Therapeutic outcomes evaluation of adjuvant hyperbaric oxygen therapy for non-healing diabetic foot ulcers among sudanese patients
Diabetic foot ulcers (DFUs) are common complications of diabetes that frequently lead to amputation and disability. Despite some promising results in using hyperbaric oxygen therapy (HBOT) for DFUs treatment, its efficacy is still debatable. The aim of this study was to evaluate the therapeutic outc...
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| Published in: | Diabetes & metabolic syndrome clinical research & reviews Vol. 15; no. 4; p. 102173 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier Ltd
01.07.2021
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| ISSN: | 1871-4021, 1878-0334, 1878-0334 |
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| Abstract | Diabetic foot ulcers (DFUs) are common complications of diabetes that frequently lead to amputation and disability. Despite some promising results in using hyperbaric oxygen therapy (HBOT) for DFUs treatment, its efficacy is still debatable. The aim of this study was to evaluate the therapeutic outcomes of adjuvant HBOT in non-healing DFUs treatment.
A descriptive, retrospective, hospital-based study was conducted at Al–Mo'alem Medical City-Khartoum, Sudan from August to December 2018. Medical records of Type 2 diabetic patients, treated with HBOT plus standard wound care for DFUs, were included in the study. Data were analyzed by simple descriptive statistics and logistic regression. P ≤ 0.05 was considered statistically significant.
The study results showed that 51.7% of patients had Wagner grade-3 ulcers and 28.3% had complete loss of protective sensation. Almost 61% of patients achieved complete ulcer healing while 16.7% underwent amputation. Twenty percent of patients treated with HBOT experienced ear barotraumas as adverse effects. Protective sensation (OR = 6.00, 95% CI = 1.79–20.16, p = 0.004) and more sessions of HBOT (OR = 17.35, 95% CI = 4.51–66.73, p = 0.000) were positive predictors of complete ulcer healing. Loss of protective sensation (OR = 0.17, 95% CI = 0.05–0.63, p = 0.007) was an indicator of amputation.
Treatment with adjuvant HBOT enhanced ulcer healing and reduced amputation rate in patients with non-healing DFUs. HBOT could be considered a relatively safe intervention.
Adjunctive hyperbaric oxygen therapy (HBOT) improves ulcer healing in patient with non-healing diabetic foot ulcers (DFUs)HBOT reduces the risk of amputation in patients with chronic DFUsThe presence of protective sensation and the greater number of HBOT sessions are positive predictors of complete ulcer healingAmputation is positively associated with peripheral neuropathy in patients with refractory DFUs |
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| AbstractList | Diabetic foot ulcers (DFUs) are common complications of diabetes that frequently lead to amputation and disability. Despite some promising results in using hyperbaric oxygen therapy (HBOT) for DFUs treatment, its efficacy is still debatable. The aim of this study was to evaluate the therapeutic outcomes of adjuvant HBOT in non-healing DFUs treatment.BACKGROUND AND AIMSDiabetic foot ulcers (DFUs) are common complications of diabetes that frequently lead to amputation and disability. Despite some promising results in using hyperbaric oxygen therapy (HBOT) for DFUs treatment, its efficacy is still debatable. The aim of this study was to evaluate the therapeutic outcomes of adjuvant HBOT in non-healing DFUs treatment.A descriptive, retrospective, hospital-based study was conducted at Al-Mo'alem Medical City-Khartoum, Sudan from August to December 2018. Medical records of Type 2 diabetic patients, treated with HBOT plus standard wound care for DFUs, were included in the study. Data were analyzed by simple descriptive statistics and logistic regression. P ≤ 0.05 was considered statistically significant.METHODSA descriptive, retrospective, hospital-based