Neurogenic and anti-inflammatory effects of probiotics in Parkinson’s disease: A systematic review of preclinical and clinical evidence

•Probiotics reduce markers of peripheral inflammation in PD.•Preclinical evidence suggests neuroprotective properties of probiotics in PD.•Probiotics activate the GLP-1 and PPAR-γ pathway in PD.•Future research should further explore the effects of probiotics on neuropsychiatric aspects of PD. There...

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Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 98; pp. 59 - 73
Main Authors:	Leta, Valentina, Ray Chaudhuri, K., Milner, Oliver, Chung-Faye, Guy, Metta, Vinod, Pariante, Carmine M., Borsini, Alessandra
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.11.2021
Subjects:	Anti-Inflammatory Agents - therapeutic use Brain-Gut Axis Dopaminergic Neurons Humans Inflammation Metabolism Motor symptoms Neurodegeneration Non-motor symptoms Parkinson Disease - drug therapy Parkinson’s disease Probiotics Probiotics - therapeutic use CRP GLP-1 BDNF Non-motor symptoms Inflammation Iba1 Metabolism IL-6 PPARγ GFAP Probiotics TH TNF-α Neurodegeneration SN GSH Parkinson’s disease Motor symptoms
ISSN:	0889-1591, 1090-2139, 1090-2139
Online Access:	Get full text
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