Soluble mimics of the cytoplasmic face of the human V1-vascular vasopressin receptor bind arrestin2 and calmodulin

Signal transduction by G protein-coupled receptors (GPCRs) is mediated by interactions between intracellular proteins and exposed motifs on the cytoplasmic face of these receptors. Arrestins bind to GPCRs and modulate receptor function either by interfering with heterotrimeric G protein signaling or...

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Vydané v:	Molecular pharmacology Ročník 70; číslo 1; s. 249
Hlavní autori:	Wu, Nan, Macion-Dazard, Rosemarie, Nithianantham, Stanley, Xu, Zhen, Hanson, Susan M, Vishnivetskiy, Sergey A, Gurevich, Vsevolod V, Thibonnier, Marc, Shoham, Menachem
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.07.2006
Predmet:	Amino Acid Sequence Arrestins - genetics Arrestins - metabolism Binding Sites Binding, Competitive Calmodulin - genetics Calmodulin - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cobalt - chemistry Cobalt - metabolism Humans Immunoblotting Kinetics Maltose-Binding Proteins Models, Molecular Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism Mutation - genetics Protein Binding Receptors, Vasopressin - chemistry Receptors, Vasopressin - genetics Receptors, Vasopressin - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Solubility Spectrometry, Fluorescence
ISSN:	0026-895X
On-line prístup:	Zistit podrobnosti o prístupe
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