Nicotinamide abrogates acute lung injury caused by ischaemia/reperfusion

Poly (ADP-ribose) synthase or polymerase (PARS and PARP, respectively) is a cytotoxic enzyme which causes cellular damage. Nicotinamide, a compound of vitamin B complex, has been reported to exert an inhibitory effect on PARS or PARP. The present study tests the effects of nicotinamide on acute lung...

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Vydané v:	The European respiratory journal Ročník 30; číslo 2; s. 199
Hlavní autori:	Su, C-F, Liu, D D, Kao, S J, Chen, H I
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England 01.08.2007
Predmet:	Adenosine Triphosphate - metabolism Analysis of Variance Animals Disease Models, Animal Free Radicals Interleukin-1 - metabolism Ischemia - pathology Lung - blood supply Lung - metabolism Lung - pathology Lung Injury Male Methylguanidine - metabolism Niacinamide - pharmacology Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Poly(ADP-ribose) Polymerases - metabolism Rats Rats, Sprague-Dawley Reperfusion Injury - drug therapy Reperfusion Injury - pathology Tumor Necrosis Factor-alpha - metabolism
ISSN:	0903-1936
On-line prístup:	Zistit podrobnosti o prístupe
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