Tetracycline-like resistome of ancient human guts

Tetracyclines were discovered over 70 years ago and their use resulted in the emergence of tetracycline-resistance microorganisms; however, it has been hypothesized that tetracycline-resistance may have originated in the environment, and that determinants were transferred to the human gut microbiota...

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Bibliographic Details
Published in:Human microbiome journal Vol. 10; pp. 21 - 26
Main Authors: Santiago-Rodriguez, Tasha M., Fornaciari, Gino, Luciani, Stefania, Toranzos, Gary A., Marota, Isolina, Giuffra, Valentina, Sangwan, Naseer, Cano, Raul J.
Format: Journal Article
Language:English
Published: Elsevier Ltd 01.12.2018
Subjects:
Ancient microbiome
antibiotic resistance genes
evolution
Gut microbiome
high-throughput nucleotide sequencing
humans
Infectious Disease
intestinal microorganisms
microbiome
Mummies
Resistome
Tetracycline-resistance
tetracyclines
Resistome
Tetracycline-resistance
Gut microbiome
Mummies
Ancient microbiome
ISSN:2452-2317, 2452-2317
Online Access:Get full text
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Summary:Tetracyclines were discovered over 70 years ago and their use resulted in the emergence of tetracycline-resistance microorganisms; however, it has been hypothesized that tetracycline-resistance may have originated in the environment, and that determinants were transferred to the human gut microbiota. Ancient microbiomes represent an opportunity to explore the transmission of tetracycline-resistance determinants from the environment to humans. In the present study, tetracycline-like resistomes of three pre-Inca/Inca (10–15th centuries), and five Italian nobility (15–16th centuries) mummies were characterized using high-throughput sequencing. Sequences exhibited low homology to present-day determinants. Results may aid in the understanding of the evolution of tetracycline-resistance.
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ISSN:2452-2317
2452-2317
DOI:10.1016/j.humic.2018.07.001