Soluble mimics of the cytoplasmic face of the human V1-vascular vasopressin receptor bind arrestin2 and calmodulin

Signal transduction by G protein-coupled receptors (GPCRs) is mediated by interactions between intracellular proteins and exposed motifs on the cytoplasmic face of these receptors. Arrestins bind to GPCRs and modulate receptor function either by interfering with heterotrimeric G protein signaling or...

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Veröffentlicht in:	Molecular pharmacology Jg. 70; H. 1; S. 249
Hauptverfasser:	Wu, Nan, Macion-Dazard, Rosemarie, Nithianantham, Stanley, Xu, Zhen, Hanson, Susan M, Vishnivetskiy, Sergey A, Gurevich, Vsevolod V, Thibonnier, Marc, Shoham, Menachem
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.07.2006
Schlagworte:	Amino Acid Sequence Arrestins - genetics Arrestins - metabolism Binding Sites Binding, Competitive Calmodulin - genetics Calmodulin - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Cobalt - chemistry Cobalt - metabolism Humans Immunoblotting Kinetics Maltose-Binding Proteins Models, Molecular Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism Mutation - genetics Protein Binding Receptors, Vasopressin - chemistry Receptors, Vasopressin - genetics Receptors, Vasopressin - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Solubility Spectrometry, Fluorescence
ISSN:	0026-895X
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