study was conducted at Al-Mo'alem Medical City-Khartoum, Sudan from August to December 2018. Medical records of Type 2 diabetic patients, treated with HBOT plus standard wound care for DFUs, were included in the study. Data were analyzed by simple descriptive statistics and logistic regression. P ≤ 0.05 was considered statistically significant.The study results showed that 51.7% of patients had Wagner grade-3 ulcers and 28.3% had complete loss of protective sensation. Almost 61% of patients achieved complete ulcer healing while 16.7% underwent amputation. Twenty percent of patients treated with HBOT experienced ear barotraumas as adverse effects. Protective sensation (OR = 6.00, 95% CI = 1.79-20.16, p = 0.004) and more sessions of HBOT (OR = 17.35, 95% CI = 4.51-66.73, p = 0.000) were positive predictors of complete ulcer healing. Loss of protective sensation (OR = 0.17, 95% CI = 0.05-0.63, p = 0.007) was an indicator of amputation.RESULTSThe study results showed that 51.7% of patients had Wagner grade-3 ulcers and 28.3% had complete loss of protective sensation. Almost 61% of patients achieved complete ulcer healing while 16.7% underwent amputation. Twenty percent of patients treated with HBOT experienced ear barotraumas as adverse effects. Protective sensation (OR = 6.00, 95% CI = 1.79-20.16, p = 0.004) and more sessions of HBOT (OR = 17.35, 95% CI = 4.51-66.73, p = 0.000) were positive predictors of complete ulcer healing. Loss of protective sensation (OR = 0.17, 95% CI = 0.05-0.63, p = 0.007) was an indicator of amputation.Treatment with adjuvant HBOT enhanced ulcer healing and reduced amputation rate in patients with non-healing DFUs. HBOT could be considered a relatively safe intervention.CONCLUSIONSTreatment with adjuvant HBOT enhanced ulcer healing and reduced amputation rate in patients with non-healing DFUs. HBOT could be considered a relatively safe intervention. Diabetic foot ulcers (DFUs) are common complications of diabetes that frequently lead to amputation and disability. Despite some promising results in using hyperbaric oxygen therapy (HBOT) for DFUs treatment, its efficacy is still debatable. The aim of this study was to evaluate the therapeutic outcomes of adjuvant HBOT in non-healing DFUs treatment. A descriptive, retrospective, hospital-based study was conducted at Al–Mo'alem Medical City-Khartoum, Sudan from August to December 2018. Medical records of Type 2 diabetic patients, treated with HBOT plus standard wound care for DFUs, were included in the study. Data were analyzed by simple descriptive statistics and logistic regression. P ≤ 0.05 was considered statistically significant. The study results showed that 51.7% of patients had Wagner grade-3 ulcers and 28.3% had complete loss of protective sensation. Almost 61% of patients achieved complete ulcer healing while 16.7% underwent amputation. Twenty percent of patients treated with HBOT experienced ear barotraumas as adverse effects. Protective sensation (OR = 6.00, 95% CI = 1.79–20.16, p = 0.004) and more sessions of HBOT (OR = 17.35, 95% CI = 4.51–66.73, p = 0.000) were positive predictors of complete ulcer healing. Loss of protective sensation (OR = 0.17, 95% CI = 0.05–0.63, p = 0.007) was an indicator of amputation. Treatment with adjuvant HBOT enhanced ulcer healing and reduced amputation rate in patients with non-healing DFUs. HBOT could be considered a relatively safe intervention. Adjunctive hyperbaric oxygen therapy (HBOT) improves ulcer healing in patient with non-healing diabetic foot ulcers (DFUs)HBOT reduces the risk of amputation in patients with chronic DFUsThe presence of protective sensation and the greater number of HBOT sessions are positive predictors of complete ulcer healingAmputation is positively associated with peripheral neuropathy in patients with refractory DFUs Diabetic foot ulcers (DFUs) are common complications of diabetes that frequently lead to amputation and disability. Despite