Nicotinamide abrogates acute lung injury caused by ischaemia/reperfusion

Poly (ADP-ribose) synthase or polymerase (PARS and PARP, respectively) is a cytotoxic enzyme which causes cellular damage. Nicotinamide, a compound of vitamin B complex, has been reported to exert an inhibitory effect on PARS or PARP. The present study tests the effects of nicotinamide on acute lung...

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Bibliographic Details
Published in:	The European respiratory journal Vol. 30; no. 2; p. 199
Main Authors:	Su, C-F, Liu, D D, Kao, S J, Chen, H I
Format:	Journal Article
Language:	English
Published:	England 01.08.2007
Subjects:	Adenosine Triphosphate - metabolism Analysis of Variance Animals Disease Models, Animal Free Radicals Interleukin-1 - metabolism Ischemia - pathology Lung - blood supply Lung - metabolism Lung - pathology Lung Injury Male Methylguanidine - metabolism Niacinamide - pharmacology Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Poly(ADP-ribose) Polymerases - metabolism Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Reperfusion Injury - pathology Tumor Necrosis Factor-alpha - metabolism
ISSN:	0903-1936
Online Access:	Get more information
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