Activation-induced Cell Death Drives Profound Lung CD4 + T-Cell Depletion in HIV-associated Chronic Obstructive Pulmonary Disease

As overall survival improves, individuals with HIV infection become susceptible to other chronic diseases, including accelerated chronic obstructive pulmonary disease (COPD). To determine whether individuals with HIV-associated COPD exhibit dysregulated lung mucosal T-cell immunity compared with con...

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Bibliographic Details
Published in:	American journal of respiratory and critical care medicine Vol. 190; no. 7; pp. 744 - 755
Main Authors:	Popescu, Iulia, Drummond, M. Bradley, Gama, Lucio, Coon, Tiffany, Merlo, Christian A., Wise, Robert A., Clements, Janice E., Kirk, Gregory D., McDyer, John F.
Format:	Journal Article
Language:	English
Published:	United States American Thoracic Society 01.10.2014
Subjects:	Apoptosis - immunology Bronchoalveolar Lavage Fluid - immunology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Cell Death Cohort Studies fas Receptor - immunology Female Flow Cytometry - methods HIV Infections - complications HIV Infections - immunology Humans Immunity, Mucosal - immunology Leukocytes, Mononuclear - immunology Longitudinal Studies Lung - immunology Male Middle Aged Original Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - immunology Viral Load - immunology apoptosis HIV T cells immune activation COPD
ISSN:	1073-449X, 1535-4970, 1535-4970
Online Access:	Get full text
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