some promising results in using hyperbaric oxygen therapy (HBOT) for DFUs treatment, its efficacy is still debatable. The aim of this study was to evaluate the therapeutic outcomes of adjuvant HBOT in non-healing DFUs treatment. A descriptive, retrospective, hospital-based study was conducted at Al-Mo'alem Medical City-Khartoum, Sudan from August to December 2018. Medical records of Type 2 diabetic patients, treated with HBOT plus standard wound care for DFUs, were included in the study. Data were analyzed by simple descriptive statistics and logistic regression. P ≤ 0.05 was considered statistically significant. The study results showed that 51.7% of patients had Wagner grade-3 ulcers and 28.3% had complete loss of protective sensation. Almost 61% of patients achieved complete ulcer healing while 16.7% underwent amputation. Twenty percent of patients treated with HBOT experienced ear barotraumas as adverse effects. Protective sensation (OR = 6.00, 95% CI = 1.79-20.16, p = 0.004) and more sessions of HBOT (OR = 17.35, 95% CI = 4.51-66.73, p = 0.000) were positive predictors of complete ulcer healing. Loss of protective sensation (OR = 0.17, 95% CI = 0.05-0.63, p = 0.007) was an indicator of amputation. Treatment with adjuvant HBOT enhanced ulcer healing and reduced amputation rate in patients with non-healing DFUs. HBOT could be considered a relatively safe intervention. |
| ArticleNumber | 102173 |
| Author | Mohamed, Elwasila M. Abdalla, Safa A. Suliman, Hayat Mohamed Osman, Wadah J.A. Fadol, Ethar Mohamedalfatih Abdoon, Iman Hassan Osman, Bashier |
| Author_xml | – sequence: 1 givenname: Ethar Mohamedalfatih surname: Fadol fullname: Fadol, Ethar Mohamedalfatih email: etharmohmed87@gmail.com organization: Master in Clinical Pharmacy, Clinical Pharmacy Program, Faculty of Pharmacy, University of Khartoum, Sudan – sequence: 2 givenname: Hayat Mohamed surname: Suliman fullname: Suliman, Hayat Mohamed email: hayatsuliman19@gmail.com organization: Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Sudan – sequence: 3 givenname: Bashier surname: Osman fullname: Osman, Bashier email: dbashier@gmail.com organization: Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Sudan – sequence: 4 givenname: Safa A. surname: Abdalla fullname: Abdalla, Safa A. email: safaarahim.sr@gmail.com organization: Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Sudan – sequence: 5 givenname: Wadah J.A. surname: Osman fullname: Osman, Wadah J.A. email: wadahj@yahoo.com organization: Department of Pharmacognosy, Faculty of Pharmacy, University of Khartoum, Sudan – sequence: 6 givenname: Elwasila M. surname: Mohamed fullname: Mohamed, Elwasila M. email: elgadidwas@yahoo.com organization: Department of Agricultural Extension and Rural Development, Faculty of Agriculture, University of Khartoum, Sudan – sequence: 7 givenname: Iman Hassan orcidid: 0000-0002-7453-5724 surname: Abdoon fullname: Abdoon, Iman Hassan email: imanabdoon@yahoo.com, imanabdoon@yahoo.com organization: Department of Pharmacology, Faculty of Pharmacy, University of Khartoum, Sudan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/34186354$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_life12071054 crossref_primary_10_1016_j_arr_2025_102779 crossref_primary_10_1155_2022_1372199 crossref_primary_10_1177_09287329241296417 crossref_primary_10_1016_j_diabres_2025_112318 crossref_primary_10_1016_j_scca_2025_100079 crossref_primary_10_3389_fbioe_2022_1039495 crossref_primary_10_52711_0974_360X_2025_00343 crossref_primary_10_1016_j_addr_2023_114727 |
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| Keywords | Hyperbaric oxygen therapy Therapeutic outcomes Ulcer healing Diabetic foot ulcers Amputation |
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| Title | Therapeutic outcomes evaluation of adjuvant hyperbaric oxygen therapy for non-healing diabetic foot ulcers among sudanese patients |
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