Selective Regulatory Effects of Lactobacillus Plantarum Fermented Milk: Enhancing the Growth of Staphylococcus Epidermidis and Inhibiting Staphylococcus aureus and Escherichia coli

To address the limitation of traditional broad-spectrum antimicrobial agents in compromising skin microbiota homeostasis, this study developed Lactobacillus plantarum fermented milk (FM) as an innovative strategy for selectively regulating microbial communities to restore skin microbiota balance. FM...

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Vydáno v:Cosmetics (Basel) Ročník 12; číslo 5; s. 232
Hlavní autoři: Sun, Yajuan, Wang, Ying, Ren, Zixia, Wang, Shasha, Ding, Yun, Liu, Nan, Yang, Cheng, Zhao, Bingtian
Médium: Journal Article
Jazyk:angličtina
Vydáno: Basel MDPI AG 01.10.2025
Témata:
Amino acids
Analysis
Antimicrobial activity
Antimicrobial agents
Bacteria
Biotechnology
Citric acid
Competitiveness
Dermatologic agents
Dermatology
E coli
Escherichia coli
Fatty acids
Fermentation
Fermented milk products
Formulae, receipts, prescriptions
Growth
Homeostasis
Metabolism
Metabolites
Metabolomics
Methylene blue
microbiology
Microbiota
Microbiota (Symbiotic organisms)
Milk
Pathogens
Pyruvic acid
Skin
skin barrier
Staphylococcus aureus
Staphylococcus aureus infections
Staphylococcus epidermidis
New Brunswick
United States
Massachusetts
China
Beijing China
United States > US
Shanghai China
ISSN:2079-9284, 2079-9284
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Abstract To address the limitation of traditional broad-spectrum antimicrobial agents in compromising skin microbiota homeostasis, this study developed Lactobacillus plantarum fermented milk (FM) as an innovative strategy for selectively regulating microbial communities to restore skin microbiota balance. FM was produced through protease hydrolysis in combination with L. plantarum fermentation. Selective antibacterial properties were evaluated via monoculture experiments (Escherichia coli, Staphylococcus aureus, and Staphylococcus epidermidis) and pathogen–commensal co-culture systems. It was found that FM can selectively inhibit pathogens (E. coli and S. aureus) and promote the growth of commensal bacteria (S. epidermidis) in monoculture, and can reduce the growth and competitiveness of E. coli and S. aureus while relatively increasing the colony count of S. epidermidis in the co-culture system. Metabolomic profiling was further performed to identify metabolic alterations induced by FM. It was found that FM can activate the pyruvate metabolic node, significantly enhancing the metabolic fluxes of lactic acid, citric acid, and short-chain fatty acids, which triggered the acid stress response of pathogenic bacteria while consuming a considerable amount of energy, attenuating their reproductive capacity without impacting the growth of commensal bacteria. Overall, FM showed selective antimicrobial activity against pathogens (E. coli, and S. aureus) and preservation of commensal S. epidermidis, offering a foundational reference for the development of postbiotics aimed at maintaining cutaneous microbial homeostasis.
AbstractList To address the limitation of traditional broad-spectrum antimicrobial agents in compromising skin microbiota homeostasis, this study developed Lactobacillus plantarum fermented milk (FM) as an innovative strategy for selectively regulating microbial communities to restore skin microbiota balance. FM was produced through protease hydrolysis in combination with L. plantarum fermentation. Selective antibacterial properties were evaluated via monoculture experiments (Escherichia coli, Staphylococcus aureus, and Staphylococcus epidermidis) and pathogen–commensal co-culture systems. It was found that FM can selectively inhibit pathogens (E. coli and S. aureus) and promote the growth of commensal bacteria (S. epidermidis) in monoculture, and can reduce the growth and competitiveness of E. coli and S. aureus while relatively increasing the colony count of S. epidermidis in the co-culture system. Metabolomic profiling was further performed to identify metabolic alterations induced by FM. It was found that FM can activate the pyruvate metabolic node, significantly enhancing the metabolic fluxes of lactic acid, citric acid, and short-chain fatty acids, which triggered the acid stress response of pathogenic bacteria while consuming a considerable amount of energy, attenuating their reproductive capacity without impacting the growth of commensal bacteria. Overall, FM showed selective antimicrobial activity against pathogens (E. coli, and S. aureus) and preservation of commensal S. epidermidis, offering a foundational reference for the development of postbiotics aimed at maintaining cutaneous microbial homeostasis.
Audience Academic
Author Yang, Cheng
Sun, Yajuan
Wang, Shasha
Ding, Yun
Liu, Nan
Wang, Ying
Ren, Zixia
Zhao, Bingtian
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SubjectTerms Amino acids
Analysis
Antimicrobial activity
Antimicrobial agents
Bacteria
Biotechnology
Citric acid
Competitiveness
Dermatologic agents
Dermatology
E coli
Escherichia coli
Fatty acids
Fermentation
Fermented milk products
Formulae, receipts, prescriptions
Growth
Homeostasis
Metabolism
Metabolites
Metabolomics
Methylene blue
microbiology
Microbiota
Microbiota (Symbiotic organisms)
Milk
Pathogens
Pyruvic acid
Skin
skin barrier
Staphylococcus aureus
Staphylococcus aureus infections
Staphylococcus epidermidis
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Title Selective Regulatory Effects of Lactobacillus Plantarum Fermented Milk: Enhancing the Growth of Staphylococcus Epidermidis and Inhibiting Staphylococcus aureus and Escherichia coli
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https://doaj.org/article/1a84a2d4be264f09a8f559cfc7eac606
Volume 12
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