718 https://pubmed.ncbi.nlm.nih.gov/PMC11687208 |
| Volume | 49 |
| WOSCitedRecordID | wos001293232500001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1525-1594 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0007406 issn: 0160-564X databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NitswEB5CUpZetn_bbto0qKWHvRgsW7YU9hTahh7SNIQGcjOyLG1zWDvkb_e4j7CP0Gfpo-yTdCQ7bkIoFArG2GhkC43mR6PRJ4APXFjIAi09HujQY5Iyu0jIvDTWfobq0FDlQFyHfDQSs1lv3IDL3V6YEh-iDrhZyXD62gq4TFd7Qi6LJYq5sJvWW5SG3A7pgI1rNcyZO1jTIqh5UcxmFayQTeOpqx4aoyMP8zhRct-BdRZo8OS_2v4UTivHk_TLkfIMGjp_Didfq6X1FzDtk2u9lg9397LCKSGFIQu9NBsbUCMWI_za5s6siHQ5IGjzyI0LrJIrOc8JXvr218_tfFv8qXYG08Hn7x-_eNWZC55iPqNeLxVSZNQ3vmCZEgIdgoyZSEVCK5rhmw5Sw7TJQmNEyDTvxTSNpGEmLPXFS2jmRa7PgXDKtBSxklwoptIs5X4vMyFH_qfSRFEb3u86P1mU0BrJbkqCHZS4DmpDZ8eWpJKuVRKiF4uqAxVkG97VxSgXdrFD5rrYIA3OWxk6ZxRpXpVcrP9iQfFRL4VtEAf8rQks5vZhST7_4bC3KY0FD3z86IVj8N9bnvS_TdzD638nfQOPA3u-sAvxdKC5Xm70W3iktuv5atl14xvvfCa60Po0GUyHvwF3vALJ |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NTtwwEB6hBUEvlJ9StuXHIA69RIo3TuyVuKzarkAsC0KstLfIcWzYAwnaPzj2EfoIfRYehSdh7GRTVqhSJaQcEnkcW54fj8fjzwBHXFjIAi093tCBxyRldpOQeUmk_RTNoaHKgbh2eLcr-v3m5QIcz87CFPgQVcDNaoaz11bBbUD6lZbLfIh6Luyp9UWGYhTWYPHHVbvXqSwxZ-5uTQui5oUR65fIQjaTp6o8Px-9cTLf5kq-9mHdJNT--L7ur8Fq6XySViEt67Cgsw1YPi-31zeh1yJ3eiyff_2WJVYJyQ2510MzsUE1YnHC72z-zIhIlweC8x55cMFVciMHGcFHPz79mQ6m-d9qn6DX_nn9_cQr713wFPMZ9ZqJkCKlvvEFS5UQ6BSkzIQqFFrRFL90IzFMmzQwRgRM82ZEk1AaZoLCZmxBLcszvQ2EU6aliJTkQjGVpAn3m6kJOMpAIk0Y1uFwNvrxfQGvEc-WJThAsRugOuzM-BKXGjaKA_Rk0XygkazDQVWMumE3PGSm8wnS4NqVoYNGkeZzwcaqFQuMj7YpqIOYY3BFYHG350uywa3D36Y0Erzh40-_OQ7_u-dx6-LKvXz5f9J9WDm5Pu_EndPu2Vf40LD3DbuQzw7UxsOJ3oUlNR0PRsO9UtxfAD5KBb4 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3NbtQwEB5VBVVc-KcsFHARBy6R4s0k9kq9rIBVEWW7QlTaW-T4p91Dk9X-tUcegUfgWfooPAljJ5t2VSEhIeWQyJPE8ng-j8fjzwDvhPSUBVZFomuTCBVHv0iIUZHZ2BAcOq4DieuRGA7leNwbbcHBei9MzQ_RBty8ZQS89gZup8bdsHJVzcjOpd-1fgdTwljP64yjFocFhpM1PYValGY4bniFfB5P--rmaHTLxbydKXnTgw1D0ODB_1X-IdxvXE_Wr_vKI9iy5WPY-dosrj-Bkz47twv1-8dP1TCVsMqxqZ25pQ-pMc8Sfu6zZ-ZMhSwQGvXYRQitslM1KRld9vLq12qyqq5fewong0_fPxxGzakLkcYYedQrpJKGxy6WaLSU5BIYdKlOpdXc0JPtFg6tM4lzMkErehkvUuXQJTViPIPtsirtc2CCo1Uy00pIjbowhYh7xiWCekChXJp24O269fNpTa6Rrycl1EB5aKAO7K31kjf2Nc8T8mMJPAgiO7DfFpNl-OUOVdpqSTI0c0VyzzjJ7NZqbP_iafEJmZIOyA0FtwKedXuzpJycBfZtzjMpujF99H3Q8N9rnvePv4WbF_8u-gZ2Rh8H-dHn4ZeXcK_rDxsO8Z492F7MlvYV3NWrxWQ-ex36-h8onAOn |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+meta%E2%80%90analysis+of+perfusion+parameters+affecting+weight+gain+in+ex%C2%A0vivo+perfusion&rft.jtitle=Artificial+organs&rft.au=Marlar%2C+Riley&rft.au=Abbas%2C+Fuad&rft.au=Obeid%2C+Rommy&rft.au=Frisbie%2C+Sean&rft.date=2025-01-01&rft.issn=0160-564X&rft.eissn=1525-1594&rft.volume=49&rft.issue=1&rft.spage=7&rft.epage=20&rft_id=info:doi/10.1111%2Faor.14841&rft.externalDBID=10.1111%252Faor.14841&rft.externalDocID=AOR14841 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0160-564X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0160-564X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0160-564X&client=summon |