Heparan Sulfate–Rich Anionic Sites in the Human Glomerular Basement Membrane Decreased Concentration in Congenital Nephrotic Syndrome

Recent work suggests that the normal barrier to penetration of the renal glomerular basement membrane by anionic plasma proteins may depend in part on the existence of negatively charged sites within the membrane. We describe an in vitro cytochemical method for the quantitative demonstration of anio...

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 309; no. 17; pp. 1001 - 1009
Main Authors:	Vernier, Robert L, Klein, David J, Sisson, Susan P, Mahan, John D, Oegema, Theodore R, Brown, David M
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 27.10.1983
Subjects:	Acids Anions Basement Membrane - analysis Basement Membrane - metabolism Basement Membrane - ultrastructure Basement membranes Biopsy Bone surgery Child, Preschool Children & youth Enzymes Fetus - metabolism Fetuses Glycosaminoglycans - metabolism Heparan sulfate Heparin Lyase Heparitin Sulfate - metabolism Humans Infant Kidney Glomerulus - analysis Kidney Glomerulus - embryology Kidney Glomerulus - metabolism Kidney Glomerulus - ultrastructure Kidneys Laboratories Microscopy Nephrotic syndrome Nephrotic Syndrome - congenital Nephrotic Syndrome - metabolism Patients Pediatrics Perfusion Plasma proteins Polyethyleneimine - pharmacology Polysaccharide-Lyases - pharmacology Proteinuria - etiology Rodents Sucrose Sulfates Transplants & implants
ISSN:	0028-4793, 1533-4406
Online Access:	Get full text
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