Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias

Mutations in RNA splicing factors are prevalent across cancers and generate recurrently mis-spliced mRNA isoforms. Here, we identified a series of bona fide neoantigens translated from highly stereotyped splicing alterations promoted by neomorphic, leukemia-associated somatic splicing machinery muta...

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Bibliographic Details
Published in:	Cell Vol. 188; no. 13; p. 3422
Main Authors:	Kim, Won Jun, Crosse, Edie I, De Neef, Emma, Etxeberria, Inaki, Sabio, Erich Y, Wang, Eric, Bewersdorf, Jan Philipp, Lin, Kuan-Ting, Lu, Sydney X, Belleville, Andrea, Fox, Nina, Castro, Cynthia, Zhang, Pu, Fujino, Takeshi, Lewis, Jennifer, Rahman, Jahan, Zhang, Beatrice, Winick, Jacob H, Lewis, Alexander M, Stanley, Robert F, DeWolf, Susan, Urben, Brigita Meškauskaitė, Takizawa, Meril, Krause, Tobias, Molina, Henrik, Chaligne, Ronan, Koppikar, Priya, Molldrem, Jeffrey, Gigoux, Mathieu, Merghoub, Taha, Daniyan, Anthony, Chandran, Smita S, Greenbaum, Benjamin D, Klebanoff, Christopher A, Bradley, Robert K, Abdel-Wahab, Omar
Format:	Journal Article
Language:	English
Published:	United States 26.06.2025
Subjects:	Antigens, Neoplasm - genetics Antigens, Neoplasm - immunology CD8-Positive T-Lymphocytes - immunology Humans Leukemia - genetics Leukemia - immunology Mutation Receptors, Antigen, T-Cell - genetics Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism RNA Splicing - genetics RNA Splicing Factors - genetics Serine-Arginine Splicing Factors - genetics neoantigen ZRSR2 T cell receptor acute myeloid leukemia immunotherapy myelodysplastic syndromes SRSF2 U2AF1 SF3B1 RNA splicing
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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