Multi-scale simulation of L-selectin–PSGL-1-dependent homotypic leukocyte binding and rupture

L-selectin–PSGL-1-mediated polymorphonuclear (PMN) leukocyte homotypic interactions potentiate the extent of PMN recruitment to endothelial sites of inflammation. Cell–cell adhesion is a complex phenomenon involving the interplay of bond kinetics and hydrodynamics. As a first step, a 3-D computation...

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Bibliographic Details
Published in:	Biomechanics and modeling in mechanobiology Vol. 9; no. 5; pp. 613 - 627
Main Authors:	Gupta, V. K., Sraj, Ihab A., Konstantopoulos, Konstantinos, Eggleton, Charles D.
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer-Verlag 01.10.2010 Springer Nature B.V
Subjects:	Adhesion Biological and Medical Physics Biomechanics Biomedical Engineering and Bioengineering Biophysics Cell adhesion & migration Computer Simulation Engineering Fluid dynamics Hydrodynamics Kinetics L-Selectin - metabolism Leukocytes Leukocytes - metabolism Ligands Load distribution Membrane Glycoproteins - metabolism Monte Carlo simulation Original Paper Protein Binding Receptors, Cell Surface - metabolism Theoretical and Applied Mechanics Receptor–ligand bond kinetics Immersed boundary method Cell deformation Monte Carlo simulation Cell adhesion
ISSN:	1617-7959, 1617-7940, 1617-7940
Online Access:	Get full text
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